US3839153A - Process for the detection and determination of specific binding proteins and their corresponding bindable substances - Google Patents

Process for the detection and determination of specific binding proteins and their corresponding bindable substances Download PDF

Info

Publication number
US3839153A
US3839153A US00206952A US20695271A US3839153A US 3839153 A US3839153 A US 3839153A US 00206952 A US00206952 A US 00206952A US 20695271 A US20695271 A US 20695271A US 3839153 A US3839153 A US 3839153A
Authority
US
United States
Prior art keywords
antibody
determination
enzyme
conjugate
determined
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
US00206952A
Inventor
A Schuurs
Weemen B Van
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Akzona Inc
Original Assignee
Akzona Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Akzona Inc filed Critical Akzona Inc
Application granted granted Critical
Publication of US3839153A publication Critical patent/US3839153A/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
    • G01N33/743Steroid hormones
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/536Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
    • G01N33/537Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with separation of immune complex from unbound antigen or antibody
    • G01N33/539Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with separation of immune complex from unbound antigen or antibody involving precipitating reagent, e.g. ammonium sulfate
    • G01N33/541Double or second antibody, i.e. precipitating antibody
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00Chemistry: molecular biology and microbiology
    • Y10S435/964Chemistry: molecular biology and microbiology including enzyme-ligand conjugate production, e.g. reducing rate of nonproductive linkage
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00Chemistry: molecular biology and microbiology
    • Y10S435/971Capture of complex after antigen-antibody reaction
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00Chemistry: molecular biology and microbiology
    • Y10S435/975Kit
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00Chemistry: analytical and immunological testing
    • Y10S436/807Apparatus included in process claim, e.g. physical support structures
    • Y10S436/808Automated or kit
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00Chemistry: analytical and immunological testing
    • Y10S436/815Test for named compound or class of compounds
    • Y10S436/817Steroids or hormones
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00Chemistry: analytical and immunological testing
    • Y10S436/815Test for named compound or class of compounds
    • Y10S436/817Steroids or hormones
    • Y10S436/818Human chorionic gonadotropin

Definitions

  • ABSTRACT The invention relates to a process for the detection [30] Foreign Application Priority Data and determination of a component of the reaction be- Dec. 18, 1970 Netherlands 7018838 tween 3 Specific binding Protein and the correspond" ing bindable substance contacting a fluid containing 52 US. Cl. 195/1035 R, 424/12, 195/63 one of these Components with a conjugate Of the bind- 51 Int. Cl. G01n 31/14 able Substance with an enzyme and of antibodies [58] Field 01 Search 195/1035 R; 424/12; against the Specific binding protein which latter 23/230 B ponent is brought in an insoluble form, if necessary, in
  • antibodies as specific binding proteins, and the corresponding antigens as bindable substances.
  • Substances which can be determined with this system are, inter alia, protein hormones and their antibodies, or virus antigens and their antibodies;
  • haptens as bindable substance.
  • the haptens are defined as protein-free substances, which can react with antibodies, without being able to induce them.
  • Substances which can be determined in such a system are, inter alia, steroid hormones and vitamines;
  • proteins which in the body act as receptor or transport molecules as specific binding proteins, and substances which are bound by them as bindable substances.
  • This system is e.g., suitable for the determination of steroid hormones, but also of thyroxine and triiodothyronine, vitamine 8, intrinsic factor, and adrenocorticotropic hormone.
  • the separation methods can be divided as follows:
  • conjugate and enzyme conjugate are used as synonyms for the coupling product of the bindable substance and the enzyme.
  • the bindable substance can be detected and determined by bringing together the unknown sample or a dilution series of same with a known amount of a conjugate of the substance to be determined and an enzyme, and with an amount of specific binding protein, depending on the amount of enzyme conjugate that was added. Then an amount, preferably an excess, of the insoluble-made antibodies against the specific binding protein is added, so that all the enzyme conjugate that has reacted with the binding protein is coupled via this protein to these insoluble antibodies. 1n proportion as there is more bindable substance present in the sample, less enzyme conjugate will react with the specific binding protein and ultimately get into the insoluble phase; the result is that more unbound enzyme conjugate remains in the liquid phase, which can simply be determined there.
  • the specific binding protein can be determined by incubating the sample or a dilution series of same with a known amount of enzyme conjugate and with an amount of the insoluble-made antibodies against the specific binding protein.
  • the enzyme activity can only pass into the insoluble phase if the conjugate has reacted with the specific binding protein: the more specific binding protein there is in the sample, the less of bound enzyme conjugate remains in the liquid phase.
  • the sensitivity of the test systems described can be varied by altering the quantities of the reagents (whether or not in the same ratio).
  • the amount of enzyme conjugate that can be applied is limited at the lower end by the requirement that its enzyme activity can be measured reasonably, so that the sensitivity of the test systems has a limit.
  • the minimum measurable enzyme activity depends inter alia on the nature of the enzyme used for the coupling and on the nature of the substrate and of the incubation period of the enzyme reaction.
  • affinity of the specific binding proteins strongly influences the sensitivity of the determination. For a highly sensitive test system specific binding proteins with a higher affinity are required.
  • the quantity of enzyme conjugate will be determined with the help of the enzyme activity; then this quantity is incubated with a dilution series of the specific binding protein to determine the required quantity of this protein.
  • a quantity of specific binding protein is chosen, which binds 50-90% of the enzyme conjugate.
  • the insoluble-made antibodies against the specific binding protein are preferably added in excess in the two types of determination; the dosing of same is determined in preliminary tests.
  • radioisotopes can be replaced by working with enzymes. This requires considerably less laboratory facilities and apparatus, whilst the staff can be less highly qualified. Moreover, working with radioactive isotopes is highly limited because of legal regulations. Further the reagents according to the invention will keep long and the safety is increased;
  • the combination ofDouble Antibody and Solid Phase methods offers several advantages over the existing methods.
  • the performing of the found method viz.: addition of insoluble-made antibodies against the specific binding protein, incubation, centrifuging and measuring, is very simple.
  • the closing is often easier than in the solid phase methods because it suffices to add an excess of insoluble material, whereas in the solid phase methods an accurately measured amount of material has to be used.
  • the affinity of the binding protein for the bindable substance is not impaired by the binding to the carrier material, which can be the case in the solid phase method.
  • a further advantage over the latter method is the rapid equilibrium adjustment of the reaction between specific binding protein and bindable substance (both in solution).
  • a further advantage is that in the DASP method the insoluble-made antibody, called immunoadsorbent below, can be used in any system in which antibodies are used as specific binding protein, provided that these antibodies have been prepared in the same animal species.
  • the antibodies have to be made insoluble.
  • the double antibody method is very sensitive for relatively low variations in salt concentrations, pH and the like, which makes a rigid control of the conditions necessary.
  • the method requires the addition of carrier y-globuline and consequently much second antibody to obtain an immune precipitate. In addition to being a simpler procedure.
  • the DASP method which does not require "carrier” y-globuline, thus leads to material saving. Further it be added that a double antibody-like separation applied to transport or receptor proteins is not possible. as no suitable carrier protein is available for this purpose.
  • the method according to the invention will therefore offer a unique opportunity in this respect.
  • the method according to the present invention can easily be automatized. In principle it is possible to bring the reaction components together at once or to add them in any sequence. It was found, however, that the determination acquires a higher sensitivity if the immunoadsorbent is added after the incubation of the other components.
  • the reagent required for the invention viz. the coupling product of antigen, hapten or bindable substance with an enzyme
  • These methods can also be used to bind a hapten or a low-molecular bindable substance to an enzyme, provided that one substance possesses one or more aminogroups and the other one or more carboxyl-groups. If the latter is not the case then it is possible to introduce the desired group into the molecule to be coupled with the help of known organo-chemical processes.
  • Methods are also known to bind amino or earboxyl-groups together, whether or not by introducing a bridge.
  • the choice of the enzyme which is taken up in the coupling product is determined by a number of properties of that enzyme. It is, of course, essential that the enzyme should be resistant to the coupling with another molecule, i.e., modification of one or more aminoacid side chains. Also of great importance is the specific activity of the enzyme. As less enzyme conjugate needs to be added to reach a measurable enzyme effect, the test system grows more sensitive. Further those enzymes are to be preferred, of which the determination of the activity can be made in a simple manner. In the first place those enzymes are considered that can be determined colorimetrically, spectrophotometrically or fluorimetrically. This kind of determinations is suitable for automation, which is an additional advantage.
  • catalase peroxidase
  • ,B-glucoronidase ,B-D-glucosidase
  • B-D- galactosidase urease
  • glucose oxidase galactose oxidase
  • alkaline phosphatase alkaline phosphatase
  • the enzyme activity of the liquid or solid phase of the reaction mixture or of the two phases can be determined. Most simple is, however, to determine the enzyme activity of the liquid phase.
  • the insoluble-made antibodies against the specific binding proteins which are also an essential reagent for the process of the invention, can also be prepared in a known way.
  • the antibodies can be prepared by taking a purified preparation of the specific binding protein,
  • the serum of the treated animal, or the gammaglobuline fraction thereof can be made insoluble by cross-linking with compounds such as glutaric aldehyde and chloroformic acid ethyl ester, or by binding to solid carrier particles, either physically by adsorption, or chemically by the formation of covalent bonds.
  • solid carriers can be considered materials such as cellulose (modified or not), agarose, cross-linked dcxtran, polystyrene and the like.
  • Covalent binding of the antibodies to these materials can be effected with the help of substances such as carbodiimides, diand tri-chloro-striazines, glutaric aldehyde, cyanogenbromide, and e.g., by diazotation.
  • substances such as carbodiimides, diand tri-chloro-striazines, glutaric aldehyde, cyanogenbromide, and e.g., by diazotation.
  • the forms in which the reagents can be used are manifold.
  • the enzyme-conjugated component of the reaction system can be freeze-dried, or dissolved in a buffer.
  • a solid carrier can be used, e.g., a strip of paper impregnated with the conjugate. This applies equally to the required specific binding proteins.
  • the insoluble component can be brought in the form of particles of different dimensions, such as granules, flakes, rods, or in the form of a strip of some carrier material.
  • test pack is applied by preference. This consists mainly of:
  • test pack can further contain the reagents required for the enzyme determinations, and also auxiliary means for conducting the test, such as test tubes, pipettes and bottles with dilution liquid.
  • auxiliary means for conducting the test such as test tubes, pipettes and bottles with dilution liquid.
  • test pack An important embodiment of a test pack according to the present invention is a test pack to be used for the determination of gonadotropic hormones, and particularly for the determination of HCG (Human Chorionic Gonadotropin) as a means to diagnose pregnancy already in a very early stage, which test pack consists of an ampoule, tube, bottle or other container containing as essential ingredients, in separate lyophilized layers, pre-determined amounts of:
  • HCG- peroxidase a conjugate of HCG with an enzyme, e.g., HCG- peroxidase.
  • a preferably applied method for the determination of the enzyme activity consists in contacting an indicatorpaper impregnated with enzyme reagents, e.g., in case use is made of a peroxidase, a H O -supplier like urea- H ,O and a colour-reagent like o-tolidine.
  • Example 1 Determination of human (HCG) a. Preparation of HCG-HRP. 5 mg HCG and 20 mg horse radish peroxidase (HRP) were dissolved in 2 ml 0.05 M phosphate buffer of pH 6.2. After addition of 40 ,ul 25% glutaric aldehyde solution the mixture was shaken for 2 hours at room temperature. After 5 minutes centrifugation at 250 g, the liquid was fractionated over Sephadex G-200 in 0.05 M phosphate buffer of pH 6.2. The fractions of which the highest percentage enzyme activity was bound by antibodies against HCG were used in the test system.
  • HCG-HRP horse radish peroxidase
  • the suspension was centrifuged, washed and the precipitate re-suspended in 43 ml 0.05 M sodium borate of pH 8.6. Then 7 ml of the prepared y-globuline solution was added. The mixture was stirred for 26 hours at 4C, then centrifuged and washed with 0.02 M phosphate buffer of pH 6.0.
  • HCG-HRP conjugate a dilution series (32-16-8-4-2-1-05-0 lU/ml) of HCG in 0.02 M phosphate buffer with pH 6.0 was prepared, which contained 2% v/v normal sheep serum.
  • 0.5 ml of each of the HCG-containing samples was incubated with 0.1 ml rabbit-(anti-HCG) serum and 0.1 ml HCG-HRP conjugate, both in suitable dilution, for half an hour at room temperature.
  • 0.3 ml of the immunoadsorbent 10 mg/ml) prepared acccording to d) was added, and the resulting mixture was rotated at room temperature for 1 hour.
  • Example 11 Determination of insuline and anti-insuline.
  • a Preparation of insuline-(glucose oxidase). 5 mg pig insuline and 25 mg glucose oxidase were dissolved in 2 ml 0.05 M phosphate buffer of pH 6.5. To this, 5 ,ul 25% glutaric aldehyde solution was added, after which the mixture was shaken for 90 minutes at room temperature. The mixture was fractionated over Sephadex G-200 in 0.05 M phosphate buffer of pH 6.5. The fractions of which the highest percentage of enzyme activity could be bound by antibodies against insuline, were used in the test system.
  • guinea pigs were given a weekly intramuscular injection with 1 mg pig insuline in complete Freunds adjuvans over a period from 4-8 weeks. After two weeks rest the animals were given 1 mg additional insuline by intravenous injection without adjuvans. 2 weeks after that the animals were bled. Hypoglycaemia occurring at times was counteracted by intraperitoneal administration of glucose.
  • Guinea pig y-globuline was prepared by adding 1 volume saturated ammonium sulphate solution to 2 volumes guinea pig serum. The precipitate formed was twice washed with 33% saturated ammonium sulphate solution, and then taken up in a physiological salt solution.
  • a sheep was immunized with increasing doses of the prepared 'y-globuline: 0.5, 1 and 2 mg. The injections were given every two weeks, whilst the immunogen was mixed with complete Freunds adjuvans. Two weeks after the last injection an additional 2 mg y-globuline in a physiological salt solution were given, and 1 week later the animal was bled.
  • ml insuline-(glucose oxidase), in a suitable dilution was incubated with 0.4 m1 of a dilution series of a guinea pig anti-insuline serum for 4 hours.
  • the dilution series was made with 0.05 M phosphate buffer of pH 6.0.
  • 0.3 ml immunoadsorbent (15 mg/ml) and 0.2 ml buffer were added and the mixture was rotated during the night at 4C. After centrifuging the enzyme activity of the supernatant was determined by incubating 0.5 ml of same with 2.5 ml substrate for 30 minutes, and then measuring the extinction at 460 nm.
  • the substrate con tained 50 mg glucose, 10 ug peroxidase and 1 mg S-aminosalicyclic acid per 2.5 ml 0.05 M phosphate buffer of pH 6.0.
  • the antibody content of the different serums could be intercompared.
  • the serum dilution at which 50% of the total combinable enzyme activity is bound.
  • sheep was injected once in four weeks with 4 mg oestradiol-l7-succinyl-BSA in complete Freunds adjuvans. At regular intervals blood was taken from the sheep. The serum was absorbed with BSA that was made insoluble.
  • Sheep-y-globuline was prepared as described in example I, but now with 16% w/v sodium sulphate. Rabbits were immunized with this sheepy-globuline according to the following schedule:
  • Example lV Determination of cortisol and corticoid-binding globuline.
  • CBG Corticoid-binding globuline
  • the y-globuline fraction of anti-CBG serum was coupled to m-aminobenzyloxymethylcellulose, as described in example lll.
  • CBG CBG oxidase
  • a suitable dilution series of transcortine ranging from 0-1280 ng/ml
  • 0.5 ml was incubated for 15 minutes with 0.2 ml cortisol-21- (galactose oxidase) in a suitable dilution.
  • 0.3 ml immunoadsorbent suspension (5 mg/ml) was added, and the mixture rotated for 15 minutes. The two incubations were conducted at 4C. Then the enzyme activity in the supernatant was measured as under d).
  • the sensitivity of the test system proved to be 50 ng/ml.
  • Example V In a bottle the following reagents were subsequently 65 lyophilized in separate layers:
  • step (b) separating the resulting mixture into a liquid phase and a solid phase by adding an insolubilized antibody against the antibody of step (b);
  • a test pack for the detection and determination of a bindable substance selected from the group consisting of an antigen and a hapten in a fluid sample comprising:
  • a a known amount of a conjugate of said bindable substance with an enzyme
  • b a corresponding known amount of an antibody against said antigen or hapten
  • c a known amount of an insolubilized antibody 15 against said antibody
  • d a stabilizer
  • e a substrate for the determination of the enzyme activity and thus of the quantity of the antigen or hapten to be determined.
  • a test pack for the detection and determination of an antibody in a fluid sample, utilizing the reaction between said antibody and an antigen or hapten to said antibody, comprising:
  • a stabilizer for the determination of the enzyme activity and thus of the quantity of antibody to be determined.
  • a a predetermined amount of a conjugate of human chorionic gonadotropin and an enzyme

Abstract

The invention relates to a process for the detection and determination of a component of the reaction between a specific binding protein and the corresponding bindable substance contacting a fluid containing one of these components with a conjugate of the bindable substance with an enzyme and of antibodies against the specific binding protein which latter component is brought in an insoluble form, if necessary, in combination with the specific binding protein, and determining the activity of the liquid or solid phase of the resulting reaction mixture.

Description

United States Patent 1 1 1111 3,839,153 Schuurs et al. p Oct. 1, 1974 [5 PROCESS FOR THE DETECTION AND 3,654,090 4 1972 Schuurs et al 195 1035 R DETERMINATION OF SPECIFIC BINDING OTHER PUBLICATIONS PROTEINS AND THEIR CORRESPONDING Nd l I t l K k S R h BINDABLE SUBSTANCES Ml gey e a. aroins a ymposia on esearc ethods 1n Reproductive Endocrinology, lst Sympo- [75] Inventors: Antonius I-Iermanus Wilhelmus sium, Sept. 23-25, I969 in Acta Endocrinologica, Maria SchuurS; Bflllke KlaaS Van Supplementum (Copenhagen), 142: 247-256 (1969). Weemen, both of NetherlandS Miles et al. Nature 219; 186-189 (1968).
[73] Assignee: Akzona Incorporated, Asheville,
N C Primary ExaminerAlvin E. Tanenholtz w Filed: Dec. 10,1971 Attorney, Agent, or Fzrm Hugo E eisberger [21] Appl. No.: 206,952 [57] ABSTRACT The invention relates to a process for the detection [30] Foreign Application Priority Data and determination of a component of the reaction be- Dec. 18, 1970 Netherlands 7018838 tween 3 Specific binding Protein and the correspond" ing bindable substance contacting a fluid containing 52 US. Cl. 195/1035 R, 424/12, 195/63 one of these Components with a conjugate Of the bind- 51 Int. Cl. G01n 31/14 able Substance with an enzyme and of antibodies [58] Field 01 Search 195/1035 R; 424/12; against the Specific binding protein which latter 23/230 B ponent is brought in an insoluble form, if necessary, in
combination with the specific binding protein, and de- 5 References Cited termining the activity of the liquid or solid phase of UNITED STATES PATENTS the resulting reaction mixture.
6 Claims, No Drawings PROCESS FOR THE DETECTION AND DETERMINATION OF SPECIFIC BINDING PROTEINS AND THEIR CORRESPONDING BINDABLE SUBSTANCES It is known that a component of the reaction between a specific binding protein and the corresponding bindable substance can be detected and determined by incubating one of the named components, labelled by a marker, in a reaction mixture which at least contains the other component, and then effecting a separation between the marked component that is and that is not bound to its binding partner, and finally determining the marker in at least one of the two fractions obtained. The distribution of the marked component over the two fractions is a measure of the amount of substance to be determined and present in the sample. Three systems can be described, in which the above method is applied.
a. antibodies as specific binding proteins, and the corresponding antigens as bindable substances. Substances which can be determined with this system are, inter alia, protein hormones and their antibodies, or virus antigens and their antibodies;
b. antibodies as specific binding proteins, and haptens as bindable substance. Here the haptens are defined as protein-free substances, which can react with antibodies, without being able to induce them. Substances which can be determined in such a system are, inter alia, steroid hormones and vitamines;
c. proteins which in the body act as receptor or transport molecules as specific binding proteins, and substances which are bound by them as bindable substances. This system is e.g., suitable for the determination of steroid hormones, but also of thyroxine and triiodothyronine, vitamine 8, intrinsic factor, and adrenocorticotropic hormone.
The most important points in the methods of determination described are the application of a marker and the separation of the marked component into a fraction which is, and a fraction which is not bound to the corresponding component.
In the methods practically used up to now only radioactive atoms have been applied as marker, e.g., 131,, 125,, l4 3 57 This method usually stands out by a high sensitivity. However, the application of this method is limited to institutes which have the required specialized apparatus available.
The separation methods can be divided as follows:
a. methods depending on the difference in physical properties between the non-bound, marked component and its complex with the binding partner, such as gelfiltration, electrophoresis, salt precipitation, and adsorption to dextran-coated charcoal;
b. the so-called solid phase methods, in which beforehand one component has already been brought into an insoluble form by cross-linking or by covalent binding or physical adsorption to a solid carrier.
c. the so-called double antibody method in which the complex formed, antigen (or hapten)-antibody, is precipitated with the help of antibodies against the antibody in the complex, which method is only known for systems in which antibodies are involved. Whilst the methods mentioned under (a) and (c) are relatively complicated to perform, those mentioned under (b) suffer from the disadvantage that as a result of bringing a reaction component in an insoluble form, its affinity for the reaction partner usually decreases. A high affinity is, however, essential for realizing a sensitive system of test.
Now a process was found for the detection and determination of a component of the reaction between a specific binding protein and the corresponding bindable substance, applying the known binding affinity of such components for one another, characterized in that use is made of a given amount of a coupling product of the combinable substance with an enzyme, and of antibodies against the specific combining protein, brought in an insoluble form, and that after the reaction the enzyme activity is determined in the liquid or solid phase of the reaction mixture, which activity is a measure of the amount of the component to be determined.
A frequent and advantageous use of this method is made when antibodies are made to act as specific binding protein and antigen or hapten as corresponding bindable substance.
In the present description the term conjugate and enzyme conjugate are used as synonyms for the coupling product of the bindable substance and the enzyme.
The bindable substance can be detected and determined by bringing together the unknown sample or a dilution series of same with a known amount of a conjugate of the substance to be determined and an enzyme, and with an amount of specific binding protein, depending on the amount of enzyme conjugate that was added. Then an amount, preferably an excess, of the insoluble-made antibodies against the specific binding protein is added, so that all the enzyme conjugate that has reacted with the binding protein is coupled via this protein to these insoluble antibodies. 1n proportion as there is more bindable substance present in the sample, less enzyme conjugate will react with the specific binding protein and ultimately get into the insoluble phase; the result is that more unbound enzyme conjugate remains in the liquid phase, which can simply be determined there.
The specific binding protein can be determined by incubating the sample or a dilution series of same with a known amount of enzyme conjugate and with an amount of the insoluble-made antibodies against the specific binding protein. The enzyme activity can only pass into the insoluble phase if the conjugate has reacted with the specific binding protein: the more specific binding protein there is in the sample, the less of bound enzyme conjugate remains in the liquid phase.
The sensitivity of the test systems described can be varied by altering the quantities of the reagents (whether or not in the same ratio). However, the amount of enzyme conjugate that can be applied is limited at the lower end by the requirement that its enzyme activity can be measured reasonably, so that the sensitivity of the test systems has a limit. The minimum measurable enzyme activity depends inter alia on the nature of the enzyme used for the coupling and on the nature of the substrate and of the incubation period of the enzyme reaction. Further the affinity of the specific binding proteins strongly influences the sensitivity of the determination. For a highly sensitive test system specific binding proteins with a higher affinity are required.
The quanitities of reagent required per determination are established empirically.
For the determination of the bindable substance the quantity of enzyme conjugate will be determined with the help of the enzyme activity; then this quantity is incubated with a dilution series of the specific binding protein to determine the required quantity of this protein. By preference a quantity of specific binding protein is chosen, which binds 50-90% of the enzyme conjugate. Finally it is checked whether the desired sensitivity has indeed been reached, by testing a dilution series of the substance under test in the system. For the determination of the specific binding protein another consideration regarding the dosage of the enzyme conjugate is its activity, which should be reasonably determinable.
The insoluble-made antibodies against the specific binding protein are preferably added in excess in the two types of determination; the dosing of same is determined in preliminary tests. The advantages of this method over the existing are:
a. working with radioisotopes can be replaced by working with enzymes. This requires considerably less laboratory facilities and apparatus, whilst the staff can be less highly qualified. Moreover, working with radioactive isotopes is highly limited because of legal regulations. Further the reagents according to the invention will keep long and the safety is increased;
b. the combination ofDouble Antibody and Solid Phase methods, for ease of reference called DASP method below, offers several advantages over the existing methods. Thus the performing of the found method, viz.: addition of insoluble-made antibodies against the specific binding protein, incubation, centrifuging and measuring, is very simple. The closing is often easier than in the solid phase methods because it suffices to add an excess of insoluble material, whereas in the solid phase methods an accurately measured amount of material has to be used. Moreover, the affinity of the binding protein for the bindable substance is not impaired by the binding to the carrier material, which can be the case in the solid phase method. A further advantage over the latter method is the rapid equilibrium adjustment of the reaction between specific binding protein and bindable substance (both in solution). A further advantage is that in the DASP method the insoluble-made antibody, called immunoadsorbent below, can be used in any system in which antibodies are used as specific binding protein, provided that these antibodies have been prepared in the same animal species. On the other hand, for each antigen or hapten to be determined with the solid phase method, the antibodies have to be made insoluble. The double antibody method is very sensitive for relatively low variations in salt concentrations, pH and the like, which makes a rigid control of the conditions necessary. Moreover, the method requires the addition of carrier y-globuline and consequently much second antibody to obtain an immune precipitate. In addition to being a simpler procedure. the DASP method, which does not require "carrier" y-globuline, thus leads to material saving. Further it be added that a double antibody-like separation applied to transport or receptor proteins is not possible. as no suitable carrier protein is available for this purpose. The method according to the invention will therefore offer a unique opportunity in this respect.
c. The method according to the present invention can easily be automatized. In principle it is possible to bring the reaction components together at once or to add them in any sequence. It was found, however, that the determination acquires a higher sensitivity if the immunoadsorbent is added after the incubation of the other components.
The reagent required for the invention, viz. the coupling product of antigen, hapten or bindable substance with an enzyme, can be prepared in a known manner. These methods can also be used to bind a hapten or a low-molecular bindable substance to an enzyme, provided that one substance possesses one or more aminogroups and the other one or more carboxyl-groups. If the latter is not the case then it is possible to introduce the desired group into the molecule to be coupled with the help of known organo-chemical processes. Methods are also known to bind amino or earboxyl-groups together, whether or not by introducing a bridge. Finally compounds as glutaric aldehyde, difluorodini trodiphenyl-sulphon and diand tri-chloro-s-triazine can often be used for the coupling in question. It can be necessary to separate the prepared enzyme conjugates from non-converted substances or from substances that have become inactive. To this end the known biochemical methods can be used, such as precipitation with organic solvents, gelfiltration, and centrifugation at a density gradient.
The choice of the enzyme which is taken up in the coupling product, is determined by a number of properties of that enzyme. It is, of course, essential that the enzyme should be resistant to the coupling with another molecule, i.e., modification of one or more aminoacid side chains. Also of great importance is the specific activity of the enzyme. As less enzyme conjugate needs to be added to reach a measurable enzyme effect, the test system grows more sensitive. Further those enzymes are to be preferred, of which the determination of the activity can be made in a simple manner. In the first place those enzymes are considered that can be determined colorimetrically, spectrophotometrically or fluorimetrically. This kind of determinations is suitable for automation, which is an additional advantage.
Colorimetrically those enzymes can be determined that catalyze a reaction in which a coloured substance appears or disappears, either in the primary or in the secundary reaction.
As enzymes considered to act as enzymatically active component in conjugates, are mentioned catalase, peroxidase, ,B-glucoronidase, ,B-D-glucosidase, B-D- galactosidase, urease, glucose oxidase, galactose oxidase, and alkaline phosphatase.
At the end of the reaction between the components and the reagents according to the invention the enzyme activity of the liquid or solid phase of the reaction mixture or of the two phases can be determined. Most simple is, however, to determine the enzyme activity of the liquid phase.
The insoluble-made antibodies against the specific binding proteins, which are also an essential reagent for the process of the invention, can also be prepared in a known way. The antibodies can be prepared by taking a purified preparation of the specific binding protein,
or of proteins which have at least partly the same antigen properties as the specific binding protein, and injecting this in a known way into another animal species than from which it was obtained. The serum of the treated animal, or the gammaglobuline fraction thereof, can be made insoluble by cross-linking with compounds such as glutaric aldehyde and chloroformic acid ethyl ester, or by binding to solid carrier particles, either physically by adsorption, or chemically by the formation of covalent bonds. As solid carriers can be considered materials such as cellulose (modified or not), agarose, cross-linked dcxtran, polystyrene and the like. Covalent binding of the antibodies to these materials can be effected with the help of substances such as carbodiimides, diand tri-chloro-striazines, glutaric aldehyde, cyanogenbromide, and e.g., by diazotation.
The advantages of the method of determination found are done full justice if an excess of insoluble antibodies is applied, so that the specific binding protein passes completely into the solid phase.
The forms in which the reagents can be used are manifold. The enzyme-conjugated component of the reaction system can be freeze-dried, or dissolved in a buffer. Also a solid carrier can be used, e.g., a strip of paper impregnated with the conjugate. This applies equally to the required specific binding proteins.
The insoluble component can be brought in the form of particles of different dimensions, such as granules, flakes, rods, or in the form of a strip of some carrier material.
For the performing of the procedure according to the invention a test pack is applied by preference. This consists mainly of:
l. a known amount of a conjugate of an antigen, hapten or low-molecular bindable substance with an enzyme,
2. a corresponding amount of specific binding protein (antibodies or transport or receptor proteins),
3. a known amount of insoluble-made antibodies directed against the specific binding protein used. The test pack can further contain the reagents required for the enzyme determinations, and also auxiliary means for conducting the test, such as test tubes, pipettes and bottles with dilution liquid. Such a test pack is suitable for the determination ofa bindable substance, but also for the determination of a specific binding protein, in which case the specific binding protein contained in the test pack need not be used.
The test packs are especially frequently and with advantage used for the detection and determination of an antigen or hapten and to this end they contain mainly:
a. a known amount of a conjugate of the antigen or hapten and an enzyme,
b. a corresponding amount of corresponding antibodies,
c. a known amount of insoluble-made antibodies directed against the antibodies used. When applying such test packs for the detection and determination of antibodies the antibodies mentioned under (b) are not required.
An important embodiment of a test pack according to the present invention is a test pack to be used for the determination of gonadotropic hormones, and particularly for the determination of HCG (Human Chorionic Gonadotropin) as a means to diagnose pregnancy already in a very early stage, which test pack consists of an ampoule, tube, bottle or other container containing as essential ingredients, in separate lyophilized layers, pre-determined amounts of:
a. a conjugate of HCG with an enzyme, e.g., HCG- peroxidase.
b. anti-HCG.
0. antibodies against anti-HCG, made insoluble.
d. possibly other ingredients like a buffer.
By adding a certain amount of urine of a possibly pregnant woman to this test kit and to incubate the urine with the components of the kit a mixture of insoluble material is formed whereas the supernatant contains the remaining soluble HCG-enzyme conjugate. The amount of the latter is dependent on the amount of HCG in the urine to be tested. By determining the enzyme activity of this remaining HCG-enzyme conjugate it can be ascertained whether the urine is coming from a pregnant woman or not.
A preferably applied method for the determination of the enzyme activity consists in contacting an indicatorpaper impregnated with enzyme reagents, e.g., in case use is made of a peroxidase, a H O -supplier like urea- H ,O and a colour-reagent like o-tolidine.
By a correct choice of the amounts of each of the reagents it will be possible to ascertain pregnancy already in a very early stage and in a simple, rapid and very reliable way to be performed even by unskilled persons.
Example 1 Determination of human (HCG) a. Preparation of HCG-HRP. 5 mg HCG and 20 mg horse radish peroxidase (HRP) were dissolved in 2 ml 0.05 M phosphate buffer of pH 6.2. After addition of 40 ,ul 25% glutaric aldehyde solution the mixture was shaken for 2 hours at room temperature. After 5 minutes centrifugation at 250 g, the liquid was fractionated over Sephadex G-200 in 0.05 M phosphate buffer of pH 6.2. The fractions of which the highest percentage enzyme activity was bound by antibodies against HCG were used in the test system.
b. Preparation of antibodies against HCG. Antibodies against HCG were induced in rabbits as described by Schuurs et al. Acta Endocr. (Kbh.) 59, 120 (1968).
c. Preparation of antibodies against rabbit-yglobuline. Rabbit-y-globuline was isolated from normal rabbit serum by precipitation with 18% w/v solid sodium sulphate. Antibodies against this were prepared by immunizing a sheep according to the following schedule:
choriongonadotrophine amount Freunds adjuvans injection manner intramuscular intramuscular intramuscular intravenous intravenous On day the sheep was bled.
d. Preparation of the immunoadsorbent [sheep-anti- (rabbit-y-globulineH cellulose. The y-globuline fraction of the sheep serum described under 1 c) was prepared by precipitation with 16% w/v solid sodium sulphate. After washing, the precipitate was taken up in so much 0.05 M borate buffer of pH 8.6 that the resulting protein concentration amounted to 10 mg/ml. 350 mg m-aminobenzyloxymethylcellulose was suspended in 50 ml distilled water, and diazotized by adding 10 ml 36% hydrochloric acid and, dropwise, 10 ml 10% NaNO- solution at C. The suspension was centrifuged, washed and the precipitate re-suspended in 43 ml 0.05 M sodium borate of pH 8.6. Then 7 ml of the prepared y-globuline solution was added. The mixture was stirred for 26 hours at 4C, then centrifuged and washed with 0.02 M phosphate buffer of pH 6.0.
e. Determination of HCG. A dilution series (32-16-8-4-2-1-05-0 lU/ml) of HCG in 0.02 M phosphate buffer with pH 6.0 was prepared, which contained 2% v/v normal sheep serum. 0.5 ml of each of the HCG-containing samples was incubated with 0.1 ml rabbit-(anti-HCG) serum and 0.1 ml HCG-HRP conjugate, both in suitable dilution, for half an hour at room temperature. Then 0.3 ml of the immunoadsorbent 10 mg/ml) prepared acccording to d) was added, and the resulting mixture was rotated at room temperature for 1 hour. After centrifugation the enzyme activity in the supernatant was measured by mixing 0.5 ml of this liquid with 1.5 ml substrate (10 a1 30% H 0 and mg S-aminosalicylic acid in 150 ml 0.02 M phosphate buffer of pH 6.0) and after 30 minutes at C measuring the extinction at 460 nm. In this way it proved possible to detect a HCG concentration from 0.5 to 1 lU/ml in the sample. With this method also urine samples could be tested; the test is therefore suitable for a pregnancy check. The correlation with an existing method of test, a haemagglutination inhibiting test, was good. It proved possible to raise the sensitivity of the system by the application ofa pro-incubation. Here, first the sample only was incubated with the antiserum, and
then the HCG-HRP conjugate was added.
Example 11 Determination of insuline and anti-insuline.
a. Preparation of insuline-(glucose oxidase). 5 mg pig insuline and 25 mg glucose oxidase were dissolved in 2 ml 0.05 M phosphate buffer of pH 6.5. To this, 5 ,ul 25% glutaric aldehyde solution was added, after which the mixture was shaken for 90 minutes at room temperature. The mixture was fractionated over Sephadex G-200 in 0.05 M phosphate buffer of pH 6.5. The fractions of which the highest percentage of enzyme activity could be bound by antibodies against insuline, were used in the test system.
b. Preparation of antibodies against insuline. 1O
guinea pigs were given a weekly intramuscular injection with 1 mg pig insuline in complete Freunds adjuvans over a period from 4-8 weeks. After two weeks rest the animals were given 1 mg additional insuline by intravenous injection without adjuvans. 2 weeks after that the animals were bled. Hypoglycaemia occurring at times was counteracted by intraperitoneal administration of glucose.
0. Preparation of antibodies against guinea pig y-globuline. Guinea pig y-globuline was prepared by adding 1 volume saturated ammonium sulphate solution to 2 volumes guinea pig serum. The precipitate formed was twice washed with 33% saturated ammonium sulphate solution, and then taken up in a physiological salt solution. A sheep was immunized with increasing doses of the prepared 'y-globuline: 0.5, 1 and 2 mg. The injections were given every two weeks, whilst the immunogen was mixed with complete Freunds adjuvans. Two weeks after the last injection an additional 2 mg y-globuline in a physiological salt solution were given, and 1 week later the animal was bled.
d. Preparation of insoluble antibodies against guinea pig y-globuline. 10 g microcrystalline cellulose was activated by adding it whilst stirring to 400 ml 2.5% w/v CNBr-solution, after which the pH was brought to 10.5 with 1 N NaOH solution and maintained thus for 2 minutes. Then the cellulose was washed with ice water and with 0.1 M NaHCO;,. To 10 ml sheep-anti( guinea pig y-globuline) serum 1.6 g
Na SO was added. After 1 hour stirring at room temperature the precipitate was centrifuged, twice washed with 20 ml 16% w/v Na SO solution, and subsequently taken up in 10 ml 0.1 M NaHCO;,. The activated cellulose was mixed with 40 ml 0.1 M NaHCO;, solution and the 10 ml y-globuline solution. This suspension was rotated for 40 hours at 4C, and in succession washed with twice 500 ml 0.5 M NaHCO;; twice 500 ml 0.05 M citrate pH 1.1, and twice 500 ml 0.05 M phosphate of pH 6.2.
e. Determination of antibodies against insu1ine. 0.1
ml insuline-(glucose oxidase), in a suitable dilution, was incubated with 0.4 m1 of a dilution series of a guinea pig anti-insuline serum for 4 hours. The dilution series was made with 0.05 M phosphate buffer of pH 6.0. Then 0.3 ml immunoadsorbent (15 mg/ml) and 0.2 ml buffer were added and the mixture was rotated during the night at 4C. After centrifuging the enzyme activity of the supernatant was determined by incubating 0.5 ml of same with 2.5 ml substrate for 30 minutes, and then measuring the extinction at 460 nm. The substrate con tained 50 mg glucose, 10 ug peroxidase and 1 mg S-aminosalicyclic acid per 2.5 ml 0.05 M phosphate buffer of pH 6.0. By means of this system the antibody content of the different serums could be intercompared. As reference point was chosen the serum dilution at which 50% of the total combinable enzyme activity is bound.
f. Determination of insuline. 0.2 ml of a dilution series of insuline was incubated for 2 hours with 0.4 ml anti-insuline serum in such a dilution that it could bind 60% of the enzyme conjugate to be added. Then 0.1 ml insuline-(glucose oxidase) was added in the corresponding dilution, and incubated for 4 hours. Finally 0.3 ml immunoadsorbent (15 mg/ml) was added. The mixture was rotated during the night at 4C. After centrifuging the enzyme activity of the supernatant was measured as described under (e). The sensitivity of the determination, which depends on the antiserum used, lies in the nanogram range: 20-100 ng/ml, i.e., 0.5-2.5 mU/ml.
Example 11] Determination of oestradiol.
a. Preparation of oestradiol-17-succinyl-HRP. 50 mg oestradiol-17-hemisuccinate and 0.08 ml tri-nbutylamine were dissolved in 2.5 ml dioxane. To the cold (2C) solution 15 pl isobutylchlorocarbonate was added. After 30 minutes this solution was mixed with 100 mg horse radish peroxidase (HRP) in 7.5 ml of a dioxanc/water mixture (2:3) which had been adjusted to pH 9.5 with sodium hydroxide. The solution was stirred for 4 hours at 2C, and then dialyzed for 18 hours. The precipitate formed after the pH of the dialysate had been adjusted to 4.6, was centrifuged, washed and taken up in 5 ml distilled water that had been adjusted to pH 8. The material was further purified by twice precipitating with ml acetone. The finished product was taken up in 10 ml 0.05 M phosphate buffer of pH 7.8.
b. Preparation of oestradiol-l7-succinyl-BSA. The
(1. Preparation of antibodies preparation was prepared according to the mixed anhydride method, as described in Example llla. This preparation was made starting from 100 mg oestradiol-l7-hemisuccinate and 150 mg bovine serum albumine (BSA).
. Preparation of antibodies against oestradiol. A
sheep was injected once in four weeks with 4 mg oestradiol-l7-succinyl-BSA in complete Freunds adjuvans. At regular intervals blood was taken from the sheep. The serum was absorbed with BSA that was made insoluble.
against sheep-yglobuline. Sheep-y-globuline was prepared as described in example I, but now with 16% w/v sodium sulphate. Rabbits were immunized with this sheepy-globuline according to the following schedule:
day amount Freunds adjuvans injection manner 0 200 .1g intramuscular 14 400 .1g intramuscular 28 800 g intramuscular 42 800 ig intravenous 2 weeks after the last injection the animals were bled.
e. Preparation of the immunoadsorbent [rabbit-anti(- sheep-y-globuline)l-cellulose. The y-globuline fraction of the antiscrums, described under (d), was prepared by precipitation with 18% w/v Na S0,. The product obtained was coupled to cellulose according to the Gurvich method, described in example 1.
. Determination of oestradiol. The immune reaction was made in 0.02 M phosphate buffer of pH 6.0, which contained 2% BSA: 0.5 ml sample was mixed .with 0.1 ml of the sheep-anti-oestradiol serum in the quality of the oestradiol-17-succinyl-HRP used. With a dilution of 1:12.800 of the antiserum an oestradiol concentration of 10 ng/ml could be detected in the sample. Oestriol and oestron showed a cross reaction in this system.
Example lV Determination of cortisol and corticoid-binding globuline.
a. Preparation of cortisol-2l-(galactose oxidase). 50
mg cortisol-2l-hemisuccinate and mg galatose oxidase were coupled by means of the mixed anhydride technique, as described in example llla.
b. Corticoid-binding globuline (CBG) was isolated from the serum of men by means of chromatography in succession over DEAE-cellulose and hydroxyl apatite. Antibodies against this were prepared by injecting rabbits at 14-day intervals with 500 ug CBG in complete Freunds adjuvans. After 3 months the animals were injected with 1 mg CBG and 2 weeks later they were bled.
c. The y-globuline fraction of anti-CBG serum was coupled to m-aminobenzyloxymethylcellulose, as described in example lll.
d. Determination of cortisol. 0.5 ml of a cortisolcontaining sample (standard solution) was extracted with 2 X 3 ml methylenechloride. The combined extraction liquids were evaporated to dryness. The residue was taken up in 0.5 ml 0.05 M phosphate buffer of pH 6.2, then mixed with 0.1 ml of a solution of CBG in the same buffer in a suitable concentration, and incubated for 30 minutes at 4C. Then 0.1 ml cortisol-Zl-(galactose oxidase), also in a suitable dilution, and 0.3 ml of the immunoadsorbent prepared under (0) with a concentration of 5 mg/ml were added. The mixture obtained was rotated for 2 hours at 4C and then centrifuged, after which the enzyme activity was measured in the supernatant. To this end 0.5 ml of same was added to 1.5 ml substrate consisting of 100 mg D-galactose, 20 mg 5-aminosalicyclic acid and 10 pg peroxidase in ml 0.02 M phosphate buffer of pH 6.0. After 30 minutes the extinction was measured at 460 nm. When applying 21 CBG concentration of 0.4 ig/ml and so much cortisol- 21-( galactose oxidase) that without the addition of steroids 80% of the enzyme conjugate was bound to the immunoadsorbent, it proved possible to determine amounts from 3-30 ng cortisol.
e. Determination of CBG was also possible with the reagents described. From a dilution series of transcortine, ranging from 0-1280 ng/ml, 0.5 ml was incubated for 15 minutes with 0.2 ml cortisol-21- (galactose oxidase) in a suitable dilution. Then 0.3 ml immunoadsorbent suspension (5 mg/ml) was added, and the mixture rotated for 15 minutes. The two incubations were conducted at 4C. Then the enzyme activity in the supernatant was measured as under d). The sensitivity of the test system proved to be 50 ng/ml.
Example V In a bottle the following reagents were subsequently 65 lyophilized in separate layers:
1. 0.3 ml of the immunoadsorbent suspension (10 mg/ml) as described in Example 1 a).
2. 0.1 ml of a 1% mannitol solution.
3. 0.l ml of HCG-HRP as described in Example I (a).
4. a second layer of 0.1 ml of a 1% mannitol solution.
5. 0.1 ml of rabbit (anti-HCG) serum described in Example I (b).
To this lyophilized mixture 0.5 ml of a urine sample and subsequently 0.5 ml distilled water was added. After minutes the enzyme activity in the supernatant was measured by means of a slip of paper impregnated with urea-hydrogenperoxide and o-tolidine.
If the urine sample was coming from a pregnant woman 2 lU l-lCG/ml) a blue colour appeared within 5 minutes, whereas in case of urine of a nonpregnant woman no discoloration took place within the same period.
We claim:
1. Process for the detection and determination of a bindable substance selected from the group consisting of an antigen and a hapten, comprising the steps of:
a. providing a given quantity of a conjugate of said bindable substance with an enzyme;
b. providing a corresponding given quantity of an antibody against said bindable substance;
c. admixing a sample of a fluid containing the bindable substance to be determined with the reactants of steps (a) and (b) to form a reaction mixture and allowing the reaction to go to completion;
d. separating the resulting mixture into a liquid phase and a solid phase by adding an insolubilized antibody against the antibody of step (b); and
e. determining the quantity of the bindable substance from the measure of enzyme activity of either separated phase.
2. The process of claim 1 in which the bindable substance is determined by first adding thereto the antibody, then the enzyme conjugate, and finally the insoluble antibody against the antibody.
3. Process for the detection and determination of an antibody in a fluid sample containing the same utilizing the reaction between said antibody and a bindable substance selected from the group consisting of an antigen and a hapten having an affinity therefor, comprising the steps of:
a. providing a given quantity of a conjugate of said bindable substance and an enzyme;
b. providing a given quantity of an insolubilized antibody against the antibody to be determined;
0. admixing said given quantities of steps (a) and (b) with said sample, and allowing the components to react;
d. separating the reaction mixture into a liquid phase and a solid phase; and e. determining the quantity of the antibody from the measure of enzyme activity of either separated 5 phase.
4. A test pack for the detection and determination of a bindable substance selected from the group consisting of an antigen and a hapten in a fluid sample, comprising:
a. a known amount of a conjugate of said bindable substance with an enzyme; b. a corresponding known amount of an antibody against said antigen or hapten; c. a known amount of an insolubilized antibody 15 against said antibody; d. a stabilizer; and e. a substrate for the determination of the enzyme activity and thus of the quantity of the antigen or hapten to be determined.
5. A test pack for the detection and determination of an antibody in a fluid sample, utilizing the reaction between said antibody and an antigen or hapten to said antibody, comprising:
a. a known amount of a conjugate of the antigen or hapten with an enzyme;
b. a corresponding known amount of an insolubilized antibody against the antibody to be determined;
c. a stabilizer; and 3 d. a substrate for the determination of the enzyme activity and thus of the quantity of antibody to be determined.
6. A test pack for the determination of pregnancy by the detection and determination of human chorionic gonadotropin in a sample of urine, utilizing the reaction between human chorionic gonadotropin-and an antibody therefor, comprising, in separate lyophilized layers:
a. a predetermined amount of a conjugate of human chorionic gonadotropin and an enzyme;
b. a predetermined amount of an antibody against human chorionic gonadotropin;
c. a predetermined amount of an antibody against the human chorionic gonadotropin antibody, in insolubilized form;
d. a stabilizer; and
e. a substrate for the determination of the enzyme activity and thus of the quantity of human chorionic gonadotropin enzyme conjugate and human chorionic gonadotropin to be determined.

Claims (6)

1. PROCESS FOR THE DETECTION AND DETERMINATION OF A BINDABLESUBSTANCE SELECTED FROM THE GROUP CONSISTING OF AN ANTIGEN AND A HAPTEN, COMPRISING THE STEPS OF: A. PROVIDING A GIVEN AQUNTITY OF A CONJUGATE OF SAID BINDABLE SUBSTANCE WITH AN ENZYME; B. PROVIDING A CORRESPONDING GIVEN QUANTITY OF AN ANTIBODY AGAINST SAID BINDABLE SUBSTANCE; C. ADMIXING A SAMPLE OF A FLUID CONTAINING THE BINDABLE SUBSTANCE TO BE DETERMINED WITH THE REACTANTS OF STEPS(A) AND (B) TO FORM A REACTION MIXTURE AND ALLOWING THE REACTION TO GO TO COMPLETION; D. SEPARATING THE RESULTING MIXTURE INTO A LIQUID PHASE AND A SOLID PHASE BY ADDING AN INSOLUBLIZED ANTIBODY AGAINST THE ANTIBODY OF STEP (B); AND E. DETERMINING THE QUANTITY OF THE BINDABLE SUBSTANCE FORM THE MEASURE OF ENZYME ACTIVITY OF EITHER SEPARATED PHASE.
2. The process of claim 1 in which the bindable substance is determined by first adding thereto the antibody, then the enzyme conjugate, and finally the insoluble antibody against the antibody.
3. Process for the detection and determination of an antibody in a fluid sample containing the same utilizing the reaction between said antibody and a bindable substance selected from the group consisting of an antigen and a hapten having an affinity therefor, comprising the steps of: a. providing a given quantity of a conjugate of said bindable substance and an enzyme; b. providing a given quantity of an insolubilized antibody against the antibody to be determined; c. admixing said given quantities of steps (a) and (b) with said sample, and allowing the components to react; d. separating the reaction mixture into a liquid phase and a solid phase; and e. determining the quantity of the antibody from the measure of enzyme activity of either separated phase.
4. A test pack for the detection and determination of a bindable substance selected from the group consisting of an antigen and a hapten in a fluid sample, comprising: a. a known amount of a conjugate of said bindable substance with an enzyme; b. a corresponding known amount of an antibody against said antigen or hapten; c. a known amount of an insolubilized antibody against said antibody; d. a stabilizer; and e. a substrate for the determination of the enzyme activity and thus of the quantity of the antigen or hapten to be determined.
5. A test pack for the detection and determination of an antibody in a fluid sample, utilizing the reaction between said antibody and an antigen or hapten to said antibody, comprising: a. a known amount of a conjugate of the antigen or hapten with an enzyme; b. a corresponding known amount of an insolubilized antibody against the antibody to be determined; c. a stabilizer; and d. a substrate for the determination of the enzyme activity and thus of the quantity of antibody to be determined.
6. A test pack for the determination of pregnancy by the detection and determination of human chorionic gonadotropin in a sample of urine, utilizing the reaction between human chorionic gonadotropin and an antibody therefor, comprising, in separate lyophilized layers: a. a predetermined amount of a conjugate of human chorionic gonadotropin and an enzyme; b. a predetermined amount of an antibody against human chorionic gonadotropin; c. a predetermined amount of an antibody against the human chorionic gonadotropin antibody, in insolubilized form; d. a stabilizer; and e. a substrate for the determination of the enzyme activity and thus of the quantity of human chorionic gonadotropin enzyme conjugate and human chorionic gonadotropin to be determined.
US00206952A 1970-12-28 1971-12-10 Process for the detection and determination of specific binding proteins and their corresponding bindable substances Expired - Lifetime US3839153A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
NL707018838A NL154599B (en) 1970-12-28 1970-12-28 PROCEDURE FOR DETERMINING AND DETERMINING SPECIFIC BINDING PROTEINS AND THEIR CORRESPONDING BINDABLE SUBSTANCES, AND TEST PACKAGING.

Publications (1)

Publication Number Publication Date
US3839153A true US3839153A (en) 1974-10-01

Family

ID=19811894

Family Applications (1)

Application Number Title Priority Date Filing Date
US00206952A Expired - Lifetime US3839153A (en) 1970-12-28 1971-12-10 Process for the detection and determination of specific binding proteins and their corresponding bindable substances

Country Status (20)

Country Link
US (1) US3839153A (en)
JP (3) JPS5834783B1 (en)
AT (1) AT320145B (en)
AU (1) AU467394B2 (en)
BE (1) BE777309A (en)
BR (1) BR7108553D0 (en)
CA (1) CA964560A (en)
CH (1) CH557030A (en)
DE (1) DE2164768B2 (en)
DK (1) DK150690C (en)
EG (1) EG11604A (en)
ES (1) ES398372A1 (en)
FI (1) FI54034C (en)
FR (1) FR2120835A5 (en)
GB (1) GB1348938A (en)
IL (1) IL38371A (en)
IT (1) IT965020B (en)
NL (1) NL154599B (en)
SE (1) SE398557B (en)
ZA (1) ZA718332B (en)

Cited By (836)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3935074A (en) * 1973-12-17 1976-01-27 Syva Company Antibody steric hindrance immunoassay with two antibodies
US4001087A (en) * 1974-10-10 1977-01-04 The United States Of America Affinity labelling enzymes with esters of aromatic sulfonic acids
US4002532A (en) * 1974-10-21 1977-01-11 Weltman Joel K Enzyme conjugates
FR2325934A1 (en) * 1975-09-29 1977-04-22 Cordis Corp METHOD OF DETECTION OF THE PRESENCE OF AN ANTIGEN ASSOCIATED WITH HEPATITIS
US4040907A (en) * 1974-06-20 1977-08-09 Syva Company Iodothyronine enzyme conjugates
US4045384A (en) * 1976-07-23 1977-08-30 The Dow Chemical Company Method for forming an amide bond between a latex and protein
FR2373795A1 (en) * 1976-12-10 1978-07-07 Erba Carlo Spa IMMUNOLOGICAL DOSAGE BY FIXED ENZYME
FR2390732A1 (en) * 1977-05-12 1978-12-08 Sclavo Inst Sieroterapeut PROCESS FOR DETERMINING THE CONTENTS OF CERTAIN COMPONENTS OF BIOLOGICAL FLUIDS AND MEANS USED
US4162003A (en) * 1973-06-30 1979-07-24 Dezso Istvan Bartos Ready-for-use rapid test package for serological tests
FR2434201A1 (en) * 1978-04-05 1980-03-21 Syva Co PROCESS AND NECESSARY FOR IMMUNOLOGICAL DETERMINATION AND ASSAY OF A SUBSTANCE BY CREATING A CONCENTRATED MICRO-ENVIRONMENT
FR2435716A1 (en) * 1978-04-05 1980-04-04 Syva Co METHOD AND COMPOSITION FOR IMMUNOLOGICAL ASSAY USING A SOLID DISPERSABLE PARTICLE CONJUGATE, AN ORGANIC COMPOUND OR THE CORRESPONDING RECEPTOR
US4200690A (en) * 1976-12-16 1980-04-29 Millipore Corporation Immunoassay with membrane immobilized antibody
US4200508A (en) * 1977-02-09 1980-04-29 Hidematsu Hirai Method and composition for detecting antigenic substances
US4230797A (en) * 1975-04-28 1980-10-28 Miles Laboratories, Inc. Heterogenous specific binding assay employing a coenzyme as label
WO1980002747A1 (en) * 1979-05-31 1980-12-11 Rapidex Ltd Ultrasensitive enzymatic radioimmunoassay method
US4239746A (en) * 1973-06-30 1980-12-16 Dezso Istvan Bartos Complement fixation test employing reactants in a disposable package
EP0023989A1 (en) * 1979-07-28 1981-02-18 Medac Gesellschaft für klinische Spezialpräparate mbH Enzyme-immuno assay for the detection of pathogen specific antibodies and test-kit for performing this assay
US4260678A (en) * 1979-02-23 1981-04-07 Corning Glass Works Determining creatine kinase isoenzmes via immobilized antibody-isoenzyme complexes
EP0032286A2 (en) * 1979-12-26 1981-07-22 Syva Company Method for analysis for a member of an immunological pair using a test surface; kit and test surface material therefor
US4298687A (en) * 1978-10-31 1981-11-03 Roland Maes Process for the determination of compounds showing among themselves specific binding affinities by the use of a solid phase
US4298685A (en) * 1978-05-04 1981-11-03 Burroughs Wellcome Co. Diagnostic reagent
EP0040365A1 (en) * 1980-05-19 1981-11-25 Pharmacia Diagnostics Ab An assaying method involving biospecific affinity reactions
EP0040728A1 (en) * 1980-05-19 1981-12-02 Pharmacia Diagnostics Ab An improvement in and relating to assaying methods involving biospecific affinity reactions
US4318980A (en) * 1978-04-10 1982-03-09 Miles Laboratories, Inc. Heterogenous specific binding assay employing a cycling reactant as label
US4322495A (en) * 1980-03-11 1982-03-30 Minnesota Mining And Manufacturing Co. Immunoassay
US4323647A (en) * 1980-10-15 1982-04-06 University Of Miami Steric hindrance enzyme immunoassay
EP0054675A1 (en) * 1980-12-23 1982-06-30 Roche Diagnostics GmbH Process for enzyme immuno-determination in the heterogeneous phase
USRE31006E (en) * 1968-09-24 1982-08-03 Akzona Incorporated Process for the demonstration and determination of reaction components having specific binding affinity for each other
US4343896A (en) * 1975-02-01 1982-08-10 Akzona Incorporated Method and test pack for the demonstration and determination of an antigen or antibody
US4350761A (en) * 1979-05-18 1982-09-21 Yamasu Shoyu Kabushiki Kaisha Method of and reagents for quantitative analysis of cyclic nucleotides
WO1982004323A1 (en) * 1981-06-02 1982-12-09 O Neill Sean Immunoprecipitation assay
US4394391A (en) * 1980-02-19 1983-07-19 Thorell Jan Ivan Radioimmunoassay reagents
US4407943A (en) * 1976-12-16 1983-10-04 Millipore Corporation Immobilized antibody or antigen for immunoassay
US4443365A (en) * 1980-07-01 1984-04-17 Dainippon Pharmaceutical Company Limited Method for determination of the valproic acid and reagents therein
US4474878A (en) * 1975-09-29 1984-10-02 Cordis Laboratories, Inc. Sandwich EIA for antigen associated with hepatitis
EP0124352A2 (en) * 1983-04-29 1984-11-07 TECHNICON INSTRUMENTS CORPORATION(a Delaware corporation) Protected binding assay
US4492751A (en) * 1978-04-10 1985-01-08 Miles Laboratories, Inc. Heterogenous specific binding assay employing an enzyme substrate as label
US4506009A (en) * 1982-03-30 1985-03-19 University Of California Heterogeneous immunoassay method
US4515890A (en) * 1982-11-08 1985-05-07 Abbott Laboratories Immunoassay of terminal deoxynucleotidyl transferase
US4535057A (en) * 1982-07-26 1985-08-13 Amf Incorporated Immunoassay employing monoclonal herpes simplex antibody and biotin-avidin detection system
US4604365A (en) * 1981-06-02 1986-08-05 Electro-Nucleonics, Inc. Immunoprecipitation assay
US4629688A (en) * 1975-04-28 1986-12-16 Miles Laboratories, Inc. Homogeneous specific binding assay method
US4642285A (en) * 1975-09-29 1987-02-10 Diamedix Corporation Sandwich EIA for antigen
USRE32696E (en) * 1975-09-04 1988-06-14 Akzona Incorporated Enzymatic immunological method for determination of antigens and antibodies
US4778752A (en) * 1983-10-11 1988-10-18 Scripps Clinic And Research Foundation Receptors specific for hapten-modified self proteins
US4937199A (en) * 1985-03-18 1990-06-26 The Royal Free Hospital School Of Medicine Detection of viruses and antibodies
US4956303A (en) * 1986-04-28 1990-09-11 Antibody Technology Limited Secondary antibodies against complexes of small molecules and binding partners therefor, their preparation, and their use in diagnostic methods
EP0524502A2 (en) 1991-07-22 1993-01-27 Bayer Corporation Immunoassay for free analyte
US5256372A (en) * 1987-11-06 1993-10-26 Idexx Corporation Dipstick test device including a removable filter assembly
US5587294A (en) * 1991-07-19 1996-12-24 Assay Research, Inc. Method and kit for measuring endogenous cytokines
US5605800A (en) * 1978-04-13 1997-02-25 Institut Pasteur Method of detecting and characterizing a nucleic acid or a sequence of the latter, and enzymatic reactant for the application of this method
US5607565A (en) * 1995-03-27 1997-03-04 Coulter Corporation Apparatus for measuring analytes in a fluid sample
US5614504A (en) * 1990-08-01 1997-03-25 The University Of South Florida Method of making inosine monophosphate derivatives and immunopotentiating uses thereof
US5637467A (en) * 1992-10-13 1997-06-10 Behringwerke Ag Heterogeneous assay using a pendulous drop
US5728807A (en) * 1995-05-16 1998-03-17 Ramot-University Authority For Applied Research And Industrial Development, Ltd. Mutated proteins associated with ataxia-telangiectasia
US5777093A (en) * 1995-05-16 1998-07-07 Ramot-University Authority For Applied Research & Industrial Development Ltd. cDNAs associated with ataxia-telangiectasia
US5837535A (en) * 1994-06-13 1998-11-17 Henry Ford Health System Neuronal-neonatal gene: neuronatin
US5840322A (en) * 1996-12-19 1998-11-24 Ramot-University Authority For Applied Research & Industrial Devel. Ltd. Anti-oral-microbial adhesion fraction derived from vaccinium
US5843673A (en) * 1994-10-25 1998-12-01 Curators Of The University Of Missouri Method of screening for endometriosis
US5858661A (en) * 1995-05-16 1999-01-12 Ramot-University Authority For Applied Research And Industrial Development Ataxia-telangiectasia gene and its genomic organization
US5874423A (en) * 1992-09-10 1999-02-23 Yissum Research Development Co. Of The Hebrew University Of Jerusalem Digitalis-like compounds
US5876928A (en) * 1978-04-13 1999-03-02 Institut Pasteur Method of detecting and characterizing a nucleic acid or a sequence of the latter, and enzymatic reactant for the application of this method
US5965379A (en) * 1991-07-19 1999-10-12 Cytimmune Sciences Inc. Method for measuring endogenous cytokines
US6096508A (en) * 1995-08-16 2000-08-01 Kirkegaard & Perry Laboratoies, Inc. Method of reducing background in biotin-based assays
US6187563B1 (en) 1998-08-07 2001-02-13 Yale University βIV-spectrin-polypeptides and nucleic acids encoding same
US6284496B1 (en) 1997-10-03 2001-09-04 University Of South Florida DNA vector for determining the presence of out-of-reading-frame mutations
US6344443B1 (en) 1998-07-08 2002-02-05 University Of South Florida Peptide antagonists of tumor necrosis factor alpha
WO2002044736A2 (en) 2000-11-30 2002-06-06 Molecular Skincare Limited Diagnosis and treatment of epidermal or skin diseases
US6440682B1 (en) * 1999-05-28 2002-08-27 Detroit R&D Inc. Detection of hypertension using immunoreactive metabolic products
US20020142287A1 (en) * 2000-12-14 2002-10-03 Hirotaka Yamamoto High throughput assay to detect inhibitors of the map kinase pathway
US6482389B1 (en) 1997-10-17 2002-11-19 University Of South Florida Method to diagnose and monitor cellular immune deficiencies
US6528292B1 (en) * 1987-05-29 2003-03-04 Aventis Pharmaceuticals Holdings Inc. Derivatized polystyrene and other polymer supports for spectroscopic studies
US6531277B2 (en) 1994-10-25 2003-03-11 The Curators Of The University Of Missouri Endometriosis-specific secretory protein
US20030064058A1 (en) * 2001-09-07 2003-04-03 Nadir Askenasy Methods of utilizing bone marrow stem cells for inducing immunological tolerance
US6555667B1 (en) 1997-08-21 2003-04-29 Quark Biotech, Inc. Hypoxia-regulated genes
US20030086914A1 (en) * 1999-06-25 2003-05-08 Yissum Research Development Company Of The Hebrew University Of Jerusalem Method and device for inducing biological processes by micro-organs
US20030104491A1 (en) * 2000-04-30 2003-06-05 Cabantchik Ioav Zvi Molecules and methods using same for measuring non-transferrin bound iron
US20030114410A1 (en) * 2000-08-08 2003-06-19 Technion Research And Development Foundation Ltd. Pharmaceutical compositions and methods useful for modulating angiogenesis and inhibiting metastasis and tumor fibrosis
US20030152909A1 (en) * 1994-11-16 2003-08-14 Mitrani Eduardo N. In vitro micro-organs, and uses related thereto
US20030211490A1 (en) * 2000-01-24 2003-11-13 Hanan Stein Plants tolerant of environmental stress conditions, methods of generating same and novel polynucleotide sequence utilized thereby
US20040052928A1 (en) * 2002-09-06 2004-03-18 Ehud Gazit Peptides and methods using same for diagnosing and treating amyloid-associated diseases
US20040052769A1 (en) * 2000-11-30 2004-03-18 Yair Reisner Methods of utilizing cultured non-gvhd inducing t lymphocytes to treat disease
US20040078842A1 (en) * 2001-01-17 2004-04-22 Aviah Zilberstein Chitinases, derived from carnivorous plants polynucleotide sequences encoding thereof, and methods of isolating and using same
US20040121442A1 (en) * 2002-05-05 2004-06-24 Ilan Chet Fungal chitinase, polynucleotide sequences encoding same, promoters of same, and uses thereof
WO2004060135A2 (en) 2003-01-02 2004-07-22 Rappaport Family Institute For Research In The Medical Sciences Methods of predicting a benefit of antioxidant therapy for prevention of cardiovascular disease in hyperglycemic patients
US20040146949A1 (en) * 2002-10-25 2004-07-29 Jun Tan Methods and compounds for disruption of CD40R/CD40L signaling in the treatment of alzheimer's disease
US6770622B2 (en) 2001-06-08 2004-08-03 Gary A. Jarvis N-terminally truncated galectin-3 for use in treating cancer
US6787318B1 (en) 1999-06-01 2004-09-07 Roskamp Research Institute, Llc Assay for evaluating the therapeutic effectiveness of agents in reducing Alzheimer's disease pathology
US20040197334A1 (en) * 2003-04-02 2004-10-07 Technion Research & Development Foundation Ltd. Antibody fragment capable of modulating multidrug resistance and compositions and kits and methods using same
US20050008624A1 (en) * 2002-01-24 2005-01-13 Tony Peled Expansion of renewable stem cell populations
US20050022269A1 (en) * 2001-07-19 2005-01-27 Joseph Hirschberg Polypeptides having carotenoids isomerase catalytic activity, nucleic acids encoding same and uses thereof
US20050020499A1 (en) * 2003-05-27 2005-01-27 Bar Ilan University Methods of attenuating cocaine seeking behavior employing glial cell-derived neurotrophic factor (GDNF) and pharmaceutical compositions and articles of manufacture suited for use in practice of the method
US20050031618A1 (en) * 2001-01-31 2005-02-10 Dror Mevorach Induction of tolerance by apoptotic and/or necrotic cells
US20050054097A1 (en) * 2002-11-17 2005-03-10 Tony Peled EX-VIVO expansion of hematopoietic system cell populations in mononuclear cell cultures
US20050054103A1 (en) * 2003-03-07 2005-03-10 Tony Peled Expansion of renewable stem cell populations using modulators of PI 3-kinase
US6875582B1 (en) 1999-08-19 2005-04-05 Omniscience Pharmaceuticals, Inc. Methods and targets of antibiotic resistance
WO2005033142A2 (en) 2003-10-07 2005-04-14 Yeda Research And Development Co. Ltd. Anti-nik antibodies and uses thereof
WO2005033145A1 (en) 2003-10-07 2005-04-14 Yeda Research And Development Co. Ltd. Antibodies to nik, their preparation and use
US20050085432A1 (en) * 2001-12-26 2005-04-21 Aviva Lapidot Methods of using conjugates of saccharides and acetamidino or guanidino compounds for treating bacterial infections
US20050113327A1 (en) * 1999-08-30 2005-05-26 Levava Roiz Methods of and compositions for inhibiting the proliferation of mammalian cells
WO2005051423A2 (en) 2003-11-30 2005-06-09 Yeda Research And Development Co. Ltd Methods and agents for immune modulation and methods for identifying immune modulators
US20050152912A1 (en) * 2003-03-26 2005-07-14 Technion Research & Development Foundation Ltd. Compositions capable of specifically binding particular human antigen presenting molecule/pathogen-derived antigen complexes and uses thereof
US20050158822A1 (en) * 2004-01-20 2005-07-21 Insight Biopharmaceuticals Ltd. High level expression of recombinant human erythropoietin having a modified 5'-UTR
US20050176143A1 (en) * 1999-02-04 2005-08-11 Technion Research & Development Method and apparatus for maintenance and expansion of hemopoietic stem cells and/or progenitor cells
US20050202098A1 (en) * 2001-01-31 2005-09-15 Tolaren Disease therapy using dying or dead cells
US20050220774A1 (en) * 2002-03-18 2005-10-06 Tony Peled Methods of inducing differentiation in ex vivo expanded stem cells
US20050255101A1 (en) * 2002-02-13 2005-11-17 Technion Research And Development Foundation Ltd. Antibody having a t-cell receptor-like specificity, yet higher affinity, and the use of same in the detection and treatment of cancer, viral infection and autoimmune disease
US20050271643A1 (en) * 2003-08-14 2005-12-08 Iryna Sorokulova Bacterial strains, compositions including same and probiotic use thereof
US20060019340A1 (en) * 1999-06-08 2006-01-26 David Naor CD44 polypeptides, polynucleotides encoding same, antibodies directed thereagainst and method of using same for diagnosing and treating inflammatory diseases
US6998232B1 (en) 1999-09-27 2006-02-14 Quark Biotech, Inc. Methods of diagnosing bladder cancer
US20060035980A1 (en) * 2003-04-18 2006-02-16 Scanlan Thomas S Thyronamine derivatives and analogs and methods of use thereof
US20060039897A1 (en) * 2002-03-26 2006-02-23 Tamar Lotan Stinging cells expressing an exogenous polycleotide encoding a therpeutic, diagnostics or a cosmetic agent and methods compositions and devices utilizing such stinging cells or capsules derive therefrom for delivering the therapeutic, diagnostic or cosmetic agent into a tissue
US20060051426A1 (en) * 2001-12-05 2006-03-09 Gershon Golomb Nanoparticles containing polymeric nucleic acid homologs pharmaceutical composition and articles of manufacture containing same and methods of use thereof
US20060079941A1 (en) * 2004-10-12 2006-04-13 Eli Ovsyshcher Methods and implantable devices for treating supraventricular arrhythmias
US20060095241A1 (en) * 2004-10-29 2006-05-04 Microsoft Corporation Systems and methods that utilize machine learning algorithms to facilitate assembly of aids vaccine cocktails
US20060099273A1 (en) * 2000-09-28 2006-05-11 Nanocyte Inc. Sterile preparations and compositions including stinging capsules and methods of producing and using same
US20060123516A1 (en) * 2003-05-22 2006-06-08 Gil Ronen Methods of increasing abiotic stress tolerance and/or biomass in plants and plants generated thereby
US20060127366A1 (en) * 1999-06-25 2006-06-15 Mitrani Eduardo N Method and device for inducing biological processes by micro-organs
US20060134680A1 (en) * 2004-12-22 2006-06-22 Alexander Kotlyar Homogeneous populations of nucleic acids, methods of synthesyzing same and uses thereof
US20060148078A1 (en) * 2002-11-29 2006-07-06 Sharon Gerecht-Nir Method of dynamically culturing embryonic stem cells
US20060159769A1 (en) * 2000-09-28 2006-07-20 Nanocyte Inc. Methods compositions and devices utilizing stinging cells/capsules for delivering a therapeutic or a cosmetic agent into a tissue
EP1683874A2 (en) 2000-08-29 2006-07-26 YEDA RESEARCH AND DEVELOPMENT Co. LTD. Methods of isolating genes encoding proteins of specific function and of screening for pharmaceutically active agents
US7087395B1 (en) 2001-01-16 2006-08-08 Quest Diagnostics Investments Incorporated Vitamin D assay
WO2006090388A2 (en) 2005-02-25 2006-08-31 The State Of Israel, Ministry Of Agriculture & Rural Development, Agricultural Research Organization, (A.R.O.), Volcani Center Fruit cell culture extract for treating inflammation
US7101839B1 (en) 1999-08-30 2006-09-05 Yissum Research Development Company Of The Hebrew University Of Jerusalem Methods of and compositions for inhibiting the proliferation of mammalian cells
US20060211064A1 (en) * 2005-03-18 2006-09-21 Hyesook Kim Detection of hypertension using glucuronidated metabolic products
US20060234203A1 (en) * 2005-04-19 2006-10-19 Nanocyte Inc. Methods, compositions and devices utilizing stinging cells/capsules for conditioning a tissue prior to delivery of an active agent
US20060234947A1 (en) * 2002-01-31 2006-10-19 Tel Aviv University Future Technology Development L.P Peptides antibodies directed thereagainst and methods using same for diagnosing and treating amyloid-associated diseases
US20060246524A1 (en) * 2005-04-28 2006-11-02 Christina Bauer Nanoparticle conjugates
US20060246523A1 (en) * 2005-04-28 2006-11-02 Christopher Bieniarz Antibody conjugates
US20060260002A1 (en) * 2003-06-19 2006-11-16 Gil Ronen Nucleotide sequences for regulating gene expression in plant trichomes and constructs and methods utilizing same
US20060257429A1 (en) * 2003-10-23 2006-11-16 Dreier Kimberly J Vaccine for periodontal disease
US20060257865A1 (en) * 2001-10-23 2006-11-16 Simon Mallal Method for identification and development of therapeutic agents
WO2006134602A2 (en) 2005-06-16 2006-12-21 Ramot At Tel Aviv University Ltd. Isolated cells and populations comprising same for the treatment of cns diseases
US20070032421A1 (en) * 2003-12-12 2007-02-08 Efrat Levy Methods and compositions relating to cystatin C
WO2007020638A2 (en) 2005-08-15 2007-02-22 Evogene Ltd. Methods of increasing abiotic stress tolerance and/or biomass in plants and plants generated thereby
WO2007023491A2 (en) 2005-08-24 2007-03-01 Yeda Research And Development Co. Ltd. Universal donor-derived tolerogenic cells for inducing non-syngeneic transplantation tolerance
WO2007031996A1 (en) 2005-09-12 2007-03-22 Rappaport Family Institute For Research In The Medical Sciences Compositions and methods for diagnosing and treating an inflammation
WO2007034487A1 (en) 2005-09-22 2007-03-29 Yissum Research Development Company Of The Hebrew University Of Jerusalem Nucleic acid constructs, pharmaceutical compositions and methods of using same for treating cancer
US20070087437A1 (en) * 2005-10-14 2007-04-19 Jifan Hu Methods for rejuvenating cells in vitro and in vivo
US20070117153A1 (en) * 2005-11-23 2007-05-24 Christopher Bieniarz Molecular conjugate
US7223902B1 (en) 1999-11-19 2007-05-29 Yissum Research Development Company Of The Hebrew University Of Jerusalem Method of producing recombinant Aspergillus niger β-glucosidase and an aroma spreading plant
US20070134739A1 (en) * 2005-12-12 2007-06-14 Gyros Patent Ab Microfluidic assays and microfluidic devices
US20070160546A1 (en) * 2000-09-28 2007-07-12 Tamar Lotan Use of stinging cells/capsules for the delivery of active agents to keratinous substances
US20070184530A1 (en) * 2006-02-03 2007-08-09 Fuad Fares Long-acting veterinary polypeptides and methods of producing and administering same
WO2007091254A1 (en) 2006-02-06 2007-08-16 Rappaport Family Institute For Research In The Medical Sciences Methods and kit for diagnosing t1dm
US20070196369A1 (en) * 2002-02-20 2007-08-23 Hoogenboom Henricus Renerus J MHC-peptide complex binding ligands
US7270810B2 (en) 2000-01-05 2007-09-18 Yeda Research And Development Co. Ltd. Veto cells effective in preventing graft rejection and devoid of graft versus host potential
US20070225242A1 (en) * 2005-06-21 2007-09-27 The Board Of Trustees Of The Leland Stanford Junior University Method and composition for treating and preventing tumor metastasis in vivo
WO2007110869A2 (en) 2006-03-28 2007-10-04 Tel Hashomer Medical Research Infrastructure And Services Ltd. Methods and kits for determining predisposition to warfarin resistance
US20070281883A1 (en) * 2006-06-05 2007-12-06 Hanna Rosenfeld Development of follicle stimulating hormone agonists and antagonists in fish
US20080004234A1 (en) * 2004-07-06 2008-01-03 Segev Laboratories Limited System for delivering therapeutic agents into living cells and cells nuclei
WO2008010228A2 (en) 2006-07-20 2008-01-24 Yeda Research And Development Co. Ltd. Photosyntheticorganisms and compositions and methods of generating same
WO2008026198A2 (en) 2006-08-28 2008-03-06 Yeda Research And Development Co. Ltd. Methods of generating glial and neuronal cells and use of same for the treatment of medical conditions of the cns
US20080082678A1 (en) * 2005-01-16 2008-04-03 Zlango Ltd. Communications Network System and Methods for Using Same
WO2008041183A2 (en) 2006-10-05 2008-04-10 Technion Research & Development Foundation Ltd. Microtubes and methods of producing same
US20080131419A1 (en) * 2004-09-29 2008-06-05 Yissum Research Development Company Of The Hebrew University Of Jerusalem Recombinant Human T2 Rnase and Uses Thereof
WO2008093342A2 (en) 2007-02-01 2008-08-07 Technion Research & Development Foundation Ltd. Albumin fibers and fabrics and methods of generating and using same
WO2008093341A2 (en) 2007-01-31 2008-08-07 Technion Research & Development Foundation Ltd. Electrospun scaffolds and methods of generating and using same
US20080199895A1 (en) * 2006-10-05 2008-08-21 Yeda Research And Development Co. Ltd. Highly purified and stabilized Na,K-ATPase isoforms and methods of producing same
WO2008120216A1 (en) 2007-04-02 2008-10-09 Ramot At Tel Aviv University Ltd. Methods of detecting cancer cells and use of same for diagnosing and monitoring treatment of the disease
WO2008120202A2 (en) 2007-03-29 2008-10-09 Technion Research & Development Foundation Ltd. Antibodies, methods and kits for diagnosing and treating melanoma
US7442781B2 (en) 2001-08-16 2008-10-28 Urifer Ltd. Diagnosis, prevention and treatment of cancer
WO2008132753A2 (en) 2007-05-01 2008-11-06 Tel Hashomer Medical Research Infrastructure And Services Ltd. Methods and kits for detecting fetal cells in the maternal blood
US20090013087A1 (en) * 2005-01-18 2009-01-08 Zlango Ltd. Communications Network System and Methods For Using Same
WO2009010968A2 (en) 2007-07-15 2009-01-22 Yitzchak Hillman Disease treatment via antimicrobial peptides or their inhibitors
US20090053224A1 (en) * 2007-08-02 2009-02-26 Arresto Biosciences Lox and loxl2 inhibitors and uses thereof
US20090068207A1 (en) * 2005-04-15 2009-03-12 Vascular Biogenics Ltd. Compositions Containing Beta 2-Glycoprotein I-Derived Peptides for the Prevention and/or Treatment of Vascular Disease
WO2009034574A2 (en) 2007-09-12 2009-03-19 Yeda Research And Development Co. Ltd. Methods of treating tumors in immune-privileged sites
EP2058275A1 (en) 2003-01-07 2009-05-13 Ramot at Tel-Aviv University Ltd. Peptide nanostructures encapsulating a foreign material and method of manufacturing same
US20090123553A1 (en) * 2002-12-09 2009-05-14 Ramot At Tel Aviv University Ltd. Peptide nanostructures and methods of generating and using the same
US20090126042A1 (en) * 2004-06-14 2009-05-14 Evogene Ltd. Polynucleotides and polypeptides involved in plant fiber development and methods of using same
US20090143321A1 (en) * 2005-07-07 2009-06-04 Avraham Hochberg Nucleic acid agents for downregulating h19 and methods of using same
EP2071021A2 (en) 2007-12-12 2009-06-17 University of South Florida Bone marrow-derived neuronal cells
US20090156471A1 (en) * 2004-07-15 2009-06-18 Ramot At Tel Aviv University Ltd. Use of anti-amyloid agents for treating and typing pathogen infections
WO2009083958A2 (en) 2007-12-27 2009-07-09 Evogene Ltd. Isolated polypeptides, polynucleotides useful for modifying water user efficiency, fertilizer use efficiency, biotic/abiotic stress tolerance, yield and biomass in plants
WO2009104174A2 (en) 2008-02-21 2009-08-27 Technion Research & Development Foundation Ltd . A method of attaching a cell-of-interest to a microtube
US20090253170A1 (en) * 2003-06-19 2009-10-08 Evogene Ltd. Nucleotide sequences for regulating gene expression in plant trichomes and constructs and methods utilizing same
US7605149B1 (en) 1998-07-13 2009-10-20 University Of South Florida Modulation of the phospholipase A2 pathway as a therapeutic
EP2116618A1 (en) 2008-05-09 2009-11-11 Agency for Science, Technology And Research Diagnosis and treatment of Kawasaki disease
US20090293146A1 (en) * 2006-12-20 2009-11-26 Evogene Ltd. Polynucleotides and polypeptides involved in plant fiber development and methods of using same
US7625707B2 (en) 2003-10-02 2009-12-01 Ramot At Tel Aviv University Ltd. Antibacterial agents and methods of identifying and utilizing same
US7655225B2 (en) 2002-01-25 2010-02-02 Gamida Cell, Ltd. Methods of expanding stem and progenitor cells and expanded cell populations obtained thereby
WO2010017544A2 (en) 2008-08-08 2010-02-11 Genisphere, Inc. Long-acting dna dendrimers and methods thereof
WO2010016806A1 (en) 2008-08-08 2010-02-11 Agency For Science, Technology And Research (A*Star) Vhz for diagnosis and treatment of cancers
US20100055033A1 (en) * 2006-04-07 2010-03-04 The Government Of The United States Of America As Represented By The Secretary Antibody compositions and methods for treatment of neoplastic disease
WO2010031006A1 (en) 2008-09-12 2010-03-18 Cryopraxis Criobiologia Ltda. Ischemic tissue cell therapy
US20100068135A1 (en) * 2005-08-08 2010-03-18 Onconon, Llc Antibody compositions, methods for treating neoplastic disease and methods for regulating fertility
WO2010029545A2 (en) 2008-09-11 2010-03-18 Ben Gurion University Of The Negev Research And Development Authority Compositions and methods for treating s. pneumoniae infection
US7687057B2 (en) 1998-01-09 2010-03-30 Yissum Research Development Company Of The Hebrew University Of Jerusalem In vitro micro-organs, and uses related thereto
WO2010035261A2 (en) 2008-09-29 2010-04-01 Ben Gurion University Of The Negev Research And Development Authority Amyloid beta-peptides and methods of use thereof
US20100081177A1 (en) * 2008-09-05 2010-04-01 TransAlgae Ltd Decreasing RUBISCO content of algae and cyanobacteria cultivated in high carbon dioxide
EP2174668A2 (en) 2004-11-14 2010-04-14 Vascular Biogenics Ltd. Promoters exhibiting endothelial cell specificity and methods of using same for regulation of angiogenesis
US20100092386A1 (en) * 2007-04-23 2010-04-15 David Segev System for delivering therapeutic agents into living cells and cells nuclei
US20100105759A1 (en) * 2007-01-16 2010-04-29 Abraham Hochberg H19 silencing nucleic acid agents for treating rheumatoid arthritis
US20100105608A1 (en) * 2002-01-31 2010-04-29 Tel Aviv University Future Technology Development L.P. Peptides and methods using same for diagnosis and treatment of amyloid-associated disease
EP2182052A1 (en) 2002-10-07 2010-05-05 Technion Research and Development Foundation, Ltd. Human foreskin cells suitable for culturing stem cells
WO2010049897A2 (en) 2008-10-30 2010-05-06 Evogene Ltd. Isolated polynucleotides and polypeptides and methods of using same for increasing plant yield, biomass, growth rate, vigor, oil content, abiotic stress tolerance of plants and nitrogen use efficieny
EP2186530A1 (en) 2000-11-17 2010-05-19 Vascular Biogenics Ltd. Promoters exhibiting endothelial cell specificity and methods of using same
WO2010055525A1 (en) 2008-11-17 2010-05-20 Technion Research & Development Foundation Ltd. Method for predicting a patient's responsiveness to anti-folate therapy
WO2010058396A1 (en) 2008-11-19 2010-05-27 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. A cd44vra antibody and diagnostic and therapeutic methods using same
WO2010061383A1 (en) 2008-11-26 2010-06-03 Biodalia Microbiological Technologies Ltd. A method of in-situ enrichment of foods with fructan
WO2010064231A1 (en) 2008-12-02 2010-06-10 Tel Hashomer Medical Research Infrastructure And Services Ltd. Methods of analyzing a-i rna editing and nucleic acid constructs capable of same
WO2010064247A1 (en) 2008-12-03 2010-06-10 Tel Hashomer Medical Research Infrastructure And Services Ltd. Methods and kits for determining predisposition to cancer
WO2010071610A1 (en) 2008-12-19 2010-06-24 Agency For Science, Technology And Research (A*Star) Severe chikungunya biomarkers
WO2010076794A1 (en) 2008-12-31 2010-07-08 Technion Research & Development Foundation Ltd. Method of denitrifying brine and systems capable of same
WO2010076642A1 (en) 2008-12-29 2010-07-08 Tel Hashomer Medical Research, Infrastructure And Services Ltd Peptides and compositions for prevention of cell adhesion and methods of using same
WO2010076756A2 (en) 2008-12-29 2010-07-08 Evogene Ltd. Polynucleotides, polypeptides encoded thereby, and methods of using same for increasing abiotic stress tolerance, biomass and/or yield in plants expressing same
WO2010076788A2 (en) 2008-12-29 2010-07-08 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Methods of predicting responsiveness to interferon treatment and treating hepatitis c infection
US20100196403A1 (en) * 2007-01-29 2010-08-05 Jacob Hochman Antibody conjugates for circumventing multi-drug resistance
WO2010086867A2 (en) 2009-02-02 2010-08-05 Ramot At Tel Aviv University Ltd. Peptides, pharmaceutical compositions comprising same and uses thereof
WO2010086856A2 (en) 2009-02-01 2010-08-05 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Methods of generating tissue using devitalized, acellular scaffold matrices derived from micro-organs
EP2216033A2 (en) 2003-03-06 2010-08-11 Yeda Research and Development Co. Ltd. Methods of treating disease by transplantation of allogeneic or xenogeneic organs or tissues
WO2010089707A1 (en) 2009-02-04 2010-08-12 Yeda Research And Development Co. Ltd. Methods and kits for determining sensitivity or resistance of prostate cancer to radiation therapy
WO2010097793A2 (en) 2009-02-26 2010-09-02 Tel Hashomer Medical Research Infrastructure And Services Ltd. Isolated populations of renal stem cells and methods of isolating and using same
US20100221233A1 (en) * 2003-12-15 2010-09-02 University Of South Florida Compositions and methods for enhancing neuroprotection via administration of stem cells and blood brain barrier permeabilizers
WO2010100595A2 (en) 2009-03-02 2010-09-10 Evogene Ltd. Isolated polynucleotides and polypeptides, and methods of using same for increasing plant yield and/or agricultural characteristics
WO2010103517A1 (en) 2009-03-12 2010-09-16 Rappaport Family Institute For Research In The Medical Sciences Soluble compositions for the treatment of cxcr3-ligand associated diseases
EP2237037A1 (en) 2005-12-12 2010-10-06 Gyros Patent Ab Microfluidic device and use thereof
WO2010113096A1 (en) 2009-03-30 2010-10-07 Tel Hashomer Medical Research Infrastructure And Services Ltd. Methods of predicting clinical course and treating multiple sclerosis
WO2010113146A1 (en) 2009-04-01 2010-10-07 The Medical Research, Infrastructure, And Health Services Fund Of The Tel Aviv Medical Center A method of regulating proliferation and differentiation of keratinocyes
WO2010116375A1 (en) 2009-04-08 2010-10-14 Yeda Research And Development Co. Ltd. Isolated peptides for regulating apoptosis
WO2010137013A1 (en) 2009-05-27 2010-12-02 Ramot At Tel Aviv University Ltd. Crystallized photosystem i units from the pea plant and their use in solid state devices
WO2010137020A1 (en) 2009-05-28 2010-12-02 Yeda Research And Development Co. Ltd. Methods of treating inflammation
WO2010137021A2 (en) 2009-05-27 2010-12-02 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Method of generating connective tissue
WO2010137017A2 (en) 2009-05-27 2010-12-02 Yeda Research And Development Co. Ltd. Proteasome inhibitors and uses thereof
US7855075B2 (en) 1998-02-17 2010-12-21 Gamida Cell Ltd. Methods of controlling proliferation and differentiation of stem and progenitor cells
WO2010150259A1 (en) 2009-06-24 2010-12-29 Fund For Medical Research Development Of Infrastructure And Health Services -Rambam Medical Center Methods and kits for isolating placental derived microparticles and use of same for diagnosis of fetal disorders
WO2011004361A2 (en) 2009-07-09 2011-01-13 Prolor Biotech Inc. Long-acting coagulation factors and methods of producing same
WO2011004379A1 (en) 2009-07-10 2011-01-13 Tel Hashomer Medical Research Infrastructure And Services Ltd. Compositions and methods for treating cancer
WO2011010309A1 (en) 2009-07-21 2011-01-27 Tel Hashomer Medical Research Infrastructure And Services Ltd. A method of diagnosing cancer
US20110020357A1 (en) * 2008-04-09 2011-01-27 Technion Research & Development Foundation Ltd. Anti human immunodeficiency antibodies and uses thereof
EP2279726A2 (en) 2005-05-26 2011-02-02 Biorest Ltd. Compositions and methods using same for delivering agents into a target organ protected by a blood barrier
WO2011013130A2 (en) 2009-07-31 2011-02-03 Ramot At Tel-Aviv University Ltd. Cell-targeting nanoparticles comprising polynucleotide agents and uses thereof
US20110033473A1 (en) * 2008-04-09 2011-02-10 Yoram Reiter Anti influenza antibodies and uses thereof
WO2011021194A2 (en) 2009-08-17 2011-02-24 Technion Research & Development Foundation Ltd. Pericyte progenitor cells and methods of generating and using same
WO2011021171A1 (en) 2009-08-21 2011-02-24 Beeologics, Llc Preventing and curing beneficial insect diseases via plant transcribed molecules
EP2289567A2 (en) 2003-12-22 2011-03-02 Regentis Biomaterials Ltd. Matrix comprising naturally-occurring crosslinked protein backbone
US20110052501A1 (en) * 2008-01-31 2011-03-03 Liat Dassa Polypeptides and polynucleotides, and uses thereof as a drug target for producing drugs and biologics
WO2011024172A2 (en) 2009-08-27 2011-03-03 Technion Research & Development Foundation Ltd. Liposomal compositions and uses of same
EP2295980A1 (en) 2002-10-30 2011-03-16 Yissum Research Development Company, of The Hebrew University of Jerusalem Molecules and methods using same for measuring non-transferrin bound iron
WO2011030332A2 (en) 2009-09-08 2011-03-17 Yeda Research And Development Co. Ltd. Methods for hematopoietic precursor mobilization
WO2011030336A1 (en) 2009-09-08 2011-03-17 Ramot At Tel-Aviv University Ltd. Methods of diagnosing amyotrophic lateral sclerosis (als)
WO2011030329A1 (en) 2009-09-10 2011-03-17 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Method of treating tumors
WO2011033506A2 (en) 2009-09-17 2011-03-24 Yeda Research And Development Co. Ltd. Isolated pon1 polypeptides, polynucleotides encoding same and uses thereof in treating or preventing organophosphate exposure associated damage
WO2011033511A1 (en) 2009-09-17 2011-03-24 Ramot At Tel-Aviv University Ltd. Peptides for the treatment of oxidative stress related disorders
US20110081706A1 (en) * 2009-10-02 2011-04-07 TransAlgae Ltd Method and system for efficient harvesting of microalgae and cyanobacteria
EP2308994A1 (en) 2001-03-23 2011-04-13 Yeda Research And Development Co., Ltd. Methods for determining a risk to develop cancer
US20110091454A1 (en) * 2004-01-27 2011-04-21 Alex Diber Methods and systems for annotating biomolecular sequences
WO2011046570A1 (en) 2009-10-16 2011-04-21 The University Of Medicine And Dentistry Of New Jersey Method for treating chronic nerve tissue injury using a cell therapy strategy
WO2011045796A1 (en) 2009-10-14 2011-04-21 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Compositions for controlling varroa mites in bees
WO2011048600A1 (en) 2009-10-21 2011-04-28 Danziger Innovations Ltd. Generating genotypic variations in plant genomes by gamete infection
EP2316950A1 (en) 2000-03-27 2011-05-04 Technion Research and Development Foundation, Ltd. Single chain class I major histo-compatibility complexes, constructs encoding same and methods of generating same
EP2316441A1 (en) 2005-02-17 2011-05-04 Hadasit Medical Research Services And Development Bisphosphonates for treating endometriosis
EP2319857A2 (en) 2003-03-04 2011-05-11 Yeda Research And Development Co., Ltd. Pon polypeptides, polynucleotides encoding same and compositions and methods utilizing same
WO2011055366A1 (en) 2009-11-08 2011-05-12 Medical Research & Development Fund For Health Services Bnai Zion Medical Center, The State Of Israel Mo-1 conditional knock-out non-human animal and uses thereof
WO2011058555A1 (en) 2009-11-12 2011-05-19 Yeda Research And Development Co. Ltd. A method of editing dna in a cell and constructs capable of same
WO2011058557A1 (en) 2009-11-12 2011-05-19 Ramot At Tel-Aviv University Ltd. Compositions comprising pedf and uses of same in the treatment and prevention of ovary-related syndromes
WO2011061736A1 (en) 2009-11-17 2011-05-26 Protalix Ltd. Alkaline alpha galactosidase for the treatment of fabry disease
WO2011064773A1 (en) 2009-11-24 2011-06-03 Collplant Ltd. Method of generating collagen fibers
WO2011064669A2 (en) 2009-11-30 2011-06-03 Pluristem Ltd. Adherent cells from placenta and use of same in disease treatment
EP2330132A1 (en) 2003-04-04 2011-06-08 Yeda Research and Development Co. Ltd. Antibodies and pharmaceutical compositions containing same useful for inhibiting activity of metalloproteins
WO2011067745A2 (en) 2009-12-06 2011-06-09 Rosetta Green Ltd. Compositions and methods for enhancing plants resistance to abiotic stress
WO2011072091A1 (en) 2009-12-09 2011-06-16 Quark Pharmaceuticals, Inc. Methods and compositions for treating diseases, disorders or injury of the cns
US20110150874A1 (en) * 2006-05-19 2011-06-23 Teva Pharmaceutical Industries Ltd. Fusion proteins, uses thereof and processes for producing same
US20110147993A1 (en) * 2008-04-10 2011-06-23 Objet Geometries Ltd. System and method for three dimensional model printing
EP2338896A2 (en) 2002-12-12 2011-06-29 R.B.T. (Rakuto Bio Technologies) Ltd. Use of lignin peroxidase in skin and hair lightening
US7973156B2 (en) 1997-08-21 2011-07-05 Quark Pharmaceuticals Inc. Hypoxia-regulated genes
WO2011080674A2 (en) 2009-12-28 2011-07-07 Evogene Ltd. Isolated polynucleotides and polypeptides and methods of using same for increasing plant yield, biomass, growth rate, vigor, oil content, abiotic stress tolerance of plants and nitrogen use efficiency
WO2011080740A1 (en) 2009-12-29 2011-07-07 Gamida-Cell Ltd. Methods for enhancing natural killer cell proliferation and activity
WO2011086509A1 (en) 2010-01-12 2011-07-21 Vascular Biogenics Ltd. Methods of producing adenovirus vectors and viral preparations generated thereby
WO2011092700A1 (en) 2010-01-27 2011-08-04 Yeda Research And Development Co. Ltd. Antibodies that inhibit metalloproteins
US8000900B2 (en) 2004-09-21 2011-08-16 Microsoft Corporation Association-based predictions of pathogen characteristics
WO2011099006A2 (en) 2010-02-11 2011-08-18 Yeda Research And Development Co. Ltd. Enzymatic systems for carbon fixation and methods of generating same
EP2359854A1 (en) 2000-08-08 2011-08-24 Technion Research and Development Foundation, Ltd. Pharmaceutical compositions and methods useful for modulating angiogenesis
US20110207144A1 (en) * 2009-08-21 2011-08-25 Derek Marshall In vitro screening assays
US8007847B2 (en) 2004-01-13 2011-08-30 Eytan Biderman Feeding formula appliance
WO2011104708A2 (en) 2010-02-24 2011-09-01 Ben Gurion University Of The Negev Research And Development Authority Methods for inhibiting necrosis
WO2011107939A1 (en) 2010-03-01 2011-09-09 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Methods of predicting efficacy of an anti-vegfa treatment for solid tumors
WO2011107994A1 (en) 2010-03-04 2011-09-09 Yeda Research And Development Co. Ltd. Methods of measuring protein stability
EP2365087A2 (en) 2003-05-22 2011-09-14 Evogene Ltd. Methods of increasing abiotic stress tolerance and/or biomass in plants and plants generated thereby
WO2011111034A1 (en) 2010-03-08 2011-09-15 Yeda Research And Development Co. Ltd. Recombinant protein production in heterologous systems
WO2011111050A2 (en) 2010-03-11 2011-09-15 Jacob Edrei Methods of generating hydrogen
EP2366775A1 (en) 2006-03-23 2011-09-21 Pluristem Ltd. Methods for cell expansion and uses of cells and conditioned media produced thereby for therapy
WO2011125015A2 (en) 2010-04-05 2011-10-13 Bar-Ilan University Protease-activatable pore-forming polypeptides
WO2011128897A1 (en) 2010-04-12 2011-10-20 Technion Research & Development Foundation Ltd. Populations of pancreatic progenitor cells and methods of isolating and using same
WO2011132182A1 (en) 2010-04-18 2011-10-27 Yeda Research And Development Co. Ltd. MOLECULES AND METHODS OF USING SAME FOR TREATING ErbB/ErbB LIGANDS ASSOCIATED DISEASES
WO2011135527A2 (en) 2010-04-28 2011-11-03 Evogene Ltd. Isolated polynucleotides and polypeptides, and methods of using same for increasing plant yield and/or agricultural characteristics
WO2011138785A2 (en) 2010-05-05 2011-11-10 Rappaport Family Institute For Research In The Medical Sciences Use of ccl1 in therapy
WO2011138776A2 (en) 2010-05-06 2011-11-10 Hervana Ltd. Biologic female contraceptives
WO2011138778A2 (en) 2010-05-04 2011-11-10 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Methods of identifying inhibitors of polypeptides-of-interest
WO2011141914A1 (en) 2010-05-13 2011-11-17 Tel Hashomer Medical Research Infrastructure And Services Ltd. Isolated populations of adult renal cells and methods of isolating and using same
EP2390312A1 (en) 2005-11-29 2011-11-30 Gamida Cell Ltd. Methods of improving stem cell homing and engraftment
EP2390664A1 (en) 2010-05-25 2011-11-30 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Method for electrochemical detection of binding reactions
WO2011150186A1 (en) * 2010-05-26 2011-12-01 The Board Of Trustees Of The University Of Illinois Personal glucose meters for detection and quantification of a broad range of analytes
WO2011151833A1 (en) 2010-06-03 2011-12-08 Ramot At Tel-Aviv University Ltd. Methods of treating diabetes and compositions capable of same
WO2011154940A1 (en) 2010-06-07 2011-12-15 Osnat Ashur-Fabian Methods and kits for diagnosing conditions related to hypoxia
US8080417B2 (en) 2004-09-16 2011-12-20 Gamida-Cell Ltd. Methods of ex vivo hematopoietic stem cell expansion by co-culture with mesenchymal cells
WO2011158242A2 (en) 2010-06-16 2011-12-22 Futuragene Israel Ltd. Pest -resistant plants containing a combination of a spider toxin and a chitinase
WO2011158243A2 (en) 2010-06-16 2011-12-22 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Method of diagnosing and treating cancer
US8088160B2 (en) 2000-07-20 2012-01-03 Multi-Gene Vascular Systems Ltd. (“MGVS”) Drug-eluting intravascular prostheses and methods of use
WO2012007951A1 (en) 2010-07-15 2012-01-19 Technion Research & Development Foundation Ltd. Isolated high affinity entities with t-cell receptor like specificity towards native complexes of mhc class ii and glutamic acid decarboxylase (gad) autoantigenic peptides
WO2012007919A2 (en) 2010-07-15 2012-01-19 Technion Research & Development Foundation Ltd. Nucleic acid construct for increasing abiotic stress tolerance in plants
WO2012007945A2 (en) 2010-07-12 2012-01-19 The State Of Israel, Ministry Of Agriculture & Rural Development, Agricultural Research Organization, (A.R.O.), Volcani Center Isolated polynucleotides and methods and plants using same for regulating plant acidity
WO2012007950A2 (en) 2010-07-15 2012-01-19 Technion Research & Development Foundation Ltd. Isolated high affinity entities with t-cell receptor like specificity towards native complexes of mhc class ii and diabetes-associated autoantigenic peptides
WO2012011113A2 (en) 2010-07-22 2012-01-26 Shai Yarkoni Regulatory immune cells with enhanced targeted cell death effect
WO2012014207A2 (en) 2010-07-27 2012-02-02 Technion Research & Development Foundation Ltd. Method for generating induced pluripotent stem cells from keratinocytes derived from plucked hair follicles
WO2012014205A1 (en) 2010-07-27 2012-02-02 Technion Research & Development Foundation Ltd. Isolated mesenchymal progenitor cells and extracellular matrix produced thereby
WO2012014208A2 (en) 2010-07-27 2012-02-02 Yeda Research And Development Co. Ltd. Methods and systems for assessing clonality of cell cultures
WO2012017439A2 (en) 2010-08-04 2012-02-09 Ramot At Tel-Aviv University Ltd. Methods of treating autoimmune diseases of the central nervous system (cns) and neurodegenerative diseases
WO2012025925A1 (en) 2010-08-24 2012-03-01 Rappaport Family Institute For Research In The Medical Sciences Methods of improving transplantation using sdf-1alpha
WO2012025914A1 (en) 2010-08-22 2012-03-01 Ramot At Tel-Aviv University Ltd. Induced pluripotent stem cells derived from human pancreatic beta cells
EP2425841A1 (en) 2000-11-24 2012-03-07 Vascular Biogenics Ltd. Methods Employing and Compositions Containing Defined Oxidized Phospholipids for Prevention and Treatment of Atherosclerosis
WO2012032520A1 (en) 2010-09-07 2012-03-15 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Readthrough acetylcholinesterase (ache-r) for treating or preventing parkinson's disease
WO2012032510A1 (en) 2010-09-07 2012-03-15 Yeda Research And Development Co. Ltd. Primers for amplifying dna and methods of selecting same
WO2012032521A2 (en) 2010-09-07 2012-03-15 Technion Research & Development Foundation Ltd. Novel methods and culture media for culturing pluripotent stem cells
WO2012032519A2 (en) 2010-09-07 2012-03-15 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Methods of diagnosing parkinson's disease
WO2012032525A2 (en) 2010-09-08 2012-03-15 Yeda Research And Development Co. Ltd. An immunosuppressive drug combination for a stable and long term engraftment
WO2012032526A2 (en) 2010-09-08 2012-03-15 Yeda Research And Development Co. Ltd. Use of anti third party central memory t cells for anti-leukemia/lymphoma treatment
WO2012035539A1 (en) 2010-09-15 2012-03-22 Ramot At Tel-Aviv University Ltd. Methods of expanding and redifferentiating islet beta cells
WO2012038956A1 (en) 2010-09-20 2012-03-29 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Method of treating neurodegenerative diseases
EP2441840A1 (en) 2005-07-18 2012-04-18 Protalix Ltd. Mucosal or enteral administration of biologically active macromolecules
WO2012052872A2 (en) 2010-10-17 2012-04-26 Yeda Research And Development Co. Ltd. Methods and compositions for the treatment of insulin-associated medical conditions
WO2012052878A1 (en) 2010-10-19 2012-04-26 Vascular Biogenics Ltd. Isolated polynucleotides and nucleic acid constructs for directing expression of a gene-of-interest in cells
WO2012056455A1 (en) 2010-10-28 2012-05-03 Yeda Research And Development Co. Ltd. Methods of generating antibodies to metalloenzymes
WO2012056452A2 (en) 2010-10-27 2012-05-03 Nanocyte (Israel) Ltd. Pharmaceutical compositions and delivery devices comprising stinging cells or capsules
WO2012059922A2 (en) 2010-11-03 2012-05-10 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Transgenic plants with improved saccharification yields and methods of generating same
WO2012059925A2 (en) 2010-11-04 2012-05-10 Ben-Gurion University Of The Negev Research And Development Authority Acyl-coa: diacylglycerol acyltransferase 1-like gene (ptdgat1) and uses thereof
WO2012066495A2 (en) 2010-11-17 2012-05-24 Ben Gurion University Of The Negev Research And Development Authority T-cell therapy to neurodegenerative diseases
EP2457999A2 (en) 2002-12-16 2012-05-30 Technion Research & Development Foundation Ltd. Culture medium for pluropotent stem cells
WO2012073238A1 (en) 2010-12-02 2012-06-07 Technion Research & Development Foundation Ltd. Methods of generating corneal cells and cell populations comprising same
EP2463382A1 (en) 2010-12-07 2012-06-13 Enterologics, Inc. Method for identifying E. Coli M-17
WO2012081029A1 (en) 2010-12-15 2012-06-21 Kadimastem Ltd. Insulin producing cells derived from pluripotent stem cells
WO2012090205A2 (en) 2010-12-28 2012-07-05 Kamedis Ltd. Plant extracts for the treatment and prevention of infections
WO2012098537A1 (en) 2011-01-20 2012-07-26 Protalix Ltd. Nucleic acid construct for expression of alpha-galactosidase in plants and plant cells
WO2012104851A1 (en) 2011-01-31 2012-08-09 Yeda Research And Development Co. Ltd. Methods of diagnosing disease using overlap extension pcr
EP2487182A2 (en) 2005-07-07 2012-08-15 FULCRUM SP Ltd. SP1 polypeptides, modified SP1 polypeptides and uses thereof
US8252588B2 (en) 2003-04-08 2012-08-28 Yeda Research And Development Co. Ltd. Stem cells having increased sensitivity to SDF-1 and methods of generating and using same
WO2012114339A1 (en) 2011-02-23 2012-08-30 Rappaport Family Institute For Research In The Medical Sciences High affinity molecules capable of binding a type a plexin receptor and uses of same
WO2012117406A2 (en) 2011-03-02 2012-09-07 Futuragene Israel Ltd. Bacterial resistant transgenic plants
WO2012117373A1 (en) 2011-03-03 2012-09-07 Ramot At Tel-Aviv University Ltd. Genetically modified muscle cells which express neurotrophic factors
WO2012120518A1 (en) 2011-03-08 2012-09-13 Ramot At Tel-Aviv University Ltd. Compositions and methods for diagnosing and treating phenylketonuria (pku)
WO2012120500A2 (en) 2011-03-06 2012-09-13 Merck Serono S.A. Low fucose cell lines and uses thereof
EP2500428A2 (en) 2007-07-11 2012-09-19 Yeda Research and Development Co. Ltd. Nucleic acid construct systems capable of diagnosing or treating a cell state
WO2012123949A1 (en) 2011-03-17 2012-09-20 Ramot At Tel-Aviv University Ltd. Bi- and monospecific, asymmetric antibodies and methods of generating the same
WO2012123938A1 (en) 2011-03-17 2012-09-20 Tel Hashomer Medical Research Infrastructure And Services Ltd. Quinolone analogs for treating autoimmune diseases
WO2012127475A1 (en) 2011-03-24 2012-09-27 Neurim Pharmaceuticals (1991) Ltd. Neuroprotective peptides
WO2012127320A1 (en) 2011-03-22 2012-09-27 Pluristem Ltd. Methods for treating radiation or chemical injury
WO2012131680A2 (en) 2011-03-28 2012-10-04 Yeda Research And Development Co. Ltd. Compositions and methods for treating inflammation
WO2012137207A1 (en) 2011-04-06 2012-10-11 Ramot At Tel-Aviv University Ltd. Methods of monitoring and analyzing metabolic activity profiles diagnostic and therapeutic uses of same
WO2012137202A1 (en) 2011-04-05 2012-10-11 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Composition comprising an iron indicator attached to a microparticle and uses of same for quantifying non-transferrin bound iron (ntbi) and cellular labile iron (lci)
WO2012140519A2 (en) 2011-04-15 2012-10-18 Pluristem Ltd. Methods and systems for harvesting cells
WO2012150600A2 (en) 2011-05-04 2012-11-08 Ramot At Tel-Aviv University Ltd. Regulation of amyloid beta molecular composition for the treatment of alzheimer's disease
WO2012153336A2 (en) 2011-05-12 2012-11-15 Rakuto Bio Technologies Ltd. Methods and device for lightening skin complexion
WO2012153333A1 (en) 2011-05-09 2012-11-15 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Regeneration and repair of mesenchymal tissue using amelogenin
WO2012156976A1 (en) 2011-05-16 2012-11-22 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Methods of producing artemisinin in non-host plants and vectors for use in same
EP2526952A1 (en) 2003-07-15 2012-11-28 Bar-Ilan University Methods and pharmaceutical compositions for healing wounds
EP2527441A2 (en) 2007-07-15 2012-11-28 Technion Research & Development Foundation Compositions and methods for treating tumors, fibrosis, and pulmonary alveolar proteinosis
WO2012160526A2 (en) 2011-05-23 2012-11-29 Ofir Menashe Formulations of microorganism comprising particles and uses of same
US8323636B2 (en) 2006-02-03 2012-12-04 Prolor Biotech Ltd. Long-acting interferons and derivatives thereof and methods thereof
EP2529754A1 (en) 2007-05-03 2012-12-05 Agency For Science, Technology And Research (A*star) Antibodies binding to an intracellular PRL-1 or PRL-3 polypeptide
WO2012164380A2 (en) 2011-05-31 2012-12-06 Hutchison Biofilm Medical Solutions Limited Dispersion and detachment of cell aggregates
WO2012164565A1 (en) 2011-06-01 2012-12-06 Yeda Research And Development Co. Ltd. Compositions and methods for downregulating prokaryotic genes
WO2012172555A1 (en) 2011-06-14 2012-12-20 Yeda Research And Development Co. Ltd. Combination therapy to prevent dcis formation and progression to breast cancer
WO2012176203A1 (en) 2011-06-23 2012-12-27 Kaiima Bio Agritech Ltd. Common wheat, plants or parts thereof having partially or fully multiplied genome, hybrids and products thereof and methods of generating and using same
US8352031B2 (en) 2004-03-10 2013-01-08 Impulse Dynamics Nv Protein activity modification
WO2013011507A1 (en) 2011-07-20 2013-01-24 Kaiima Bio Agritech Ltd. Maize plants having a partially or fully multiplied genome and uses thereof
EP2550982A1 (en) 2011-07-27 2013-01-30 Technion Research & Development Foundation Ltd. Devices for surgical applications
WO2013018060A2 (en) 2011-08-04 2013-02-07 Yeda Research And Development Co. Ltd. Micro-rnas and compositions comprising same for the treatment and diagnosis of serotonin-, adrenalin-, noradrenalin-, glutamate-, and corticotropin-releasing hormone- associated medical conditions
WO2013018098A2 (en) 2011-08-02 2013-02-07 Prolor Biotech Ltd. Long-acting growth hormone and methods of producing same
US8375327B2 (en) 2005-01-16 2013-02-12 Zlango Ltd. Iconic communication
WO2013021389A2 (en) 2011-08-09 2013-02-14 Yeda Research And Development Co.Ltd. Downregulation of mir-7 for promotion of beta cell differentiation and insulin production
WO2013024481A1 (en) 2011-08-14 2013-02-21 Kaiima Bio Agritech Ltd. Durum wheat plants having a partially or fully multiplied genome and uses thereof
EP2561889A2 (en) 2002-08-01 2013-02-27 Yeda Research and Development Co. Ltd. Method and composition for protecting neuronal tissue from damage induced by elevated glutamate levels
US8388954B2 (en) 2003-04-09 2013-03-05 Laboratoire Francais Du Fractionnement Et Des Biotechnologies Stabilising formulation for immunoglobulin G compositions in liquid form and in lyophilised form
WO2013035099A1 (en) 2011-09-08 2013-03-14 Yeda Research And Development Co. Ltd. Anti third party central memory t cells, methods of producing same and use of same in transplantation and disease treatment
WO2013035070A1 (en) 2011-09-07 2013-03-14 Yeda Research And Development Co. Ltd. Olfactory signature and odorant mixture having the same
WO2013035071A1 (en) 2011-09-08 2013-03-14 Yeda Research And Development Co. Ltd. Novel risk biomarkers for lung cancer
US8415318B2 (en) 2001-10-19 2013-04-09 Vascular Biogenics Ltd. Polynucleotide constructs, pharmaceutical compositions and methods for targeted downregulation of angiogenesis and anticancer therapy
EP2581445A1 (en) 2007-08-15 2013-04-17 Yeda Research And Development Co. Ltd. Regulators of MMP-9 and uses thereof
WO2013054331A1 (en) 2011-10-11 2013-04-18 Tel Hashomer Medical Research Infrastructure And Services Ltd. Antibodies to carcinoembryonic antigen-related cell adhesion molecule (ceacam)
US8426166B2 (en) 2006-02-03 2013-04-23 Prolor Biotech Inc. Long-acting polypeptides and methods of producing same
WO2013056377A1 (en) 2011-10-21 2013-04-25 Augurex Life Sciences Corporation Antigens derived from citrullinated 14-3-3 and uses thereof in the diagnosis of rheumatoid arthritis
WO2013061328A2 (en) 2011-10-27 2013-05-02 Yeda Research And Development Co. Ltd. Method of treating cancer
WO2013067076A2 (en) 2011-11-03 2013-05-10 Quark Pharmaceuticals, Inc. Methods and compositions for neuroprotection
EP2591789A2 (en) 2007-09-19 2013-05-15 Pluristem Ltd. Adherent cells from adipose or placenta tissues and use thereof in therapy
WO2013070821A1 (en) 2011-11-08 2013-05-16 Quark Pharmaceuticals, Inc. Methods and compositions for treating diseases, disorders or injury of the nervous system
WO2013076730A1 (en) 2011-11-27 2013-05-30 Yeda Research And Development Co. Ltd. Methods of regulating angiogenesis and compositions capable of same
WO2013076729A1 (en) 2011-11-23 2013-05-30 Danziger Dan Flower Farm Otomeria plants
EP2599790A1 (en) 2007-11-26 2013-06-05 Yissum Research Development Company of The Hebrew University of Jerusalem Compositions comprising fibrous polypeptides and polysachharides
WO2013084190A1 (en) 2011-12-08 2013-06-13 Yeda Research And Development Co. Ltd. Mammalian fetal pulmonary cells and therapeutic use of same
WO2013093921A1 (en) 2011-12-20 2013-06-27 Collplant Ltd. Collagen coated synthetic polymer fibers
WO2013093920A2 (en) 2011-12-22 2013-06-27 Yeda Research And Development Co. Ltd. A combination therapy for a stable and long term engraftment
US8478535B2 (en) 2004-10-29 2013-07-02 Microsoft Corporation Systems and methods that utilize machine learning algorithms to facilitate assembly of aids vaccine cocktails
WO2013098813A1 (en) 2012-01-01 2013-07-04 Qbi Enterprises Ltd. Endo180-targeted particles for selective delivery of therapeutic and diagnostic agents
WO2013098820A1 (en) 2011-12-28 2013-07-04 Kaiima Bio Agritech Ltd. Cultivated sorghum plant having a partially or fully multiplied genome and uses of same
EP2620493A1 (en) 2008-05-28 2013-07-31 Ramot at Tel Aviv University Ltd. Mesenchymal stem cells for the treatment of CNS diseases
WO2013114371A1 (en) 2012-02-01 2013-08-08 Protalix Ltd. Dry powder formulations of dnase i
WO2013114363A2 (en) 2012-01-30 2013-08-08 Yeda Research And Development Co.Ltd. Antimicrobial agents
US8513488B2 (en) 2007-04-09 2013-08-20 Evogene Ltd. Polynucleotides, polypeptides and methods for increasing oil content, growth rate and biomass of plants
US8512990B2 (en) 2009-08-21 2013-08-20 Gilead Biologics, Inc. Catalytic domains from lysyl oxidase and LOXL2
WO2013121426A1 (en) 2012-02-13 2013-08-22 Gamida-Cell Ltd. Culturing of mesenchymal stem cells
WO2013121416A1 (en) 2012-02-14 2013-08-22 Prolor Biotech Inc. Long-acting coagulation factors and methods of producing same
WO2013121405A1 (en) 2012-02-19 2013-08-22 Protalix Ltd. Oral unit dosage forms and uses of same for the treatment of gaucher disease
WO2013124816A2 (en) 2012-02-22 2013-08-29 Brainstem Biotec Ltd. Generation of neural stem cells and motor neurons
WO2013124817A2 (en) 2012-02-22 2013-08-29 Brainstem Biotec Ltd. MicroRNAS FOR THE GENERATION OF ASTROCYTES
EP2633854A1 (en) 2008-12-05 2013-09-04 Yeda Research And Development Co. Ltd. miRNA-9 or miRNA-9* for use in treating MND
WO2013128454A1 (en) 2012-03-01 2013-09-06 The State Of Israel, Ministry Of Agriculture & Rural Development, Agricultural Research Organization, (A.R.O.), Volcani Center Male sterile garlic plants, hybrid offspring of same and methods of generating and using same
WO2013132495A1 (en) 2012-03-07 2013-09-12 Yeda Research And Development Co. Ltd. Compositions for inhibition of quiescin sulfhydryl oxidase (qsox1) and uses of same
WO2013136335A1 (en) 2012-03-15 2013-09-19 Yeda Research And Development Co. Ltd. Isolated pon1 polypeptides, polynucleotides encoding same and uses thereof in treating or preventing organophosphate exposure associated damage
EP2641606A1 (en) 2008-05-27 2013-09-25 Pluristem Ltd. Methods of treating inflammatory colon diseases
WO2013140389A1 (en) 2012-03-22 2013-09-26 Ramot At Tel-Aviv University Ltd. Plif multimeric peptides and uses thereof
WO2013153553A2 (en) 2012-04-13 2013-10-17 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Compositions for controlling varroa mites in bees
WO2013160895A1 (en) 2012-04-24 2013-10-31 Biokine Therapeutics Ltd. Peptides and use thereof in the treatment of large cell lung cancer
WO2013168164A1 (en) 2012-05-09 2013-11-14 Yeda Research And Development Co. Ltd. Variants of tace pro-domain as tnf-a inhibitor and their medical use
WO2013175480A1 (en) 2012-05-24 2013-11-28 A.B. Seeds Ltd. Compositions and methods for silencing gene expression
WO2013174003A1 (en) 2012-05-24 2013-11-28 Mountgate Group Limited Compositions and methods related to prevention and treatment of rabies infection
WO2013183052A1 (en) 2012-06-04 2013-12-12 Prolor Biotech Inc. Pegylated oxm variants
WO2013183048A1 (en) 2012-06-03 2013-12-12 Ben-Gurion University Of The Negev Research And Development Authority Functionalized titanium binding peptides and implants coated with same
WO2014006621A1 (en) 2012-07-03 2014-01-09 Nanospun Technologies Ltd. Methods and devices for adsorption and biodegradation of petroleum
WO2014020599A1 (en) 2012-07-29 2014-02-06 Yeda Research And Development Co. Ltd. Use of the reductive glycine pathway for generating formatotrophic and autotrophic microorganisms
WO2014020608A1 (en) 2012-07-31 2014-02-06 Yeda Research And Development Co. Ltd. Methods of diagnosing and treating motor neuron diseases
WO2014024183A1 (en) 2012-08-06 2014-02-13 Brainstorm Cell Therapeutics Ltd. Methods of generating mesenchymal stem cells which secrete neurotrophic factors
WO2014033723A1 (en) 2012-09-03 2014-03-06 A.B. Seeds Ltd. Method of improving abiotic stress tolerance of plants and plants generated thereby
WO2014041544A1 (en) 2012-09-12 2014-03-20 Ramot At Tel-Aviv University Ltd. Immunoparticles and methods of generating and using same
US8680246B2 (en) 2010-02-04 2014-03-25 Gilead Biologics, Inc. Antibodies that bind to lysyl oxidase-like 2 (LOXL2)
US8686227B2 (en) 2007-07-24 2014-04-01 Evogene Ltd. Polynucleotides, polypeptides encoded thereby, and methods of using same for increasing abiotic stress tolerance and/or biomass and/or yield in plants expressing same
EP2716654A1 (en) 2005-10-24 2014-04-09 Evogene Ltd. Isolated polypeptides, polynucleotides encoding same, transgenic plants expressing same and methods of using same
WO2014057490A1 (en) 2012-10-09 2014-04-17 Ramot At Tel-Aviv University Ltd. Methods and kits for predicting prognosis of cancer using soluble mortalin in blood
WO2014064682A1 (en) 2012-10-24 2014-05-01 Yeda Research And Development Co. Ltd. Combinations of epidermal growth factor receptor targeting antibodies for treating cancer
WO2014068553A1 (en) 2012-10-29 2014-05-08 Yeda Research And Development Co. Ltd. Aptamers, multimeric aptamers and uses thereof
WO2014083567A2 (en) 2012-11-29 2014-06-05 Yeda Research And Development Co. Ltd. Methods of preventing tumor metastasis, treating and prognosing cancer and identifying agents which are putative metastasis inhibitors
US8759292B2 (en) 2006-02-03 2014-06-24 Prolor Biotech, Llc Long-acting coagulation factors and methods of producing same
US8775526B2 (en) 2006-01-16 2014-07-08 Zlango Ltd. Iconic communication
WO2014106837A2 (en) 2013-01-01 2014-07-10 A. B. Seeds Ltd. ISOLATED dsRNA MOLECULES AND METHODS OF USING SAME FOR SILENCING TARGET MOLECULES OF INTEREST
WO2014108854A1 (en) 2013-01-09 2014-07-17 Fusimab Ltd. Monospecific anti-hgf and anti-ang2 antibodies and bispecific anti-hgf/anti-ang2 antibodies
WO2014108850A2 (en) 2013-01-09 2014-07-17 Yeda Research And Development Co. Ltd. High throughput transcriptome analysis
WO2014111936A1 (en) 2013-01-17 2014-07-24 Novellusdx Ltd. Methods and systems for identifying patient specific driver mutations
WO2014118785A1 (en) 2013-02-04 2014-08-07 Ramot At Tel-Aviv University Ltd. Generation of cytotoxic tumor specific cell lines and uses thereof
WO2014136113A1 (en) 2013-03-06 2014-09-12 Protalix Ltd. Chimeric polypeptides, polynucleotides encoding same, cells expressing same and methods of producing same
WO2014136117A1 (en) 2013-03-06 2014-09-12 Protalix Ltd. USE OF PLANT CELLS EXPRESSING A TNFalpha POLYPEPTIDE INHIBITOR IN THERAPY
EP2781223A1 (en) 2007-10-19 2014-09-24 Rappaport Family Institute for Research in the Medical Sciences Compositions comprising semaphorins for the treatment of angiogenesis related diseases
WO2014147622A1 (en) 2013-03-21 2014-09-25 Collplant Ltd. Compositions comprising collagen and prp for tissue regeneration
US8846393B2 (en) 2005-11-29 2014-09-30 Gamida-Cell Ltd. Methods of improving stem cell homing and engraftment
US8847008B2 (en) 2008-05-22 2014-09-30 Evogene Ltd. Isolated polynucleotides and polypeptides and methods of using same for increasing plant utility
WO2014155376A1 (en) 2013-03-24 2014-10-02 Biokine Therapeutics Ltd. Methods of treating myeloid leukemia
EP2789626A2 (en) 2008-09-24 2014-10-15 Tel Hashomer Medical Research Infrastructure and Services Ltd. Peptides and compositions for prevention of cell adhesion and methods of using same
US8865158B2 (en) 2012-05-22 2014-10-21 Ramot At Tel-Aviv University Ltd. Bacteriophages for reducing toxicity of bacteria
WO2014174520A1 (en) 2013-04-25 2014-10-30 Yeda Research And Development Co. Ltd. Use of inhibitory peptides for the treatment of inflammatory diseases
WO2014174511A1 (en) 2013-04-21 2014-10-30 Yeda Research And Development Co. Ltd. Agents for downregulation of the activity and/or amount of bcl-xl and/or bcl-w
WO2014174470A1 (en) 2013-04-23 2014-10-30 Yeda Research And Development Co. Ltd. Isolated naive pluripotent stem cells and methods of generating same
WO2014188423A1 (en) 2013-05-21 2014-11-27 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Treatment of mast cell related pathologies
WO2014191995A2 (en) 2013-05-27 2014-12-04 Rakuto Bio Technologies Ltd. Enzymatic system-containing cosmetic compositions
EP2816117A2 (en) 2004-09-29 2014-12-24 Collplant Ltd. Collagen producing plants and methods of generating and using same
WO2014207744A1 (en) 2013-06-24 2014-12-31 Ramot At Tel-Aviv University Ltd. Omentum based scaffold and delivery system
US8946155B2 (en) 2006-02-03 2015-02-03 Opko Biologics Ltd. Long-acting polypeptides and methods of producing and administering same
WO2015015489A1 (en) 2013-07-30 2015-02-05 Biolinerx Ltd. Antibody for treating diabetes and autoimmune diseases
EP2839839A1 (en) 2007-02-28 2015-02-25 Yeda Research And Development Company Limited Nuclear targeting sequences
WO2015033344A1 (en) 2013-09-05 2015-03-12 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Methods and kits for inhibiting pathogenicity of group a streptococcus (gas) or group g streptococcus (ggs)
WO2015033337A1 (en) 2013-09-03 2015-03-12 Technion Research & Development Foundation Limited. A flap for de-novo tissue regeneration
WO2015033343A1 (en) 2013-09-03 2015-03-12 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Compositions and methods for expressing recombinant polypeptides
WO2015037009A1 (en) 2013-09-16 2015-03-19 Plexicure Ltd. Isolated proteins capable of binding plexin-a4 and methods of producing and using same
WO2015040609A1 (en) 2013-09-17 2015-03-26 Yeda Research And Development Co. Ltd. Erk-derived peptides and uses thereof
WO2015049677A1 (en) 2013-10-01 2015-04-09 Kadimastem Ltd. Directed differentiation of astrocytes from human pluripotent stem cells for use in drug screening and the treatment of amyotrophic lateral sclerosis (als)
US9018445B2 (en) 2008-08-18 2015-04-28 Evogene Ltd. Use of CAD genes to increase nitrogen use efficiency and low nitrogen tolerance to a plant
WO2015059690A1 (en) 2013-10-24 2015-04-30 Yeda Research And Development Co. Ltd. Polynucleotides encoding brex system polypeptides and methods of using s ame
WO2015059695A1 (en) 2013-10-21 2015-04-30 Opko Biologics Ltd. Long-acting polypeptides and methods of producing and administering same
WO2015063768A1 (en) 2013-10-31 2015-05-07 Biokine Therapeutics Ltd. Methods of treating acute myeloid leukemia with a flt3 mutation
WO2015079411A1 (en) 2013-11-28 2015-06-04 Tel Hashomer Medical Research Infrastructure And Services Ltd. Rna polymerase i inhibitors and uses thereof
WO2015079413A2 (en) 2013-11-28 2015-06-04 Yeda Research And Development Co. Ltd. Synaptojanin-2 inhibitors and uses thereof
US9057092B2 (en) 2006-03-06 2015-06-16 Zetiq Technologies Ltd. Methods and compositions for identifying a cell phenotype
WO2015087327A1 (en) 2013-12-10 2015-06-18 Yeda Research And Development Co. Ltd. Use of enzymes which catalyze pyruvate synthesis from formate and acetyl-coa and bacteria expressing same
EP2889041A1 (en) 2005-07-26 2015-07-01 Rutgers, The State University of New Jersey Kit of reagents for tuberculosis assay
US9096645B2 (en) 2010-11-15 2015-08-04 Ramot At Tel-Aviv University Ltd. Dipeptide analogs for treating conditions associated with amyloid fibril formation
US9096865B2 (en) 2009-06-10 2015-08-04 Evogene Ltd. Isolated polynucleotides and polypeptides, and methods of using same for increasing nitrogen use efficiency, yield, growth rate, vigor, biomass, oil content, and/or abiotic stress tolerance
WO2015114638A2 (en) 2014-02-03 2015-08-06 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Method of eliminating stem cells
WO2015114633A1 (en) 2014-01-30 2015-08-06 Yissum Research And Development Company Of The Hebrew University Of Jerusalem Ltd. Actin binding peptides and compositions comprising same for inhibiting angiogenes is and treating medical conditions associated with same
WO2015118547A1 (en) 2014-02-10 2015-08-13 Protalix Ltd. Method of maintaining disease stability in a subject having gaucher's disease
WO2015118538A1 (en) 2014-02-06 2015-08-13 Yeda Research And Development Co. Ltd. Anti cd84 antibodies, compositions comprising same and uses thereof
WO2015118537A2 (en) 2014-02-05 2015-08-13 Yeda Research And Development Co. Ltd. Micro-rnas and compositions comprising same for the treatment and diagnosis of serotonin-, adrenalin-, noradrenalin-, glutamate-, and corticotropin-releasing hormone- associated medical conditions
US9107935B2 (en) 2009-01-06 2015-08-18 Gilead Biologics, Inc. Chemotherapeutic methods and compositions
WO2015121859A1 (en) 2014-02-11 2015-08-20 Brainstorm Cell Therapeutics Ltd. Method of qualifying cells
US9121022B2 (en) 2010-03-08 2015-09-01 Monsanto Technology Llc Method for controlling herbicide-resistant plants
WO2015132784A1 (en) 2014-03-03 2015-09-11 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Method and device for detection of pseudomonas aeruginosa
EP2923709A1 (en) 2014-03-28 2015-09-30 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Multi-component-multistage malaria vaccine
US9150644B2 (en) 2011-04-12 2015-10-06 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Human monoclonal antibodies that bind insulin-like growth factor (IGF) I and II
US9156865B2 (en) 2007-04-23 2015-10-13 Deliversir Ltd System for delivering therapeutic agents into living cells and cells nuclei
WO2015159293A2 (en) 2014-04-14 2015-10-22 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. A method and kit for determining the tissue or cell origin of dna
WO2015159295A1 (en) 2014-04-17 2015-10-22 Yeda Research And Development Co. Ltd. Methods and kits for analyzing dna binding moieties attached to dna
EP2936976A1 (en) 2008-04-21 2015-10-28 Danziger Innovations Ltd. Plant viral expression vectors and use of same for generating genotypic variations in plant genomes
US9175266B2 (en) 2012-07-23 2015-11-03 Gamida Cell Ltd. Enhancement of natural killer (NK) cell proliferation and activity
WO2015166492A2 (en) 2014-04-28 2015-11-05 Yeda Research And Development Co. Ltd. Microbiome response to agents
US9182403B2 (en) 2009-05-19 2015-11-10 Zetiq Technologies Ltd. Kits for and methods of differential staining of cervical cancer cells and/or tissues
WO2015170322A2 (en) 2014-05-04 2015-11-12 Forrest Innovations Ltd. Compositions and methods of using same for increasing resistance of infected mosquitoes
WO2015177800A2 (en) 2014-05-22 2015-11-26 Yeda Research And Development Co. Ltd. Recombinant microorganisms capable of carbon fixation
WO2015186129A1 (en) 2014-06-02 2015-12-10 Technion Research & Development Foundation Limited. Compositions and methods of selectively inhibiting irp1 and treating inflammation
WO2015186128A1 (en) 2014-06-02 2015-12-10 Kadimastem Ltd. Methods of inducing myelination and maturation of oligodendrocytes
WO2015198320A1 (en) 2014-06-24 2015-12-30 Insight Biopharmaceuticals Ltd. Methods of purifying antibodies
WO2015198334A2 (en) 2014-06-25 2015-12-30 Tel Hashomer Medical Research Infrastructure And Services Ltd. Identification of cancer stem cells and use of same for diagnosis and treatment
WO2016005985A2 (en) 2014-07-09 2016-01-14 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Method for reprogramming cells
WO2016009436A1 (en) 2014-07-15 2016-01-21 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Isolated polypeptides of cd44 and uses thereof
US9249407B2 (en) 2006-02-03 2016-02-02 Opko Biologics Ltd. Long-acting coagulation factors and methods of producing same
WO2016016894A1 (en) 2014-07-30 2016-02-04 Yeda Research And Development Co. Ltd. Media for culturing pluripotent stem cells
WO2016024278A1 (en) 2014-08-14 2016-02-18 Memed Diagnostics Ltd. Computational analysis of biological data using manifold and a hyperplane
EP2990421A1 (en) 2009-04-30 2016-03-02 Tel HaShomer Medical Research Infrastructure and Services Ltd. Anti ceacam1 antibodies and methods of using same
WO2016030899A1 (en) 2014-08-28 2016-03-03 Yeda Research And Development Co. Ltd. Methods of treating amyotrophic lateral scleroses
EP2992895A1 (en) 2014-09-08 2016-03-09 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Three-component-multistage malaria vaccine
WO2016038609A1 (en) 2014-09-08 2016-03-17 Yeda Research And Development Co. Ltd. Anti-her3 antibodies and uses of same
WO2016038610A1 (en) 2014-09-08 2016-03-17 Yeda Research And Development Co. Ltd. Compositions and methods for treating cancer resistant to a tyrosine kinase inhibitor (tki)
WO2016038616A1 (en) 2014-09-14 2016-03-17 Yeda Research And Development Co. Ltd. Nmda receptor antagonists for treating gaucher disease
WO2016042561A2 (en) 2014-09-21 2016-03-24 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Downregulating mir-132 for the treatment of lipid related disorders
EP3006039A1 (en) 2004-03-02 2016-04-13 Acceleron Pharma Inc. Alk7 polypeptides for use in promoting fat loss
WO2016064887A1 (en) 2014-10-20 2016-04-28 Gen-Probe Incorporated Red blood cell lysis solution
EP3020410A1 (en) 2008-04-18 2016-05-18 Collplant Ltd. Methods of generating and using procollagen
WO2016075697A1 (en) 2014-11-13 2016-05-19 Enzootic Holdings Ltd. Functional sex-reversal of decapod crustacean females
WO2016079736A2 (en) 2014-11-17 2016-05-26 Yeda Research And Development Co. Ltd. Methods of treating diseases related to mitochondrial function
WO2016079739A2 (en) 2014-11-20 2016-05-26 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Compositions and methods for producing polypeptides with a modified glycosylation pattern in plant cells
WO2016079731A2 (en) 2014-11-17 2016-05-26 Yeda Research And Development Co. Ltd. Method of analyzing microbiome
EP3026057A2 (en) 2009-03-09 2016-06-01 Ramot at Tel Aviv University Ltd. Compositions for prevention and treatment of neurodegenerative diseases
WO2016084088A1 (en) 2014-11-26 2016-06-02 Ramot At Tel-Aviv University Ltd. Targeted elimination of bacterial genes
WO2016084084A1 (en) 2014-11-27 2016-06-02 Danziger Innovations Ltd. Nucleic acid constructs for genome editing
WO2016092555A2 (en) 2014-12-11 2016-06-16 Yeda Research And Development Co. Ltd. Isolated phosphotriesterase polypeptides, polynucleotides encoding same and uses thereof in treating or preventing organophosphate exposure associated damage
WO2016103269A1 (en) 2014-12-23 2016-06-30 Ramot At Tel-Aviv University Ltd. Populations of neural progenitor cells and methods of producing and using same
WO2016108239A1 (en) 2014-12-30 2016-07-07 Cell Cure Neurosciences Ltd. Rpe cell populations and methods of generating same
WO2016108219A1 (en) 2014-12-30 2016-07-07 Cell Cure Neurosciences Ltd. Methods of treating retinal diseases
WO2016108240A1 (en) 2014-12-30 2016-07-07 Cell Cure Neurosciences Ltd. Assessing retinal pigment epithelial cell populations
WO2016108244A1 (en) 2015-01-04 2016-07-07 Protalix Ltd. Modified dnase and uses thereof
WO2016116935A1 (en) 2015-01-21 2016-07-28 Yeda Research And Development Co. Ltd. Use of rasa2 as a prognostic and therapeutic marker for melanoma
US9416363B2 (en) 2011-09-13 2016-08-16 Monsanto Technology Llc Methods and compositions for weed control
US9422557B2 (en) 2011-09-13 2016-08-23 Monsanto Technology Llc Methods and compositions for weed control
US9422558B2 (en) 2011-09-13 2016-08-23 Monsanto Technology Llc Methods and compositions for weed control
WO2016135732A1 (en) 2015-02-26 2016-09-01 Yeda Research And Development Co. Ltd. Method of promoting hair growth
WO2016142948A1 (en) 2015-03-11 2016-09-15 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Decoy oligonucleotides for the treatment of diseases
WO2016147194A1 (en) 2015-03-19 2016-09-22 Yeda Research And Development Co. Ltd. Anti amphiregulin antibodies, compositions comprising same and uses thereof
US9458444B2 (en) 2006-02-03 2016-10-04 Opko Biologics Ltd. Long-acting coagulation factors and methods of producing same
US9458438B2 (en) 2010-04-12 2016-10-04 Ben Gurion University Of The Negev Research And Development Authority Sulfotransferase of a red microalga and uses thereof
WO2016160618A2 (en) 2015-03-27 2016-10-06 University Of Southern California Car t-cell therapy directed to lhr for the treatment of solid tumors
WO2016157192A1 (en) 2015-04-01 2016-10-06 The State Of Israel, Ministry Of Agriculture & Rural Development, Agricultural Research Organization (Aro) (Volcani Center) Erodium crassifolium l'her plant extracts and uses thereof
WO2016157190A1 (en) 2015-03-31 2016-10-06 Yeda Research And Development Co. Ltd. Glutamate oxaloacetate transaminase 1 (got1), preparations and methods of generating same and uses thereof
WO2016162870A1 (en) 2015-04-07 2016-10-13 Ilana Nathan Compositions for treating and/or preventing cell or tissue necrosis specifically targeting cathepsin c and/or cela1 and/or cela3a and/or structurally related enzymes thereto
WO2016174674A1 (en) 2015-04-27 2016-11-03 The Medical Research, Infrastructure and Health Services Fund of the Tel Aviv Medical Center Egr1 targeting molecules for the treatment of inflammatory and hyperproliferative conditions
WO2016174652A1 (en) 2015-04-30 2016-11-03 Technion Research & Development Foundation Limited Chimeric antigen receptors and methods of their use
WO2016174673A1 (en) 2015-04-29 2016-11-03 The State Of Israel, Ministry Of Agriculture & Rural Development, Agricultural Research Organization (Aro) (Volcani Center) Anti-phytopathogenic compositions
WO2016178207A1 (en) 2015-05-04 2016-11-10 Ramot At Tel-Aviv University Ltd. Methods and kits for fragmenting dna
WO2016181393A1 (en) 2015-05-11 2016-11-17 Yeda Research And Development Co. Ltd. Citrin inhibitors for the treatment of cancer
WO2016185481A2 (en) 2015-05-20 2016-11-24 Yeda Research And Development Co. Ltd. Method of targeting senescent cells
WO2016185457A1 (en) 2015-05-19 2016-11-24 Yeda Research And Development Co. Ltd. Methods of promoting lymphangiogenesis
WO2016185469A1 (en) 2015-05-21 2016-11-24 Yeda Research And Development Co. Ltd. Bacterial populations for promoting health
WO2016185471A1 (en) 2015-05-17 2016-11-24 The Medical Research, Infrastructure and Health Services Fund of the Tel Aviv Medical Center Compositions and methods for treating cancer
WO2016193969A2 (en) 2015-05-29 2016-12-08 Opko Biologics Ltd. Pegylated oxyntomodulin variants
WO2016197064A1 (en) 2015-06-04 2016-12-08 Epstein Alan L Lym-1 and lym-2 targeted car cell immunotherapy
WO2016199141A2 (en) 2015-06-08 2016-12-15 Adicet Bio Inc. Affinity entities comprising a tcr-like antibody binding domain with high affinity and fine specificity and uses of same
US9522945B2 (en) 2012-04-19 2016-12-20 Opko Biologics Ltd. Long-acting oxyntomodulin variants and methods of producing same
WO2016203482A2 (en) 2015-06-19 2016-12-22 Opko Biologics Ltd. Long-acting coagulation factors and methods of producing same
WO2016203476A1 (en) 2015-06-18 2016-12-22 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Methods and compositions for diagnosing and treating urothelial cancer
WO2016203477A1 (en) 2015-06-18 2016-12-22 Yeda Research And Development Co. Ltd. Conditioning protocols and use of same for tissue regeneration
US9540642B2 (en) 2013-11-04 2017-01-10 The United States Of America, As Represented By The Secretary Of Agriculture Compositions and methods for controlling arthropod parasite and pest infestations
EP3115451A1 (en) 2008-09-02 2017-01-11 Pluristem Ltd. Adherent cells from placenta tissue and use thereof in therapy
WO2017009853A1 (en) 2015-07-16 2017-01-19 Yeda Research And Development Co. Ltd. Genetically modified anti-third party central memory t cells and use of same in immunotherapy
WO2017009842A2 (en) 2015-07-16 2017-01-19 Biokine Therapeutics Ltd. Compositions and methods for treating cancer
US9551006B2 (en) 2010-12-22 2017-01-24 Evogene Ltd. Isolated polynucleotides and polypeptides, and methods of using same for improving plant properties
WO2017013661A1 (en) 2015-07-22 2017-01-26 Phytopharma International Ltd. Bee-ingestible compositions, methods of using same for producing honey and honey produced thereby
US9556210B2 (en) 2007-04-23 2017-01-31 Sabag-Rfa Ltd. System for delivering therapeutic agents into living cells and cells nuclei
WO2017017686A1 (en) 2015-07-29 2017-02-02 Hadasit Medical Research Services And Development Ltd. Large scale production of retinal pigment epithelial cells
WO2017021961A1 (en) 2015-08-04 2017-02-09 Yeda Research And Development Co. Ltd. Methods of screening for riboswitches and attenuators
WO2017021973A1 (en) 2015-08-05 2017-02-09 Cell Cure Neurosciences Ltd. Preparation of retinal pigment epithelium cells
WO2017021963A1 (en) 2015-08-03 2017-02-09 Biokine Therapeutics Ltd. Cxcr4 binding agents for treatment of diseases
WO2017021972A1 (en) 2015-08-05 2017-02-09 Cell Cure Neurosciences Ltd. Preparation of photoreceptors for the treatment of retinal diseases
US9567569B2 (en) 2012-07-23 2017-02-14 Gamida Cell Ltd. Methods of culturing and expanding mesenchymal stem cells
WO2017025967A1 (en) 2015-08-13 2017-02-16 Forrest Innovations Ltd. Formulations and compositions for delivery of nucleic acids to plant cells
WO2017025963A1 (en) 2015-08-10 2017-02-16 The Medical Research, Infrastructure and Health Services Fund of the Tel Aviv Medical Center Methods and pharmaceutical compositions for improving wound healing using cd24
WO2017033188A1 (en) 2015-08-24 2017-03-02 Yeda Research And Development Co. Ltd. Algal oil and biofuel and methods of producing same
WO2017042814A1 (en) 2015-09-10 2017-03-16 Yeda Research And Development Co. Ltd. Use of perforin positive immature dendritic cells in disease treatment
EP3159405A1 (en) 2010-01-05 2017-04-26 Vascular Biogenics Ltd. Methods for use of a specific anti-angiogenic adenoviral agent
WO2017072772A1 (en) 2015-10-29 2017-05-04 Yeda Research And Development Co. Ltd. A method of inducing cardiomyocytes proliferation and treating heart diseases
WO2017072773A1 (en) 2015-10-27 2017-05-04 Ilana Nathan Compositions comprising cannabidiol and second therapeutic agents for the treatment of cancer
WO2017072757A1 (en) 2015-10-25 2017-05-04 Yeda Research And Development Co. Ltd. Antibodies targeting quiescin sulfhydryl oxidase (qsox1) and uses of same
WO2017072763A1 (en) 2015-10-26 2017-05-04 Cell Cure Neurosciences Ltd. Preparation of retinal pigment epithelium cells
WO2017077539A1 (en) 2015-11-03 2017-05-11 Ariel-University Research And Development Company Ltd. Compositions for regeneration and repair of neural tissue
WO2017081689A1 (en) 2015-11-11 2017-05-18 Ramot At Tel-Aviv University Ltd. Methods of detecting 5-hydroxymethylcytosine and diagnosing of cancer
US9663778B2 (en) 2009-07-09 2017-05-30 OPKO Biologies Ltd. Long-acting coagulation factors and methods of producing same
EP3176183A1 (en) 2015-12-02 2017-06-07 Yeda Research and Development Co. Ltd Compositions and methods for treating cancer not resistant to a tyrosine kinase inhibitor (tki)
WO2017094001A1 (en) 2015-11-30 2017-06-08 Kadimastem Ltd Methods for differentiating and purifying pancreatic endocrine cells
WO2017118985A1 (en) 2016-01-06 2017-07-13 Yeda Research And Development Co. Ltd. Compositions and methods for treating malignant, autoimmune and inflammatory diseases
WO2017122203A1 (en) 2016-01-11 2017-07-20 Technion Research & Development Foundation Limited Methods of determining prognosis of sepsis and treating same
WO2017125931A1 (en) 2016-01-21 2017-07-27 The State Of Israel, Ministry Of Agriculture & Rural Development, Agricultural Research Organization (Aro) (Volcani Center) Parthenocarpic plants and methods of producing same
WO2017130205A1 (en) 2016-01-31 2017-08-03 Hadasit Medical Research Services And Development Ltd. Autosomal-identical pluripotent stem cell populations having non-identical sex chromosomal composition and uses thereof
US9726581B2 (en) 2011-12-22 2017-08-08 Realbio Technologies Ltd. Sequential lateral flow capillary device for analyte determination
WO2017134671A1 (en) 2016-02-04 2017-08-10 Yeda Research And Development Co. Ltd. Peptides and use of same in the treatment of diseases, disorders or conditions associated with a mutant p53
WO2017138007A1 (en) 2016-02-14 2017-08-17 Yeda Research And Development Co. Ltd. At The Weizmann Institute Of Science Microbiome-based diagnosis, prediction and treatment of relapsing obesity
WO2017138008A2 (en) 2016-02-14 2017-08-17 Yeda Research And Development Co. Ltd. Methods of modulating protein exocytosis and uses of same in therapy
WO2017141253A1 (en) 2016-02-16 2017-08-24 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Non-protein phenylalanine analogues for inhibiting cyanobacteria and plant growth
WO2017145162A1 (en) 2016-02-23 2017-08-31 Chaya Brodie Generation of cancer stem cells and use thereof
WO2017149547A1 (en) 2016-03-03 2017-09-08 Memed Diagnostics Ltd. Analyzing rna for diagnosing infection type
WO2017153982A1 (en) 2016-03-06 2017-09-14 Yeda Research And Development Co. Ltd. Method for modulating myelination
WO2017158610A1 (en) 2016-03-17 2017-09-21 Yeda Research And Development Co. Ltd. Methods of isolating barrel-like proteases and identifying peptides processed thereby
US9777288B2 (en) 2013-07-19 2017-10-03 Monsanto Technology Llc Compositions and methods for controlling leptinotarsa
WO2017189746A1 (en) 2016-04-27 2017-11-02 Gen-Probe Incorporated Blood cell lysis reagent
US9808534B2 (en) 2012-11-20 2017-11-07 Opko Biologics Ltd. Method of increasing the hydrodynamic volume of polypeptides by attaching to gonadotrophin carboxy terminal peptides
US9822134B2 (en) 2012-10-22 2017-11-21 Sabag-Rfa Ltd. System for delivering therapeutic agents into living cells and cells nuclei
US9828417B2 (en) 2006-02-03 2017-11-28 Opko Biologics Ltd. Long-acting polypeptides and methods of producing and administering same
WO2017203532A1 (en) 2016-05-25 2017-11-30 Yeda Research And Development Co. Ltd. At The Weizmann Institute Of Science Agents for use treating drug resistant tumors and triple negative breast cancer
WO2017203520A1 (en) 2016-05-22 2017-11-30 Yeda Research And Development Co. Ltd. Methods of using pulmonary cells for transplantation and induction of tolerance
WO2017208247A1 (en) 2016-06-02 2017-12-07 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Assay for the removal of methyl-cytosine residues from dna
WO2017212494A1 (en) 2016-06-09 2017-12-14 Opko Biologics Ltd. Long-acting oxyntomodulin formulation and methods of producing and administering same
WO2017212476A1 (en) 2016-06-05 2017-12-14 Tel Hashomer Medical Research Infrastructure And Services Ltd. Novel molecules for the treatment of inflammation
US9850496B2 (en) 2013-07-19 2017-12-26 Monsanto Technology Llc Compositions and methods for controlling Leptinotarsa
WO2017221225A1 (en) 2016-06-19 2017-12-28 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Screening for chemotherapy resistance in human haploid cells
EP3263127A1 (en) 2011-05-23 2018-01-03 Yeda Research and Development Co. Ltd Use of akt phosphorylation as a biomarker for prognosing neurodegenerative diseases and treating same
WO2018002924A1 (en) 2016-06-27 2018-01-04 Yeda Research And Development Co. Ltd. Veto cells generated from memory t cells
WO2018011799A1 (en) 2016-07-11 2018-01-18 Opko Biologics Ltd. Long-acting coagulation factor vii and methods of producing same
WO2018011805A2 (en) 2016-07-11 2018-01-18 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Systems and methods for growing cells in vitro
WO2018011804A1 (en) 2016-07-11 2018-01-18 Bonus Therapeutics Ltd. Cell compositions for tissue regeneration
WO2018011806A1 (en) 2016-07-11 2018-01-18 Yeda Research And Development Co. Ltd. Combination therapy to increase endogenous nitric oxide (no) synthesis
WO2018011796A1 (en) 2016-07-10 2018-01-18 Memed Diagnostics Ltd. Early diagnosis of infections
WO2018011795A1 (en) 2016-07-10 2018-01-18 Memed Diagnostics Ltd. Protein signatures for distinguishing between bacterial and viral infections
WO2018020489A1 (en) 2016-07-24 2018-02-01 Yeda Research And Development Co. Ltd. Methods and kits for analyzing dna binding moieties attached to dna
US9884901B2 (en) 2006-02-03 2018-02-06 Opko Biologics Ltd. Long-acting polypeptides and methods of producing and administering same
WO2018029682A1 (en) 2016-08-08 2018-02-15 Ramot At Tel-Aviv University Ltd. Bacterial systems for analyzing ubiquitylated polypeptides
WO2018029690A1 (en) 2016-08-10 2018-02-15 Memed Diagnostics Ltd. System and method for analysis of biological data
WO2018033929A1 (en) 2016-08-18 2018-02-22 Yeda Research And Development Co. Ltd. Diagnostic and therapeutic uses of exosomes
WO2018033911A1 (en) 2016-08-14 2018-02-22 Ramot At Tel-Aviv University Ltd. Mesenchymal cell-derived exosomes to treat neurological disorders
WO2018037416A1 (en) 2016-08-25 2018-03-01 Yeda Research And Development Co. Ltd. Methods and compositions for treating autoimmune diseases
WO2018047154A1 (en) 2016-09-07 2018-03-15 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Anti-nkp46 antibodies and therapeutic use of same
WO2018051347A1 (en) 2016-09-14 2018-03-22 Yeda Research And Development Co. Ltd. Crisp-seq, an integrated method for massively parallel single cell rna-seq and crispr pooled screens
US9925143B2 (en) 2012-04-18 2018-03-27 Ramot At Tel-Aviv University Ltd. Lipidated glycosaminoglycan particles for the delivery of nucleic acids
US9938316B2 (en) 2013-08-29 2018-04-10 Yeda Research And Development Co. Ltd. Selective inhibitors of α2 isoform of Na,K-ATPase and use thereof for reduction of intra-ocular pressure and as cardiotonic agents
WO2018069885A1 (en) 2016-10-13 2018-04-19 Technion Research & Development Foundation Limited Use of caspase-3 inhibitors and caspase-3 activators in the manufacture of medicament for treating cancer and wound healing
US9952211B2 (en) 2008-06-29 2018-04-24 Realbio Technologies Ltd. Liquid-transfer device particularly useful as a capturing device in a biological assay process
WO2018073823A2 (en) 2016-10-18 2018-04-26 Yeda Research And Development Co. Ltd. Treatment of a circadian rhythm disorder
WO2018087759A1 (en) 2016-11-10 2018-05-17 Yeda Research And Development Co. Ltd. Phosphotriesterases for treating or preventing organophosphate exposure associated damage
WO2018096547A1 (en) 2016-11-28 2018-05-31 Yeda Research And Development Co. Ltd. Isolated polynucleotides and polypeptides and methods of using same for expressing an expression product of interest
WO2018100511A1 (en) 2016-12-01 2018-06-07 Ramot At Tel-Aviv University Ltd. Combined treatment for nerve injuries
WO2018100574A1 (en) 2016-11-30 2018-06-07 Yeda Research And Development Co. Ltd. Methods of treating liver toxicity and disorders
WO2018134824A1 (en) 2017-01-18 2018-07-26 Yeda Research And Development Co. Ltd. Genetically modified veto cells and use of same in immunotherapy
EP3354723A1 (en) 2005-08-29 2018-08-01 Technion Research & Development Foundation Ltd. Media for culturing stem cells
WO2018142416A1 (en) 2017-02-06 2018-08-09 Yeda Research And Development Co. Ltd. Isolated cells genetically modified to express a disarm system having an anti-phage activity and methods of producing same
EP3366762A1 (en) 2007-05-07 2018-08-29 Protalix Ltd. Large scale disposable bioreactor
WO2018158775A1 (en) 2017-03-02 2018-09-07 Yeda Research And Development Co. Ltd. Methods of culturing t cells and uses of same
WO2018167778A1 (en) 2017-03-12 2018-09-20 Yeda Research And Development Co. Ltd. Methods of diagnosing and prognosing cancer
WO2018170494A1 (en) 2017-03-16 2018-09-20 Bio Time, Inc. Methods for measuring therapeutic effects of retinal disease therapies
WO2018167780A1 (en) 2017-03-12 2018-09-20 Yeda Research And Development Co. Ltd. Methods of prognosing and treating cancer
WO2018185760A1 (en) 2017-04-05 2018-10-11 Yeda Research And Development Co. Ltd. Ex-vivo culture system and methods of using same
WO2018207184A2 (en) 2017-05-10 2018-11-15 Ariel Scientific Innovations Ltd. Methods of purifying antibodies
WO2018207178A1 (en) 2017-05-07 2018-11-15 Yeda Research And Development Co. Ltd. Methods of treating psychiatric stress disorders
WO2018216011A1 (en) 2017-05-23 2018-11-29 Technion Research & Development Foundation Limited Agents which inhibit gads dimerization and methods of use thereof
WO2018216006A1 (en) 2017-05-21 2018-11-29 The Medical Research, Infrastructure and Health Services Fund of the Tel Aviv Medical Center Combination of markers for diagnosing cancer
WO2018220579A1 (en) 2017-05-31 2018-12-06 Tropic Biosciences UK Limited Compositions and methods for increasing extractability of solids from coffee beans
WO2018220581A1 (en) 2017-05-31 2018-12-06 Tropic Biosciences UK Limited Compositions and methods for increasing shelf-life of banana
WO2018220582A1 (en) 2017-05-31 2018-12-06 Tropic Biosciences UK Limited Methods of selecting cells comprising genome editing events
WO2018229764A1 (en) 2017-06-13 2018-12-20 Yeda Research And Development Co. Ltd. Treatment of advanced or progressive multiple sclerosis
US10166295B2 (en) 2011-06-02 2019-01-01 Opko Biologics Ltd. Pegylated OXM variants
WO2019012542A1 (en) 2017-07-13 2019-01-17 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Detecting tissue-specific dna
WO2019012543A1 (en) 2017-07-13 2019-01-17 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Dna targets as tissue-specific methylation markers
WO2019012544A1 (en) 2017-07-13 2019-01-17 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Dual-probe digital droplet pcr strategy for specific detection of tissue-specific circulating dna molecules
US10184131B2 (en) 2012-02-06 2019-01-22 A.B. Seeds Ltd. Isolated polynucleotides expressing or modulating microRNAs or targets of same, transgenic plants comprising same and uses thereof
WO2019021284A1 (en) 2017-07-24 2019-01-31 Yeda Research And Development Co. Ltd. Combination therapy for the treatment of cancer
WO2019035128A1 (en) 2017-08-14 2019-02-21 Yeda Research And Development Co. Ltd. Immunotherapy against transferrin receptor 1 (tfr1)-tropic arenaviruses
WO2019038771A1 (en) 2017-08-23 2019-02-28 Technion Research & Development Foundation Limited Compositions and methods for improving alcohol tolerance in yeast
US10221228B2 (en) 2006-02-03 2019-03-05 Opko Biologics Ltd. Long-acting polypeptides and methods of producing and administering same
WO2019094595A2 (en) 2017-11-09 2019-05-16 Pinteon Therapeutics Inc. Methods and compositions for the generation and use of humanized conformation-specific phosphorylated tau antibodies
WO2019097514A1 (en) 2017-11-14 2019-05-23 Yeda Research And Development Co. Ltd. Hematopoietic stem cells with improved properties
WO2019106671A1 (en) 2017-11-29 2019-06-06 Ramot At Tel-Aviv University Ltd. Methods of preventing or treating neurogenic shock
WO2019106680A1 (en) 2017-12-03 2019-06-06 Yeda Research And Development Co. Ltd. Treatment of an ischemic heart disease
WO2019106667A1 (en) 2017-11-29 2019-06-06 Weedout Ltd. Compositions, kits and methods for controlling weed of the amaranthus genus
WO2019116376A1 (en) 2017-12-17 2019-06-20 Yeda Research And Development Co. Ltd. Cop9 signalosome (csn) complex modulators and uses thereof
US10334848B2 (en) 2014-01-15 2019-07-02 Monsanto Technology Llc Methods and compositions for weed control using EPSPS polynucleotides
US10335783B2 (en) 2005-01-31 2019-07-02 Realbio Technologies, Ltd. Multistep reaction lateral flow capillary device
WO2019130313A1 (en) 2017-12-28 2019-07-04 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Method to reproduce circadian rhythms on a microfluidic chip
US10351615B2 (en) 2006-02-03 2019-07-16 Opko Biologics Ltd. Methods of treatment with long-acting growth hormone
WO2019145964A1 (en) 2018-01-29 2019-08-01 Yeda Research And Development Co. Ltd. Combination of a mek inhibitor and a cdk4/6 inhibitor for the treatment of sarcoma
WO2019150373A1 (en) 2018-01-31 2019-08-08 Yeda Research And Development Co. Ltd. Endoplasmic reticulum targeting signal
US10378012B2 (en) 2014-07-29 2019-08-13 Monsanto Technology Llc Compositions and methods for controlling insect pests
WO2019155465A1 (en) 2018-02-08 2019-08-15 Yeda Research And Development Co. Ltd. Methods of identifying and using agents for treating diseases associated with intestinal barrier dysfunction
WO2019155459A1 (en) 2018-02-08 2019-08-15 Yeda Research And Development Co. Ltd. Inhibitors of the 20s proteasome
WO2019167047A1 (en) 2018-02-28 2019-09-06 The Medical Research, Infrastructure and Health Services Fund of the Tel Aviv Medical Center Methods of diagnosing and treating bladder cancer
WO2019175869A1 (en) 2018-03-12 2019-09-19 Yeda Research And Development Co. Ltd Treatment of a heart disease
US10421785B2 (en) 2016-04-11 2019-09-24 Bar-Ilan University Delta receptor agonist peptides and use thereof
WO2019186570A1 (en) 2018-03-29 2019-10-03 Yeda Research And Development Co. Ltd. Methods of disrupting a biofilm and/or preventing formation of same
WO2019186569A1 (en) 2018-03-29 2019-10-03 Yeda Research And Development Co. Ltd. Use of electric field gradients to control gene expression
US10457954B2 (en) 2010-08-30 2019-10-29 Evogene Ltd. Isolated polynucleotides and polypeptides, and methods of using same for increasing nitrogen use efficiency, yield, growth rate, vigor, biomass, oil content, and/or abiotic stress tolerance
WO2019211750A1 (en) 2018-05-01 2019-11-07 Tropic Biosciences UK Limited Compositions and methods for reducing caffeine content in coffee beans
WO2019220441A1 (en) 2018-05-15 2019-11-21 Hadasit Medical Research Services And Development Ltd. Compositions and methods for treating cancer resistant to an anti-cancer agent
WO2019220437A1 (en) 2018-05-15 2019-11-21 Yeda Research And Development Co. Ltd. Vaccination with cancer neoantigens
WO2019229745A1 (en) 2018-05-27 2019-12-05 Biolinerx Ltd. Agi-134 combined with a checkpoint inhibitor for the treatment of solid tumors
WO2019234750A1 (en) 2018-06-07 2019-12-12 The State Of Israel, Ministry Of Agriculture & Rural Development, Agricultural Research Organization (Aro) (Volcani Center) Methods of regenerating and transforming cannabis
WO2019234754A1 (en) 2018-06-07 2019-12-12 The State Of Israel, Ministry Of Agriculture & Rural Development, Agricultural Research Organization (Aro) (Volcani Center) Nucleic acid constructs and methods of using same
WO2020003311A1 (en) 2018-06-25 2020-01-02 Yeda Research And Development Co. Ltd. Systems and methods for increasing efficiency of genome editing
WO2020008412A1 (en) 2018-07-04 2020-01-09 Ukko Inc. Methods of de-epitoping wheat proteins and use of same for the treatment of celiac disease
WO2020012467A2 (en) 2018-07-08 2020-01-16 Yeda Research And Development Co. Ltd. Person-specific assessment of probiotics responsiveness
WO2020012478A2 (en) 2018-07-11 2020-01-16 Immunity Pharma Ltd. Peptide compounds and therapeutic uses of same
WO2020012486A1 (en) 2018-07-11 2020-01-16 Kahr Medical Ltd. SIRPalpha-4-1BBL VARIANT FUSION PROTEIN AND METHODS OF USE THEREOF
US10550439B2 (en) 2014-07-21 2020-02-04 Novellusdx Ltd. Methods for determining drug response of patient specific mutations
US10550196B2 (en) 2014-04-27 2020-02-04 Famewave Ltd. Humanized antibodies against CEACAM1
WO2020026241A1 (en) 2018-07-31 2020-02-06 Collplant Ltd. Tobacco transgenic event and methods for detection and use thereof
US10557138B2 (en) 2013-12-10 2020-02-11 Beeologics, Inc. Compositions and methods for virus control in Varroa mite and bees
US10561706B2 (en) 2015-12-28 2020-02-18 B. G. Negev Technologies And Applications Isolated polypeptide and compositions comprising same
WO2020035863A1 (en) 2018-08-14 2020-02-20 Yeda Research And Development Co. Ltd. Chimeric quiescin sulfhydryl oxidase (qsox1) antibodies and uses of same
US10568328B2 (en) 2013-03-15 2020-02-25 Monsanto Technology Llc Methods and compositions for weed control
WO2020039440A1 (en) 2018-08-24 2020-02-27 Yeda Research And Development Co. Ltd. Methods of modulating m2 macrophage polarization and use of same in therapy
US10577412B2 (en) 2015-04-12 2020-03-03 Fraunhofer-Gesellschaft Zur Foerderung Der Angewandten Forschung E.V. Anti-plasmodium parasite antibodies
US10583084B2 (en) 2014-06-26 2020-03-10 Ramot At Tel-Aviv University Ltd. Liposomal formulations for delivery of nucleic acids
WO2020058979A2 (en) 2018-09-20 2020-03-26 Yeda Research And Development Co. Ltd. Methods of treating amyotrophic lateral sclerosis
WO2020065647A1 (en) 2018-09-25 2020-04-02 Biolinerx Ltd. Methods of selecting treatment for cxcr4-associated cancer
US10612019B2 (en) 2013-03-13 2020-04-07 Monsanto Technology Llc Methods and compositions for weed control
US10609930B2 (en) 2013-03-13 2020-04-07 Monsanto Technology Llc Methods and compositions for weed control
EP3633025A1 (en) 2009-11-12 2020-04-08 Technion Research & Development Foundation Ltd. Culture media, cell cultures and methods of culturing pluripotent stem cells in an undifferentiated state
WO2020089892A1 (en) 2018-10-28 2020-05-07 Yeda Research And Development Co. Ltd. Prevention of age related clonal hematopoiesis and diseases associated therewith
US10655136B2 (en) 2015-06-03 2020-05-19 Monsanto Technology Llc Methods and compositions for introducing nucleic acids into plants
WO2020105050A2 (en) 2018-11-21 2020-05-28 Yeda Research And Development Co. Ltd. Method of treating cancer and compositions for same
US10668094B2 (en) 2015-07-19 2020-06-02 Yeda Research And Development Co. Ltd. Selective inhibitors of Alpha2-containing isoforms of Na,K-ATPase and use thereof for reduction of intraocular pressure
US10683505B2 (en) 2013-01-01 2020-06-16 Monsanto Technology Llc Methods of introducing dsRNA to plant seeds for modulating gene expression
WO2020152686A1 (en) 2019-01-23 2020-07-30 Yeda Research And Development Co. Ltd. Culture media for pluripotent stem cells
WO2020161724A1 (en) 2019-02-10 2020-08-13 Yeda Research And Development Co. Ltd. Anti-matrix metalloproteinase 7 (mmp-7) inhibitory antibody and uses thereof
WO2020165907A1 (en) 2019-02-14 2020-08-20 Yeda Research And Development Co. Ltd. Spt5 inhibitors and uses thereof
WO2020170240A1 (en) 2019-02-21 2020-08-27 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Method for reduction drug-induced nephrotoxicity
WO2020170239A1 (en) 2019-02-21 2020-08-27 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Methods of generating organoids for high throughput screening of drugs
US10760088B2 (en) 2011-05-03 2020-09-01 Evogene Ltd. Isolated polynucleotides and polypeptides and methods of using same for increasing plant yield, biomass, growth rate, vigor, oil content, abiotic stress tolerance of plants and nitrogen use efficiency
US10760086B2 (en) 2011-09-13 2020-09-01 Monsanto Technology Llc Methods and compositions for weed control
US10765706B2 (en) 2015-09-03 2020-09-08 University Of South Florida Method of stem cell delivery into the brain during chronic disease using blood brain barrier permeabilizers
WO2020178822A1 (en) 2019-03-05 2020-09-10 The State Of Israel, Ministry Of Agriculture & Rural Development, Agricultural Research Organization (Aro) (Volcani Center) Genome-edited birds
WO2020183419A1 (en) 2019-03-14 2020-09-17 Tropic Biosciences UK Limited Introducing silencing activity to dysfunctional rna molecules and modifying their specificity against a gene of interest
WO2020183414A2 (en) 2019-03-14 2020-09-17 Tropic Biosciences UK Limited Modifying the specificity of non-coding rna molecules for silencing genes in eukaryotic cells
WO2020183416A1 (en) 2019-03-14 2020-09-17 Tropic Biosciences UK Limited PRODUCTION OF dsRNA IN PLANT CELLS FOR PEST PROTECTION VIA GENE SILENCING
WO2020188572A1 (en) 2019-03-19 2020-09-24 Yeda Research And Development Co. Ltd. Bistable type ii opsins and uses thereof
WO2020194317A1 (en) 2019-03-28 2020-10-01 Yeda Research And Development Co. Ltd. Method of treating lipid-related disorders
WO2020202142A2 (en) 2019-03-31 2020-10-08 Yeda Research And Development Co. Ltd. Anti-viral and anti-tumoral compounds
US10806146B2 (en) 2011-09-13 2020-10-20 Monsanto Technology Llc Methods and compositions for weed control
US10808249B2 (en) 2011-09-13 2020-10-20 Monsanto Technology Llc Methods and compositions for weed control
WO2020222241A1 (en) 2019-05-02 2020-11-05 Yeda Research And Development Co. Ltd. Compositions comprising the propeptide of lysyl oxidase and uses thereof
US10829828B2 (en) 2011-09-13 2020-11-10 Monsanto Technology Llc Methods and compositions for weed control
WO2020230133A1 (en) 2019-05-13 2020-11-19 Yeda Research And Development Co. Ltd. Cell-free mirna biomarkers for prognosis and diagnosis of neurodegenerative diseases
WO2020234875A2 (en) 2019-05-19 2020-11-26 Yeda Research And Development Co. Ltd. Identification of recurrent mutated neopeptides
WO2020234888A1 (en) 2019-05-22 2020-11-26 Hadasit Medical Research Services And Development Ltd. Methods of culturing human pluripotent cells
WO2020237491A1 (en) 2019-05-28 2020-12-03 Shanghaitech University Composition and methods to treat ectodermal dysplasia 2, clouston type
WO2020250232A1 (en) 2019-06-12 2020-12-17 Hadasit Medical Research Services And Development Ltd. Methods of generating oligodendrocytes
WO2020255124A1 (en) 2019-06-16 2020-12-24 Yeda Research And Development Co. Ltd. Method for stabilizing intracellular rna
WO2020261281A1 (en) 2019-06-27 2020-12-30 Ramot At Tel-Aviv University Ltd. Semaphorin 3a antibodies and uses thereof
US10883103B2 (en) 2015-06-02 2021-01-05 Monsanto Technology Llc Compositions and methods for delivery of a polynucleotide into a plant
WO2021001784A1 (en) 2019-07-04 2021-01-07 Ukko Inc. De-epitoped alpha gliadin and use of same for the management of celiac disease and gluten sensitivity
WO2021005599A1 (en) 2019-07-11 2021-01-14 Kahr Medical Ltd. Heterodimers and methods of use thereof
WO2021009763A1 (en) 2019-07-16 2021-01-21 Yeda Research And Development Co. Ltd. Methods of treating pain
WO2021009740A1 (en) 2019-07-16 2021-01-21 Ramot At Tel-Aviv University Ltd. Compositions and methods for the treatment of tuberculosis
US10906987B2 (en) 2016-03-01 2021-02-02 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Antibodies specific to human poliovirus receptor (PVR)
WO2021019536A1 (en) 2019-07-30 2021-02-04 The State Of Israel, Ministry Of Agriculture & Rural Development, Agricultural Research Organization (Aro) (Volcani Center) Methods of controlling cannabinoid synthesis in plants or cells and plants and cells produced thereby
WO2021019526A1 (en) 2019-07-29 2021-02-04 Yeda Research And Development Co. Ltd. Methods of treating and diagnosing lung cancer
WO2021028909A1 (en) 2019-08-12 2021-02-18 Yeda Research And Development Co. Ltd. Dna repair blood test for predicting response of lung cancer patients to immunotherapy
WO2021033176A1 (en) 2019-08-22 2021-02-25 Ariel Scientific Innovations Ltd. Scaled-up methods for purifying antibodies
WO2021038569A1 (en) 2019-08-27 2021-03-04 Yeda Research And Development Co. Ltd. Treatment of bacterial vaginosis
WO2021048852A1 (en) 2019-09-11 2021-03-18 Yeda Research And Development Co. Ltd. Methods of treating breast cancer
US10954313B2 (en) 2016-01-28 2021-03-23 Sp Nano Ltd. Composition comprising SP1 and carbon based nanoparticles and uses thereof
US10964443B2 (en) 2016-01-28 2021-03-30 Sp Nano Ltd. Conductive yarn
WO2021059269A1 (en) 2019-09-25 2021-04-01 Yeda Research And Development Co. Ltd. Assembly of protein complexes on a chip
US10968449B2 (en) 2015-01-22 2021-04-06 Monsanto Technology Llc Compositions and methods for controlling Leptinotarsa
US10988764B2 (en) 2014-06-23 2021-04-27 Monsanto Technology Llc Compositions and methods for regulating gene expression via RNA interference
WO2021084540A1 (en) 2019-10-30 2021-05-06 Yeda Research And Development Co. Ltd. Inhibitors of mmej pathway for prevention and treatment of pre-myeloid and myeloid malignancies
WO2021084526A1 (en) 2019-10-31 2021-05-06 Yeda Research And Development Co. Ltd. Engineered autotrophic bacteria for co2 conversion to organic materials
WO2021095031A2 (en) 2019-11-11 2021-05-20 Ibi-Ag Innovative Bio Insecticides Ltd. Insect control nanobodies and uses thereof
US11015229B2 (en) 2014-07-21 2021-05-25 Novellusdx Ltd. Methods and systems for determining oncogenic index of patient specific mutations
WO2021100034A1 (en) 2019-11-19 2021-05-27 Protalix Ltd. Removal of constructs from transformed cells
WO2021100041A1 (en) 2019-11-20 2021-05-27 Yeda Research And Development Co. Ltd. Treating alzheimer's disease
WO2021130752A1 (en) 2019-12-22 2021-07-01 Yeda Research And Development Co. Ltd. Systems and methods for identifying cells that have undergone genome editing
WO2021130753A1 (en) 2019-12-22 2021-07-01 Yeda Research And Development Co. Ltd. Diagnosis of frontotemporal dementia
WO2021137231A1 (en) 2019-12-31 2021-07-08 Kahr Medical Ltd. Methods of culturing t cells with a 4-1bbl fusion polypeptide and uses of same
WO2021137230A1 (en) 2019-12-31 2021-07-08 Kahr Medical Ltd. Methods of culturing t cells and uses of same
WO2021137222A1 (en) 2019-12-31 2021-07-08 Ichilov Tech Ltd. Methods of treating atopic dermatitis
WO2021144798A1 (en) 2020-01-15 2021-07-22 Immunity Pharma Ltd. Peptide compounds and methods of treating diseases using same
WO2021149053A1 (en) 2020-01-22 2021-07-29 Yeda Research And Development Co. Ltd. Multispecific antibodies for use in treating diseases
WO2021152587A1 (en) 2020-01-30 2021-08-05 Yeda Research And Development Co. Ltd. Treating acute liver disease with tlr-mik inhibitors
WO2021152592A1 (en) 2020-01-30 2021-08-05 Yeda Research And Development Co. Ltd. Methods of treating cancer
WO2021152590A1 (en) 2020-01-30 2021-08-05 Yeda Research And Development Co. Ltd. Articles of manufacture comprising anti pd-l1 antibodies and their use in therapy
WO2021152584A1 (en) 2020-01-28 2021-08-05 Ariel Scientific Innovations Ltd. Methods of analyzing cell membranes
WO2021152586A1 (en) 2020-01-30 2021-08-05 Yeda Research And Development Co. Ltd. Methods of analyzing microbiome, immunoglobulin profile and physiological state
WO2021156878A2 (en) 2020-02-09 2021-08-12 Nlc Pharma Ltd Rapid detection test for sars-cov-2
US11091770B2 (en) 2014-04-01 2021-08-17 Monsanto Technology Llc Compositions and methods for controlling insect pests
WO2021161310A1 (en) 2020-02-10 2021-08-19 Yeda Research And Development Co. Ltd. Method for analyzing cell clusters
WO2021173674A1 (en) 2020-02-26 2021-09-02 A2 Biotherapeutics, Inc. Polypeptides targeting mage-a3 peptide-mhc complexes and methods of use thereof
WO2021186431A1 (en) 2020-03-16 2021-09-23 Yeda Research And Development Co. Ltd. Peptide analogs and use of same in treating diseases, disorders or conditions associated with a mutant p53 protein
WO2021199039A1 (en) 2020-03-29 2021-10-07 Yeda Research And Development Co. Ltd. Variants of beta-glucocerebrosidase for use in treating gaucher disease
WO2021199047A1 (en) 2020-03-31 2021-10-07 Biomuse Ltd. Bacteria for the prevention and treatment of smoke-induced lung damage
WO2021205444A1 (en) 2020-04-06 2021-10-14 Yeda Research And Development Co. Ltd. Methods of diagnosing cancer and predicting responsiveness to therapy
WO2021205459A1 (en) 2020-04-07 2021-10-14 Ramot At Tel-Aviv University Ltd. Cannabidiol-containing compositions and uses thereof
EP3895697A1 (en) 2020-04-16 2021-10-20 Ichilov Tech Ltd. Cell-derived particles presenting heterologous cd24 and use thereof in therapy
WO2021209995A1 (en) 2020-04-13 2021-10-21 Exoprother Medical Ltd. Cell-derived vesicles comprising wild-type p53 protein for antiviral therapy
GB202112865D0 (en) 2021-09-09 2021-10-27 Tropic Biosciences Uk Ltd Resistance to black sigatoka disease in banana
GB202112866D0 (en) 2021-09-09 2021-10-27 Tropic Biosciences Uk Ltd Resistance to fusarium wilt in a banana
WO2021229577A1 (en) 2020-05-12 2021-11-18 Collplant Ltd. Collagen as a delivery tool for metal-based anti-viral agents
WO2021234698A1 (en) 2020-05-20 2021-11-25 Yeda Research And Development Co. Ltd. Indexing spatial information for a single-cell downstream applications
US11197915B2 (en) 2013-10-21 2021-12-14 Opko Biologics Ltd. Long-acting polypeptides and methods of producing and administering same
WO2021260675A1 (en) 2020-06-24 2021-12-30 Yeda Research And Development Co. Ltd. Agents for sensitizing solid tumors to treatment
WO2022034575A1 (en) 2020-08-09 2022-02-17 Yeda Research And Development Co. Ltd. Mage-a1 specific t cell receptor and uses thereof
WO2022034588A1 (en) 2020-08-10 2022-02-17 Yeda Research And Development Co. Ltd. Compositions for diagnosis and treatment of coronavirus infections
WO2022038536A1 (en) 2020-08-18 2022-02-24 International Rice Research Institute Methods of increasing outcrossing rates in gramineae
WO2022059015A1 (en) 2020-09-21 2022-03-24 Yeda Research And Development Co. Ltd. Method for modulating weight
WO2022064494A2 (en) 2020-09-23 2022-03-31 Yeda Research And Development Co. Ltd. Methods and compositions for treating coronaviral infections
WO2022070194A1 (en) 2020-10-01 2022-04-07 Yeda Research And Development Co. Ltd. Method of diagnosing breast cancer
WO2022074646A1 (en) 2020-10-05 2022-04-14 Protalix Ltd. Dicer-like knock-out plant cells
WO2022074656A1 (en) 2020-10-07 2022-04-14 Protalix Ltd. Long-acting dnase
WO2022079719A1 (en) 2020-10-15 2022-04-21 Yeda Research And Development Co. Ltd. Method of treating myeloid malignancies
WO2022091100A1 (en) 2020-10-29 2022-05-05 Yeda Research And Development Co. Ltd. Polynucleotides for rna editing and methods of using same
WO2022097157A2 (en) 2020-11-09 2022-05-12 1E Therapeutics, Ltd. Catalytic sequence based methods of treating or preventing bacterial infections
WO2022115498A1 (en) 2020-11-26 2022-06-02 Ukko Inc. Modified high molecular weight glutenin subunit and uses thereof
WO2022130384A1 (en) 2020-12-17 2022-06-23 Yeda Research And Development Co. Ltd. Controlling ubiquitination of mlkl for treatment of disease
WO2022144882A2 (en) 2020-12-28 2022-07-07 1E Therapeutics, Ltd. P21 mrna target areas for silencing
WO2022144883A2 (en) 2020-12-28 2022-07-07 1E Therapeutics, Ltd. P21 mrna targeting dnazymes
WO2022149142A2 (en) 2021-01-10 2022-07-14 Supermeat The Essence Of Meat Ltd. Pluripotent stem cell aggregates and microtissues obtained therefrom for the cultured meat industry
WO2022153286A1 (en) 2021-01-14 2022-07-21 Yeda Research And Development Co. Ltd. Methods of producing vitamin d
WO2022157774A1 (en) 2021-01-21 2022-07-28 Yeda Research And Development Co. Ltd. Antibodies, peptides and combinations of same for the treatment or prevention of coronavirus infection
WO2022175951A1 (en) 2021-02-18 2022-08-25 Yeda Research And Development Co. Ltd. Genetically modified bacteria for generating vaccines
WO2022175952A1 (en) 2021-02-18 2022-08-25 Yeda Research And Development Co. Ltd. Method of generating vaccines
US11427647B2 (en) 2014-04-27 2022-08-30 Famewave Ltd. Polynucleotides encoding humanized antibodies against CEACAM1
US11433163B2 (en) 2014-04-10 2022-09-06 Bonus Therapeutics Ltd. Bone repair compositions
EP4059507A1 (en) 2015-12-16 2022-09-21 Ramot at Tel-Aviv University Ltd. Particles comprising decellularized omentum
WO2022195589A2 (en) 2021-03-16 2022-09-22 Yeda Research And Development Co. Ltd. Methods and devices for ex-utero mouse embryonic development
WO2022208369A1 (en) 2021-03-30 2022-10-06 Biomx Ltd. Pseudomonas bacteriophage and uses thereof
WO2022215080A1 (en) 2021-04-08 2022-10-13 Yeda Research And Development Co. Ltd. A combined use of ketamine and retigabine (ezogabine) for the treatment of psychiatric disorders
WO2022238947A1 (en) 2021-05-12 2022-11-17 Biomx Ltd. Staphylococcus bacteriophage and uses thereof
WO2022254430A1 (en) 2021-05-30 2022-12-08 Yeda Research And Development Co. Ltd. Anti-microbial peptide (amp) signatures for diagnostics, stratification, and treatment of microbiome-associated disease
WO2022259242A1 (en) 2021-06-06 2022-12-15 Yeda Research And Development Co. Ltd. Combined treatment for cancer
NL2028466B1 (en) 2021-06-16 2022-12-21 Sakata Holland B V Methods of sorting matthiola seeds
WO2022264132A1 (en) 2021-06-13 2022-12-22 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Method for reprogramming human cells
WO2022264076A1 (en) 2021-06-16 2022-12-22 Seedx Technologies Inc. Methods of sorting matthiola seeds
WO2023275255A1 (en) 2021-07-02 2023-01-05 Tropic Biosciences UK Limited Delay or prevention of browning in banana fruit
US11555199B2 (en) 2017-09-19 2023-01-17 Tropic Biosciences UK Limited Modifying the specificity of plant non-coding RNA molecules for silencing gene expression
WO2023002492A1 (en) 2021-07-22 2023-01-26 Yeda Research And Development Co. Ltd. Codon optimization of nucleic acids
WO2023003809A1 (en) 2021-07-18 2023-01-26 Gamida-Cell Ltd. Therapeutic nk cell populations
US11571433B2 (en) 2018-02-23 2023-02-07 Carmel Haifa University Economic Corporation Ltd. Methods for treating memory impairment and cognitive dysfunction
EP4130028A1 (en) 2021-08-03 2023-02-08 Rhazes Therapeutics Ltd Engineered tcr complex and methods of using same
WO2023012584A2 (en) 2021-08-03 2023-02-09 Genicity Limited Engineered tcr complex and methods of using same
WO2023018621A1 (en) 2021-08-10 2023-02-16 Gamida-Cell Ltd. Engineered nk cells, methods of their production and uses thereof
WO2023042202A1 (en) 2021-09-14 2023-03-23 Yeda Research And Development Co. Ltd. Multispecific antibodies for use in treating diseases
US11648260B2 (en) 2018-03-29 2023-05-16 Technion Research And Development Foundation Limitted Vesicles comprising a PTEN inhibitor and uses of same
WO2023105526A1 (en) 2021-12-08 2023-06-15 Yeda Research And Development Co. Ltd. Multipotent lung progenitor cells for lung regeneration
EP4218771A1 (en) 2015-03-27 2023-08-02 Yeda Research and Development Co. Ltd Methods of treating motor neuron diseases
WO2023209708A1 (en) 2022-04-25 2023-11-02 Yeda Research And Development Co. Ltd. Compositions for altering cyclic adp-ribose secondary messenger signalling
US11807857B2 (en) 2014-06-25 2023-11-07 Monsanto Technology Llc Methods and compositions for delivering nucleic acids to plant cells and regulating gene expression

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL171930C (en) * 1972-05-11 1983-06-01 Akzo Nv METHOD FOR DETERMINING AND DETERMINING BITES AND TEST PACKAGING.
US3790447A (en) * 1972-07-05 1974-02-05 Abbott Lab Streptococci diagnostic method
GB1508132A (en) * 1974-05-20 1978-04-19 Technicon Instr Analysis of biological fluids
FR2288312A1 (en) * 1974-10-14 1976-05-14 Pasteur Institut PROGESTERONE IMMUNOENZYMATIC ASSAY PROCESS
SE388694B (en) * 1975-01-27 1976-10-11 Kabi Ab WAY TO PROVIDE AN ANTIGEN EXV IN SAMPLES OF BODY WHEATS, USING POROST BERAR MATERIAL BONDED OR ADSORBING ANTIBODIES
JPS5272284A (en) * 1975-12-12 1977-06-16 Dainippon Pharmaceutical Co Enzymeeimmunoassay reagent
JPS5539702A (en) * 1978-08-30 1980-03-19 Takeda Chem Ind Ltd Method of measuring enzyme immunity of pancreas glucagon
ES511156A0 (en) * 1981-04-13 1983-08-01 Hoechst Co American A METHOD OF DETERMINING THE PRESENCE OF AN ANTIGEN IN A LIQUID MEDIUM SUSPECTED TO CONTAIN IT.
JPS62148857A (en) * 1985-12-24 1987-07-02 Toyo Soda Mfg Co Ltd Production of material for immunological measurement
DE3636724A1 (en) * 1986-10-29 1988-06-23 Joern Dr Med Kekow Enzyme immunoassay (ELISA) for determining insulin in an microtitre plate system
US5374524A (en) * 1988-05-10 1994-12-20 E. I. Du Pont De Nemours And Company Solution sandwich hybridization, capture and detection of amplified nucleic acids
US5137804A (en) * 1988-05-10 1992-08-11 E. I. Du Pont De Nemours And Company Assay device and immunoassay
CN100591604C (en) * 2005-11-18 2010-02-24 三菱电机株式会社 Device for lighting elevator car

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3652761A (en) * 1969-09-04 1972-03-28 Corning Glass Works Immunochemical composites and antigen or antibody purification therewith
US3654090A (en) * 1968-09-24 1972-04-04 Organon Method for the determination of antigens and antibodies

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3654090A (en) * 1968-09-24 1972-04-04 Organon Method for the determination of antigens and antibodies
US3654090B1 (en) * 1968-09-24 1982-07-20
US3652761A (en) * 1969-09-04 1972-03-28 Corning Glass Works Immunochemical composites and antigen or antibody purification therewith

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Miles et al. Nature 219: 186 189 (1968). *
Nidgley et al. Karolinska Symposia on Research Methods in Reproductive Endocrinology, 1st Symposium, Sept. 23 25, 1969 in Acta Endocrinologica, Supplementum (Copenhagen), 142: 247 256 (1969). *

Cited By (1165)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
USRE31006E (en) * 1968-09-24 1982-08-03 Akzona Incorporated Process for the demonstration and determination of reaction components having specific binding affinity for each other
US4239746A (en) * 1973-06-30 1980-12-16 Dezso Istvan Bartos Complement fixation test employing reactants in a disposable package
US4162003A (en) * 1973-06-30 1979-07-24 Dezso Istvan Bartos Ready-for-use rapid test package for serological tests
US3935074A (en) * 1973-12-17 1976-01-27 Syva Company Antibody steric hindrance immunoassay with two antibodies
US4040907A (en) * 1974-06-20 1977-08-09 Syva Company Iodothyronine enzyme conjugates
US4001087A (en) * 1974-10-10 1977-01-04 The United States Of America Affinity labelling enzymes with esters of aromatic sulfonic acids
US4002532A (en) * 1974-10-21 1977-01-11 Weltman Joel K Enzyme conjugates
US4343896A (en) * 1975-02-01 1982-08-10 Akzona Incorporated Method and test pack for the demonstration and determination of an antigen or antibody
US4230797A (en) * 1975-04-28 1980-10-28 Miles Laboratories, Inc. Heterogenous specific binding assay employing a coenzyme as label
US4629688A (en) * 1975-04-28 1986-12-16 Miles Laboratories, Inc. Homogeneous specific binding assay method
USRE32696E (en) * 1975-09-04 1988-06-14 Akzona Incorporated Enzymatic immunological method for determination of antigens and antibodies
FR2325934A1 (en) * 1975-09-29 1977-04-22 Cordis Corp METHOD OF DETECTION OF THE PRESENCE OF AN ANTIGEN ASSOCIATED WITH HEPATITIS
US4474878A (en) * 1975-09-29 1984-10-02 Cordis Laboratories, Inc. Sandwich EIA for antigen associated with hepatitis
US4642285A (en) * 1975-09-29 1987-02-10 Diamedix Corporation Sandwich EIA for antigen
US4045384A (en) * 1976-07-23 1977-08-30 The Dow Chemical Company Method for forming an amide bond between a latex and protein
FR2373795A1 (en) * 1976-12-10 1978-07-07 Erba Carlo Spa IMMUNOLOGICAL DOSAGE BY FIXED ENZYME
US4200690A (en) * 1976-12-16 1980-04-29 Millipore Corporation Immunoassay with membrane immobilized antibody
US4407943A (en) * 1976-12-16 1983-10-04 Millipore Corporation Immobilized antibody or antigen for immunoassay
US4200508A (en) * 1977-02-09 1980-04-29 Hidematsu Hirai Method and composition for detecting antigenic substances
FR2390732A1 (en) * 1977-05-12 1978-12-08 Sclavo Inst Sieroterapeut PROCESS FOR DETERMINING THE CONTENTS OF CERTAIN COMPONENTS OF BIOLOGICAL FLUIDS AND MEANS USED
EP0022768A1 (en) * 1978-04-05 1981-01-28 Syva Co Macromolecular environment control in specific receptor assays.
EP0022768A4 (en) * 1978-04-05 1980-08-18 Syva Co Macromolecular environment control in specific receptor assays.
FR2435716A1 (en) * 1978-04-05 1980-04-04 Syva Co METHOD AND COMPOSITION FOR IMMUNOLOGICAL ASSAY USING A SOLID DISPERSABLE PARTICLE CONJUGATE, AN ORGANIC COMPOUND OR THE CORRESPONDING RECEPTOR
FR2434201A1 (en) * 1978-04-05 1980-03-21 Syva Co PROCESS AND NECESSARY FOR IMMUNOLOGICAL DETERMINATION AND ASSAY OF A SUBSTANCE BY CREATING A CONCENTRATED MICRO-ENVIRONMENT
US4492751A (en) * 1978-04-10 1985-01-08 Miles Laboratories, Inc. Heterogenous specific binding assay employing an enzyme substrate as label
US4318980A (en) * 1978-04-10 1982-03-09 Miles Laboratories, Inc. Heterogenous specific binding assay employing a cycling reactant as label
US5876928A (en) * 1978-04-13 1999-03-02 Institut Pasteur Method of detecting and characterizing a nucleic acid or a sequence of the latter, and enzymatic reactant for the application of this method
US5955262A (en) * 1978-04-13 1999-09-21 Institut Pasteur Method of detecting and characterizing a nucleic acid or reactant for the application of this method
US5605800A (en) * 1978-04-13 1997-02-25 Institut Pasteur Method of detecting and characterizing a nucleic acid or a sequence of the latter, and enzymatic reactant for the application of this method
US4298685A (en) * 1978-05-04 1981-11-03 Burroughs Wellcome Co. Diagnostic reagent
US4298687A (en) * 1978-10-31 1981-11-03 Roland Maes Process for the determination of compounds showing among themselves specific binding affinities by the use of a solid phase
US4260678A (en) * 1979-02-23 1981-04-07 Corning Glass Works Determining creatine kinase isoenzmes via immobilized antibody-isoenzyme complexes
US4350761A (en) * 1979-05-18 1982-09-21 Yamasu Shoyu Kabushiki Kaisha Method of and reagents for quantitative analysis of cyclic nucleotides
US4289748A (en) * 1979-05-31 1981-09-15 United States Of America Ultrasensitive enzymatic radioimmunoassay method
WO1980002747A1 (en) * 1979-05-31 1980-12-11 Rapidex Ltd Ultrasensitive enzymatic radioimmunoassay method
EP0023989A1 (en) * 1979-07-28 1981-02-18 Medac Gesellschaft für klinische Spezialpräparate mbH Enzyme-immuno assay for the detection of pathogen specific antibodies and test-kit for performing this assay
US4347311A (en) * 1979-07-28 1982-08-31 MEDAC Gesellschaft fur Klinishce Spezialpraparate mbH Enzyme immunoassay for determining antigen specific antibodies and test kit for carrying out this assay
EP0032286A2 (en) * 1979-12-26 1981-07-22 Syva Company Method for analysis for a member of an immunological pair using a test surface; kit and test surface material therefor
EP0032286A3 (en) * 1979-12-26 1981-08-05 Syva Company Method for analysis for a member of an immunological pair using a test surface; kit and test surface material therefor
US4394391A (en) * 1980-02-19 1983-07-19 Thorell Jan Ivan Radioimmunoassay reagents
US4322495A (en) * 1980-03-11 1982-03-30 Minnesota Mining And Manufacturing Co. Immunoassay
US4469796A (en) * 1980-05-19 1984-09-04 Pharmacia Diagnostics Ab Assaying methods involving biospecific affinity reactions
EP0040365A1 (en) * 1980-05-19 1981-11-25 Pharmacia Diagnostics Ab An assaying method involving biospecific affinity reactions
EP0040728A1 (en) * 1980-05-19 1981-12-02 Pharmacia Diagnostics Ab An improvement in and relating to assaying methods involving biospecific affinity reactions
US4443365A (en) * 1980-07-01 1984-04-17 Dainippon Pharmaceutical Company Limited Method for determination of the valproic acid and reagents therein
US4323647A (en) * 1980-10-15 1982-04-06 University Of Miami Steric hindrance enzyme immunoassay
EP0054675A1 (en) * 1980-12-23 1982-06-30 Roche Diagnostics GmbH Process for enzyme immuno-determination in the heterogeneous phase
WO1982004323A1 (en) * 1981-06-02 1982-12-09 O Neill Sean Immunoprecipitation assay
US4604365A (en) * 1981-06-02 1986-08-05 Electro-Nucleonics, Inc. Immunoprecipitation assay
US4506009A (en) * 1982-03-30 1985-03-19 University Of California Heterogeneous immunoassay method
US4535057A (en) * 1982-07-26 1985-08-13 Amf Incorporated Immunoassay employing monoclonal herpes simplex antibody and biotin-avidin detection system
US4515890A (en) * 1982-11-08 1985-05-07 Abbott Laboratories Immunoassay of terminal deoxynucleotidyl transferase
EP0124352A3 (en) * 1983-04-29 1986-09-17 Technicon Instruments Corporation Protected binding assay
EP0124352A2 (en) * 1983-04-29 1984-11-07 TECHNICON INSTRUMENTS CORPORATION(a Delaware corporation) Protected binding assay
US4778752A (en) * 1983-10-11 1988-10-18 Scripps Clinic And Research Foundation Receptors specific for hapten-modified self proteins
US4937199A (en) * 1985-03-18 1990-06-26 The Royal Free Hospital School Of Medicine Detection of viruses and antibodies
US4956303A (en) * 1986-04-28 1990-09-11 Antibody Technology Limited Secondary antibodies against complexes of small molecules and binding partners therefor, their preparation, and their use in diagnostic methods
US6528292B1 (en) * 1987-05-29 2003-03-04 Aventis Pharmaceuticals Holdings Inc. Derivatized polystyrene and other polymer supports for spectroscopic studies
US5256372A (en) * 1987-11-06 1993-10-26 Idexx Corporation Dipstick test device including a removable filter assembly
US5614504A (en) * 1990-08-01 1997-03-25 The University Of South Florida Method of making inosine monophosphate derivatives and immunopotentiating uses thereof
US5587294A (en) * 1991-07-19 1996-12-24 Assay Research, Inc. Method and kit for measuring endogenous cytokines
US5965379A (en) * 1991-07-19 1999-10-12 Cytimmune Sciences Inc. Method for measuring endogenous cytokines
EP0524502A2 (en) 1991-07-22 1993-01-27 Bayer Corporation Immunoassay for free analyte
US5874423A (en) * 1992-09-10 1999-02-23 Yissum Research Development Co. Of The Hebrew University Of Jerusalem Digitalis-like compounds
US5637467A (en) * 1992-10-13 1997-06-10 Behringwerke Ag Heterogeneous assay using a pendulous drop
US5837535A (en) * 1994-06-13 1998-11-17 Henry Ford Health System Neuronal-neonatal gene: neuronatin
US5843673A (en) * 1994-10-25 1998-12-01 Curators Of The University Of Missouri Method of screening for endometriosis
US6531277B2 (en) 1994-10-25 2003-03-11 The Curators Of The University Of Missouri Endometriosis-specific secretory protein
US20030152909A1 (en) * 1994-11-16 2003-08-14 Mitrani Eduardo N. In vitro micro-organs, and uses related thereto
US5607565A (en) * 1995-03-27 1997-03-04 Coulter Corporation Apparatus for measuring analytes in a fluid sample
US5728807A (en) * 1995-05-16 1998-03-17 Ramot-University Authority For Applied Research And Industrial Development, Ltd. Mutated proteins associated with ataxia-telangiectasia
US6200749B1 (en) 1995-05-16 2001-03-13 Ramot-University Authority For Applied Research And Industrial Development Ltd. Mutated forms of the ataxia-telangiectasia gene and method to screen for a partial A-T phenotype
US5858661A (en) * 1995-05-16 1999-01-12 Ramot-University Authority For Applied Research And Industrial Development Ataxia-telangiectasia gene and its genomic organization
US5777093A (en) * 1995-05-16 1998-07-07 Ramot-University Authority For Applied Research & Industrial Development Ltd. cDNAs associated with ataxia-telangiectasia
US6096508A (en) * 1995-08-16 2000-08-01 Kirkegaard & Perry Laboratoies, Inc. Method of reducing background in biotin-based assays
US5840322A (en) * 1996-12-19 1998-11-24 Ramot-University Authority For Applied Research & Industrial Devel. Ltd. Anti-oral-microbial adhesion fraction derived from vaccinium
US20030124116A1 (en) * 1997-08-21 2003-07-03 Quark Biotech, Inc. Hypoxia-regulated genes
US6740738B2 (en) 1997-08-21 2004-05-25 Quark Biotech, Inc. Antibody against hypoxia proteins
US6555667B1 (en) 1997-08-21 2003-04-29 Quark Biotech, Inc. Hypoxia-regulated genes
US7973156B2 (en) 1997-08-21 2011-07-05 Quark Pharmaceuticals Inc. Hypoxia-regulated genes
US6284496B1 (en) 1997-10-03 2001-09-04 University Of South Florida DNA vector for determining the presence of out-of-reading-frame mutations
US6482389B1 (en) 1997-10-17 2002-11-19 University Of South Florida Method to diagnose and monitor cellular immune deficiencies
US7687057B2 (en) 1998-01-09 2010-03-30 Yissum Research Development Company Of The Hebrew University Of Jerusalem In vitro micro-organs, and uses related thereto
US7855075B2 (en) 1998-02-17 2010-12-21 Gamida Cell Ltd. Methods of controlling proliferation and differentiation of stem and progenitor cells
US8202724B2 (en) 1998-02-17 2012-06-19 Gamida Cell Ltd. Methods of controlling proliferation and differentiation of stem and progenitor cells
US6344443B1 (en) 1998-07-08 2002-02-05 University Of South Florida Peptide antagonists of tumor necrosis factor alpha
US7605149B1 (en) 1998-07-13 2009-10-20 University Of South Florida Modulation of the phospholipase A2 pathway as a therapeutic
US6187563B1 (en) 1998-08-07 2001-02-13 Yale University βIV-spectrin-polypeptides and nucleic acids encoding same
US7678573B2 (en) 1999-02-04 2010-03-16 Pluristem Ltd. Method of preparing a conditioned medium from a confluent stromal cell culture
EP2208782A2 (en) 1999-02-04 2010-07-21 Pluristem Ltd. Method and apparatus for maintenance and expansion of hemopoietic stem cells and/or progenitor cells
US7534609B2 (en) 1999-02-04 2009-05-19 Pluristem Life Systems Inc. Method of expanding undifferentiated hemopoietic stem cells
US20050176143A1 (en) * 1999-02-04 2005-08-11 Technion Research & Development Method and apparatus for maintenance and expansion of hemopoietic stem cells and/or progenitor cells
EP2311938A1 (en) 1999-02-04 2011-04-20 Pluristem Ltd. Method and apparatus for maintenance and expansion of hemopoietic stem cells and/or progenitor cells
US20050176137A1 (en) * 1999-02-04 2005-08-11 Technion Research & Development Foundation Ltd. Method and apparatus for maintenance and expansion of hemopoietic stem cells and/or progenitor cells
US6440682B1 (en) * 1999-05-28 2002-08-27 Detroit R&D Inc. Detection of hypertension using immunoreactive metabolic products
US6787318B1 (en) 1999-06-01 2004-09-07 Roskamp Research Institute, Llc Assay for evaluating the therapeutic effectiveness of agents in reducing Alzheimer's disease pathology
US20050089939A1 (en) * 1999-06-01 2005-04-28 Jun Tan Assay for evaluating the therapeutic effectiveness of agents in reducing Alzheimer's disease pathology
US20060019340A1 (en) * 1999-06-08 2006-01-26 David Naor CD44 polypeptides, polynucleotides encoding same, antibodies directed thereagainst and method of using same for diagnosing and treating inflammatory diseases
US7534605B2 (en) 1999-06-08 2009-05-19 Yissum Research Development Company Of The Hebrew University Of Jerusalem CD44 polypeptides, polynucleotides encoding same, antibodies directed thereagainst and method of using same for diagnosing and treating inflammatory diseases
US8193311B2 (en) 1999-06-08 2012-06-05 Yissum Research Development Company Of The Hebrew University Of Jerusalem CD44 polypeptides, polynucleotides encoding same, antibodies directed thereagainst and method of using same for diagnosing and treating inflammatory diseases
US20030086914A1 (en) * 1999-06-25 2003-05-08 Yissum Research Development Company Of The Hebrew University Of Jerusalem Method and device for inducing biological processes by micro-organs
US20060127366A1 (en) * 1999-06-25 2006-06-15 Mitrani Eduardo N Method and device for inducing biological processes by micro-organs
US6875582B1 (en) 1999-08-19 2005-04-05 Omniscience Pharmaceuticals, Inc. Methods and targets of antibiotic resistance
US20110008314A1 (en) * 1999-08-30 2011-01-13 Yissum Research Development Company Of The Hebrew University Of Jerusalem Methods of and compositions for inhibiting the proliferation of mammalian cells
US7811981B2 (en) 1999-08-30 2010-10-12 Yissum Research Development Company Of The Hebrew University Of Jerusalem Methods of and compositions for inhibiting the proliferation of mammalian cells
US8617867B2 (en) 1999-08-30 2013-12-31 Yissum Research Develpment Company Of The Hebrew University Of Jerusalem Methods of and compositions for inhibiting the proliferation of mammalian cells
US7101839B1 (en) 1999-08-30 2006-09-05 Yissum Research Development Company Of The Hebrew University Of Jerusalem Methods of and compositions for inhibiting the proliferation of mammalian cells
US20050113327A1 (en) * 1999-08-30 2005-05-26 Levava Roiz Methods of and compositions for inhibiting the proliferation of mammalian cells
US8236543B2 (en) 1999-08-30 2012-08-07 Yissum Research Development Company Of The Hebrew University Of Jerusalem Methods of and compositions for inhibiting the proliferation of mammalian cells
US8735127B2 (en) 1999-08-30 2014-05-27 Yissum Research Development Company Of The Hebrew University Of Jerusalem Methods of and compositions for inhibiting the proliferation of mammalian cells
US6998232B1 (en) 1999-09-27 2006-02-14 Quark Biotech, Inc. Methods of diagnosing bladder cancer
US7223902B1 (en) 1999-11-19 2007-05-29 Yissum Research Development Company Of The Hebrew University Of Jerusalem Method of producing recombinant Aspergillus niger β-glucosidase and an aroma spreading plant
US20070292930A1 (en) * 1999-11-19 2007-12-20 Yissum Research Development Company Of The Hebrew University Of Jerusalem Method of producing recombinant Aspergillus niger beta-glucosidase and an aroma spreading plant
US7270810B2 (en) 2000-01-05 2007-09-18 Yeda Research And Development Co. Ltd. Veto cells effective in preventing graft rejection and devoid of graft versus host potential
US20070264274A1 (en) * 2000-01-05 2007-11-15 Yeda Research And Development Co. Ltd. Veto cells effective in preventing graft rejection and devoid of graft versus host potential
US7385106B2 (en) 2000-01-24 2008-06-10 Ramot At Tel Aviv University Ltd. Plants tolerant of environmental stress conditions, methods of generating same and novel polynucleotide sequence utilized thereby
US20030211490A1 (en) * 2000-01-24 2003-11-13 Hanan Stein Plants tolerant of environmental stress conditions, methods of generating same and novel polynucleotide sequence utilized thereby
US9095533B2 (en) 2000-03-27 2015-08-04 Technion Research & Development Foundation Limited Antigen-presenting complex-binding compositions and uses thereof
EP2316950A1 (en) 2000-03-27 2011-05-04 Technion Research and Development Foundation, Ltd. Single chain class I major histo-compatibility complexes, constructs encoding same and methods of generating same
US20030104491A1 (en) * 2000-04-30 2003-06-05 Cabantchik Ioav Zvi Molecules and methods using same for measuring non-transferrin bound iron
US8088160B2 (en) 2000-07-20 2012-01-03 Multi-Gene Vascular Systems Ltd. (“MGVS”) Drug-eluting intravascular prostheses and methods of use
US20030114410A1 (en) * 2000-08-08 2003-06-19 Technion Research And Development Foundation Ltd. Pharmaceutical compositions and methods useful for modulating angiogenesis and inhibiting metastasis and tumor fibrosis
EP2359854A1 (en) 2000-08-08 2011-08-24 Technion Research and Development Foundation, Ltd. Pharmaceutical compositions and methods useful for modulating angiogenesis
EP2359853A1 (en) 2000-08-08 2011-08-24 Technion Research and Development Foundation, Ltd. Pharmaceutical compositions and methods useful for modulating angiogenesis
EP1683874A2 (en) 2000-08-29 2006-07-26 YEDA RESEARCH AND DEVELOPMENT Co. LTD. Methods of isolating genes encoding proteins of specific function and of screening for pharmaceutically active agents
US20100055058A1 (en) * 2000-09-28 2010-03-04 Nanocyte Inc. Use of stinging cells/capsules for the delivery of active agents to keratinous substances
US20110070224A1 (en) * 2000-09-28 2011-03-24 Nanocyte Inc. Methods compositions and devices utilizing stinging cells/capsules for delivering a therapeutic or a cosmetic agent into a tissue
US8287912B2 (en) 2000-09-28 2012-10-16 Nanocyte Inc. Use of stinging cells/capsules for the delivery of active agents to keratinous substances
US8062660B2 (en) 2000-09-28 2011-11-22 Nanocyte Inc. Methods compositions and devices utilizing stinging cells/capsules for delivering a therapeutic or a cosmetic agent into a tissue
US8486441B2 (en) 2000-09-28 2013-07-16 Nanocyte Inc. Methods compositions and devices utilizing stinging cells/capsules for delivering a therapeutic or a cosmetic agent into a tissue
US20070160546A1 (en) * 2000-09-28 2007-07-12 Tamar Lotan Use of stinging cells/capsules for the delivery of active agents to keratinous substances
US20060099273A1 (en) * 2000-09-28 2006-05-11 Nanocyte Inc. Sterile preparations and compositions including stinging capsules and methods of producing and using same
US7998509B2 (en) 2000-09-28 2011-08-16 Nanocyte Inc. Use of stinging cells/capsules for the delivery of active agents to keratinous substances
US20070281037A9 (en) * 2000-09-28 2007-12-06 Nanocyte Inc. Sterile preparations and compositions including stinging capsules and methods of producing and using same
US7632522B2 (en) 2000-09-28 2009-12-15 Nanocyte Inc. Use of stinging cells/capsules for the delivery of active agents to keratinous substances
US20060159769A1 (en) * 2000-09-28 2006-07-20 Nanocyte Inc. Methods compositions and devices utilizing stinging cells/capsules for delivering a therapeutic or a cosmetic agent into a tissue
EP2186530A1 (en) 2000-11-17 2010-05-19 Vascular Biogenics Ltd. Promoters exhibiting endothelial cell specificity and methods of using same
EP2425841A1 (en) 2000-11-24 2012-03-07 Vascular Biogenics Ltd. Methods Employing and Compositions Containing Defined Oxidized Phospholipids for Prevention and Treatment of Atherosclerosis
WO2002044736A2 (en) 2000-11-30 2002-06-06 Molecular Skincare Limited Diagnosis and treatment of epidermal or skin diseases
EP2357478A2 (en) 2000-11-30 2011-08-17 Crawford Healthcare Holdings Limited Diagnosis of disease
US20040052769A1 (en) * 2000-11-30 2004-03-18 Yair Reisner Methods of utilizing cultured non-gvhd inducing t lymphocytes to treat disease
US20020142287A1 (en) * 2000-12-14 2002-10-03 Hirotaka Yamamoto High throughput assay to detect inhibitors of the map kinase pathway
US7087395B1 (en) 2001-01-16 2006-08-08 Quest Diagnostics Investments Incorporated Vitamin D assay
US20040078842A1 (en) * 2001-01-17 2004-04-22 Aviah Zilberstein Chitinases, derived from carnivorous plants polynucleotide sequences encoding thereof, and methods of isolating and using same
US20050202098A1 (en) * 2001-01-31 2005-09-15 Tolaren Disease therapy using dying or dead cells
US20050031618A1 (en) * 2001-01-31 2005-02-10 Dror Mevorach Induction of tolerance by apoptotic and/or necrotic cells
EP2308994A1 (en) 2001-03-23 2011-04-13 Yeda Research And Development Co., Ltd. Methods for determining a risk to develop cancer
US6770622B2 (en) 2001-06-08 2004-08-03 Gary A. Jarvis N-terminally truncated galectin-3 for use in treating cancer
US20050022269A1 (en) * 2001-07-19 2005-01-27 Joseph Hirschberg Polypeptides having carotenoids isomerase catalytic activity, nucleic acids encoding same and uses thereof
US7442781B2 (en) 2001-08-16 2008-10-28 Urifer Ltd. Diagnosis, prevention and treatment of cancer
US20030064058A1 (en) * 2001-09-07 2003-04-03 Nadir Askenasy Methods of utilizing bone marrow stem cells for inducing immunological tolerance
US7138144B2 (en) 2001-09-07 2006-11-21 Nadir Askenasy Method of inducing immune tolerance via blood/lymph flow-restricted bone marrow transplantation
US8415318B2 (en) 2001-10-19 2013-04-09 Vascular Biogenics Ltd. Polynucleotide constructs, pharmaceutical compositions and methods for targeted downregulation of angiogenesis and anticancer therapy
US20100088037A1 (en) * 2001-10-23 2010-04-08 Epipop Pty Ltd. Method for Identification and Development of Therapeutic Agents
US20060257865A1 (en) * 2001-10-23 2006-11-16 Simon Mallal Method for identification and development of therapeutic agents
US8178128B2 (en) 2001-12-05 2012-05-15 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Nanoparticles containing polymeric nucleic acid homologs
US20060051426A1 (en) * 2001-12-05 2006-03-09 Gershon Golomb Nanoparticles containing polymeric nucleic acid homologs pharmaceutical composition and articles of manufacture containing same and methods of use thereof
US20050085432A1 (en) * 2001-12-26 2005-04-21 Aviva Lapidot Methods of using conjugates of saccharides and acetamidino or guanidino compounds for treating bacterial infections
US7955852B2 (en) 2002-01-24 2011-06-07 Gamida Cell Ltd. Expansion of renewable stem cell populations
US20050008624A1 (en) * 2002-01-24 2005-01-13 Tony Peled Expansion of renewable stem cell populations
EP2305794A1 (en) 2002-01-24 2011-04-06 Gamida Cell Ltd. Expansion of renewable stem cell populations
US7655225B2 (en) 2002-01-25 2010-02-02 Gamida Cell, Ltd. Methods of expanding stem and progenitor cells and expanded cell populations obtained thereby
US8697634B2 (en) 2002-01-31 2014-04-15 Tel Aviv University Future Technology Development L.P. Peptides and methods using same for diagnosis and treatment of amyloid-associated disease
US7781396B2 (en) 2002-01-31 2010-08-24 Tel Aviv University Future Technology Development L.P. Peptides directed for diagnosis and treatment of amyloid-associated disease
US20060234947A1 (en) * 2002-01-31 2006-10-19 Tel Aviv University Future Technology Development L.P Peptides antibodies directed thereagainst and methods using same for diagnosing and treating amyloid-associated diseases
US20100022459A1 (en) * 2002-01-31 2010-01-28 Tel Aviv University Future Technology Development L.P Peptides directed for diagnosis and treatment of amyloid-associated diseases
US8012929B2 (en) 2002-01-31 2011-09-06 Tel Aviv University Future Technology Development L.P. Peptides directed for diagnosis and treatment of amyloid-associated diseases
US20100105608A1 (en) * 2002-01-31 2010-04-29 Tel Aviv University Future Technology Development L.P. Peptides and methods using same for diagnosis and treatment of amyloid-associated disease
US8993510B2 (en) 2002-01-31 2015-03-31 Tel Aviv University Future Technology Development L.P. Peptides and methods using same for diagnosis and treatment of amyloid-associated disease
US6992176B2 (en) 2002-02-13 2006-01-31 Technion Research & Development Foundation Ltd. Antibody having a T-cell receptor-like specificity, yet higher affinity, and the use of same in the detection and treatment of cancer, viral infection and autoimmune disease
EP2072045A2 (en) 2002-02-13 2009-06-24 Technion Research and Development Foundation, Ltd. Antibody having a t-cell receptor-like specificity, yet higher affinity, and the use of same in the detection and treatment of cancer, viral infection and autoimmune disease
US20050255101A1 (en) * 2002-02-13 2005-11-17 Technion Research And Development Foundation Ltd. Antibody having a t-cell receptor-like specificity, yet higher affinity, and the use of same in the detection and treatment of cancer, viral infection and autoimmune disease
US20050287141A1 (en) * 2002-02-13 2005-12-29 Technion Research & Development Foundation Ltd. Antibody having a T-cell receptor-like specificity, yet higher affinity, and the use of same in the detection and treatment of cancer, viral infection and autoimmune disease
EP2329814A1 (en) 2002-02-13 2011-06-08 Technion Research and Development Foundation, Ltd. Antibody having a T-cell receptor-like specificity, yet higher affinity, and the use of same in the detection and treatment of cancer
US20070196369A1 (en) * 2002-02-20 2007-08-23 Hoogenboom Henricus Renerus J MHC-peptide complex binding ligands
US7718777B2 (en) 2002-02-20 2010-05-18 Technion Research & Development Foundation Ltd. MHC-peptide complex binding ligands
US20100228007A1 (en) * 2002-02-20 2010-09-09 Technion Research & Development Foundation Ltd. Mhc-peptide complex binding ligands
US20050220774A1 (en) * 2002-03-18 2005-10-06 Tony Peled Methods of inducing differentiation in ex vivo expanded stem cells
US20060039897A1 (en) * 2002-03-26 2006-02-23 Tamar Lotan Stinging cells expressing an exogenous polycleotide encoding a therpeutic, diagnostics or a cosmetic agent and methods compositions and devices utilizing such stinging cells or capsules derive therefrom for delivering the therapeutic, diagnostic or cosmetic agent into a tissue
US20100111869A1 (en) * 2002-03-26 2010-05-06 Nanocyte Inc. Stinging cells expressing an exogenous polynucleotide encoding a therapeutic, diagnostic or a cosmetic agent and methods compositions and devices utilizing such stinging cells or capsules derived therefrom for delivering the therapeutic, diagnostic or cosmetic agent into a tissue
US8337868B2 (en) 2002-03-26 2012-12-25 Nanocyte Inc. Stinging cells expressing an exogenous polynucleotide encoding a therapeutic, diagnostic or a cosmetic agent and methods compositions and devices utilizing such stinging cells or capsules derived therefrom for delivering the therapeutic, diagnostic or cosmetic agent into a tissue
US7611723B2 (en) 2002-03-26 2009-11-03 Nanocyte Inc. Stinging cells expressing an exogenous polynucleotide encoding a therapeutic, diagnostic or a cosmetic agent and methods compositions and devices utilizing such stinging cells or capsules derived therefrom for delivering the therapeutic, diagnostic or cosmetic agent into a tissue
US20040121442A1 (en) * 2002-05-05 2004-06-24 Ilan Chet Fungal chitinase, polynucleotide sequences encoding same, promoters of same, and uses thereof
EP2561889A2 (en) 2002-08-01 2013-02-27 Yeda Research and Development Co. Ltd. Method and composition for protecting neuronal tissue from damage induced by elevated glutamate levels
US20040052928A1 (en) * 2002-09-06 2004-03-18 Ehud Gazit Peptides and methods using same for diagnosing and treating amyloid-associated diseases
US20090209041A1 (en) * 2002-09-06 2009-08-20 Tel Aviv University Future Technology Development L.P. Peptides and methods for inhibiting amyloid formation
US8563273B2 (en) 2002-09-06 2013-10-22 Tel Aviv University Future Technology Development L.P. Method of screening for compounds that disaggregate amyloid aggregates
US20070135334A1 (en) * 2002-09-06 2007-06-14 Tel Aviv University Future Technology Development L.P. Peptides and methods using same for diagnosing and treating amyloid-associated diseases
EP2182052A1 (en) 2002-10-07 2010-05-05 Technion Research and Development Foundation, Ltd. Human foreskin cells suitable for culturing stem cells
US20040146949A1 (en) * 2002-10-25 2004-07-29 Jun Tan Methods and compounds for disruption of CD40R/CD40L signaling in the treatment of alzheimer's disease
EP2295980A1 (en) 2002-10-30 2011-03-16 Yissum Research Development Company, of The Hebrew University of Jerusalem Molecules and methods using same for measuring non-transferrin bound iron
US20050054097A1 (en) * 2002-11-17 2005-03-10 Tony Peled EX-VIVO expansion of hematopoietic system cell populations in mononuclear cell cultures
US8163494B2 (en) 2002-11-27 2012-04-24 Technion Research & Development Foundation Ltd. Method for assessing metastatic properties of breast cancer
US20060127402A1 (en) * 2002-11-27 2006-06-15 Technion Research & Development Foundation Ltd. Pharmaceutical compositions and methods useful for modulating angiogenesis, inhibiting metastasis and tumor fibrosis, and assessing the malignancy of colon cancer tumors
EP2062918A2 (en) 2002-11-27 2009-05-27 Technion Research and Development Foundation, Ltd. Pharmaceutical compositions and methods useful for modulating angiogenesis, inhibiting metastasis and tumor fibrosis, and assessing the malignancy of colon cancer tumors
US8168180B2 (en) 2002-11-27 2012-05-01 Technion Research & Development Foundation Ltd. Methods and compositions for modulating angiogenesis
US20100119515A1 (en) * 2002-11-27 2010-05-13 Gera Neufeld Pharmaceutical compositions and methods useful for modulating angiogenesis, inhibiting metastasis and tumor fibrosis, and assessing the malignancy of colon cancer tumors
EP2062919A2 (en) 2002-11-27 2009-05-27 Technion Research and Development Foundation, Ltd. Pharmaceutical compositions and methods useful for modulating angiogenesis, inhibiting metastasis and tumor fibrosis, and assessing the malignancy of colon cancer tumors
US8815823B2 (en) 2002-11-27 2014-08-26 Technion Research & Development Foundation Ltd. Pharmaceutical compositions and methods useful for modulating angiogenesis, inhibiting metastasis and tumor fibrosis, and assessing the malignancy of colon cancer tumors
US7947499B2 (en) 2002-11-29 2011-05-24 Technion Research & Development Foundation Ltd. Method of dynamically culturing embryonic stem cells
US20060148078A1 (en) * 2002-11-29 2006-07-06 Sharon Gerecht-Nir Method of dynamically culturing embryonic stem cells
US20110027887A1 (en) * 2002-11-29 2011-02-03 Technion Research & Development Foundation Ltd. Method of dynamically culturing embryonic stem cells
US20090123553A1 (en) * 2002-12-09 2009-05-14 Ramot At Tel Aviv University Ltd. Peptide nanostructures and methods of generating and using the same
US8053554B2 (en) 2002-12-09 2011-11-08 Ramot At Tel-Aviv University Ltd. Peptide nanostructures and methods of generating and using the same
EP2338896A2 (en) 2002-12-12 2011-06-29 R.B.T. (Rakuto Bio Technologies) Ltd. Use of lignin peroxidase in skin and hair lightening
EP2457999A2 (en) 2002-12-16 2012-05-30 Technion Research & Development Foundation Ltd. Culture medium for pluropotent stem cells
WO2004060135A2 (en) 2003-01-02 2004-07-22 Rappaport Family Institute For Research In The Medical Sciences Methods of predicting a benefit of antioxidant therapy for prevention of cardiovascular disease in hyperglycemic patients
US20090121709A1 (en) * 2003-01-07 2009-05-14 Ramot At Tel Aviv University Ltd. Peptide nanostructures encapsulating A foreign material and method of manufacturing same
US8017586B2 (en) 2003-01-07 2011-09-13 Ramot At Tel-Aviv University Ltd. Peptide nanostructures encapsulating a foreign material and method of manufacturing same
EP2058275A1 (en) 2003-01-07 2009-05-13 Ramot at Tel-Aviv University Ltd. Peptide nanostructures encapsulating a foreign material and method of manufacturing same
EP2319857A2 (en) 2003-03-04 2011-05-11 Yeda Research And Development Co., Ltd. Pon polypeptides, polynucleotides encoding same and compositions and methods utilizing same
EP2216033A2 (en) 2003-03-06 2010-08-11 Yeda Research and Development Co. Ltd. Methods of treating disease by transplantation of allogeneic or xenogeneic organs or tissues
US20050054103A1 (en) * 2003-03-07 2005-03-10 Tony Peled Expansion of renewable stem cell populations using modulators of PI 3-kinase
US9616112B2 (en) 2003-03-26 2017-04-11 Technion Research & Development Foundation Limited Compositions capable of specifically binding particular human antigen presenting molecule/pathogen-derived antigen complexes and uses thereof
US20050152912A1 (en) * 2003-03-26 2005-07-14 Technion Research & Development Foundation Ltd. Compositions capable of specifically binding particular human antigen presenting molecule/pathogen-derived antigen complexes and uses thereof
US20100080805A1 (en) * 2003-03-26 2010-04-01 Technion Research & Development Compositions capable of specifically binding particular human antigen presenting molecule/pathogen-derived antigen complexes and uses thereof
US20060083735A1 (en) * 2003-03-26 2006-04-20 Technion Research & Development Foundation Ltd. Antigen-presenting complex-binding compositions and uses thereof
US9023348B2 (en) 2003-03-26 2015-05-05 Technion Research & Development Foundation Limited Compositions capable of specifically binding particular human antigen presenting molecule/pathogen-derived antigen complexes and uses thereof
US7638124B2 (en) 2003-03-26 2009-12-29 Technion Research & Development Foundation Ltd. Antigen-presenting complex-binding compositions and uses thereof
US7632923B2 (en) 2003-03-26 2009-12-15 Technion Research & Development Foundation Ltd. Compositions capable of specifically binding particular human antigen presenting molecule/pathogen-derived antigen complexes and uses thereof
US20040197334A1 (en) * 2003-04-02 2004-10-07 Technion Research & Development Foundation Ltd. Antibody fragment capable of modulating multidrug resistance and compositions and kits and methods using same
US7294701B2 (en) 2003-04-02 2007-11-13 Technion Research & Development Foundation Ltd. Antibody fragment capable of modulating multidrug resistance and compositions and kits and methods using same
EP2330132A1 (en) 2003-04-04 2011-06-08 Yeda Research and Development Co. Ltd. Antibodies and pharmaceutical compositions containing same useful for inhibiting activity of metalloproteins
US8252588B2 (en) 2003-04-08 2012-08-28 Yeda Research And Development Co. Ltd. Stem cells having increased sensitivity to SDF-1 and methods of generating and using same
US8388954B2 (en) 2003-04-09 2013-03-05 Laboratoire Francais Du Fractionnement Et Des Biotechnologies Stabilising formulation for immunoglobulin G compositions in liquid form and in lyophilised form
US9463241B2 (en) 2003-04-09 2016-10-11 Laboratoire Francais Du Fractionnement Et Des Biotechnologies Method for stabilising an immunoglobulin G composition in liquid form
US7355079B2 (en) 2003-04-18 2008-04-08 The Regents Of The University Of California Thyronamine derivatives and analogs and methods of use thereof
US20060035980A1 (en) * 2003-04-18 2006-02-16 Scanlan Thomas S Thyronamine derivatives and analogs and methods of use thereof
US20090260109A1 (en) * 2003-05-22 2009-10-15 Evogene Ltd. Methods of increasing abiotic stress tolerance and/or biomass in plants genterated thereby
US10184132B2 (en) 2003-05-22 2019-01-22 Evogene Ltd. Methods of increasing abiotic stress tolerance, yield and/or biomass in plants
EP2365087A2 (en) 2003-05-22 2011-09-14 Evogene Ltd. Methods of increasing abiotic stress tolerance and/or biomass in plants and plants generated thereby
US7554007B2 (en) 2003-05-22 2009-06-30 Evogene Ltd. Methods of increasing abiotic stress tolerance and/or biomass in plants
US20060123516A1 (en) * 2003-05-22 2006-06-08 Gil Ronen Methods of increasing abiotic stress tolerance and/or biomass in plants and plants generated thereby
US9303269B2 (en) 2003-05-22 2016-04-05 Evogene Ltd. Methods of increasing abiotic stress tolerance and/or biomass in plants
US8481812B2 (en) 2003-05-22 2013-07-09 Evogene Ltd. Methods of increasing abiotic stress tolerance and/or biomass in plants generated thereby
US20050020499A1 (en) * 2003-05-27 2005-01-27 Bar Ilan University Methods of attenuating cocaine seeking behavior employing glial cell-derived neurotrophic factor (GDNF) and pharmaceutical compositions and articles of manufacture suited for use in practice of the method
US20090253170A1 (en) * 2003-06-19 2009-10-08 Evogene Ltd. Nucleotide sequences for regulating gene expression in plant trichomes and constructs and methods utilizing same
US7498428B2 (en) 2003-06-19 2009-03-03 Evogene Ltd. Nucleotide sequences for regulating gene expression in plant trichomes and constructs and methods utilizing same
US20060260002A1 (en) * 2003-06-19 2006-11-16 Gil Ronen Nucleotide sequences for regulating gene expression in plant trichomes and constructs and methods utilizing same
US8129514B2 (en) 2003-06-19 2012-03-06 Evogene Ltd. Nucleotide sequences for regulating gene expression in plant trichomes and constructs and methods utilizing same
EP2719394A1 (en) 2003-06-30 2014-04-16 Tel Aviv University Future Technology Development L.P. Peptides antibodies directed thereagainst for diagnosing and treating amyloid-associated diseases
EP2540302A1 (en) 2003-07-15 2013-01-02 Bar-Ilan University Methods and pharmaceutical compositions for healing wounds
EP2526952A1 (en) 2003-07-15 2012-11-28 Bar-Ilan University Methods and pharmaceutical compositions for healing wounds
EP2526953A1 (en) 2003-07-15 2012-11-28 Bar-Ilan University Methods and pharmaceutical compositions for healing wounds
EP2540301A2 (en) 2003-07-15 2013-01-02 Bar-Ilan University Methods and pharmaceutical compositions for healing wounds
US20050271643A1 (en) * 2003-08-14 2005-12-08 Iryna Sorokulova Bacterial strains, compositions including same and probiotic use thereof
US7625707B2 (en) 2003-10-02 2009-12-01 Ramot At Tel Aviv University Ltd. Antibacterial agents and methods of identifying and utilizing same
EP2354164A1 (en) 2003-10-07 2011-08-10 Yeda Research And Development Co., Ltd. Anti-NIK antibodies and uses thereof
WO2005033142A2 (en) 2003-10-07 2005-04-14 Yeda Research And Development Co. Ltd. Anti-nik antibodies and uses thereof
WO2005033145A1 (en) 2003-10-07 2005-04-14 Yeda Research And Development Co. Ltd. Antibodies to nik, their preparation and use
EP2322561A1 (en) 2003-10-07 2011-05-18 Yeda Research And Development Co., Ltd. Anti-NIK antibodies and uses thereof
US20060257429A1 (en) * 2003-10-23 2006-11-16 Dreier Kimberly J Vaccine for periodontal disease
WO2005051423A2 (en) 2003-11-30 2005-06-09 Yeda Research And Development Co. Ltd Methods and agents for immune modulation and methods for identifying immune modulators
US7790673B2 (en) 2003-12-12 2010-09-07 New York University Methods and compositions relating to cystatin C
US20070032421A1 (en) * 2003-12-12 2007-02-08 Efrat Levy Methods and compositions relating to cystatin C
US20100221233A1 (en) * 2003-12-15 2010-09-02 University Of South Florida Compositions and methods for enhancing neuroprotection via administration of stem cells and blood brain barrier permeabilizers
EP2289567A2 (en) 2003-12-22 2011-03-02 Regentis Biomaterials Ltd. Matrix comprising naturally-occurring crosslinked protein backbone
US8007847B2 (en) 2004-01-13 2011-08-30 Eytan Biderman Feeding formula appliance
US20080312179A1 (en) * 2004-01-20 2008-12-18 Insight Biopharmaceuticals Ltd. High level expression of recombinant human erythropoietin having a modified 5'-UTR
US20050158822A1 (en) * 2004-01-20 2005-07-21 Insight Biopharmaceuticals Ltd. High level expression of recombinant human erythropoietin having a modified 5'-UTR
US7423139B2 (en) 2004-01-20 2008-09-09 Insight Biopharmaceuticals Ltd. High level expression of recombinant human erythropoietin having a modified 5′-UTR
US7893240B2 (en) 2004-01-20 2011-02-22 Insight Biopharmaceuticals Ltd. High level expression of recombinant human erythropoietin having a modified 5′-UTR
US20110091454A1 (en) * 2004-01-27 2011-04-21 Alex Diber Methods and systems for annotating biomolecular sequences
EP3006039A1 (en) 2004-03-02 2016-04-13 Acceleron Pharma Inc. Alk7 polypeptides for use in promoting fat loss
US8352031B2 (en) 2004-03-10 2013-01-08 Impulse Dynamics Nv Protein activity modification
US9012728B2 (en) 2004-06-14 2015-04-21 Evogene Ltd. Polynucleotides and polypeptides involved in plant fiber development and methods of using same
US20090126042A1 (en) * 2004-06-14 2009-05-14 Evogene Ltd. Polynucleotides and polypeptides involved in plant fiber development and methods of using same
US8962915B2 (en) 2004-06-14 2015-02-24 Evogene Ltd. Isolated polypeptides, polynucleotides encoding same, transgenic plants expressing same and methods of using same
EP2336330A2 (en) 2004-06-14 2011-06-22 Evogene Ltd. Polynucleotides and polypeptides involved in plant fiber development and methods of using same
EP2343373A1 (en) 2004-06-14 2011-07-13 Evogene Ltd. Polynucleotides and polypeptides involved in plant fiber development and methods of using same
US20080004234A1 (en) * 2004-07-06 2008-01-03 Segev Laboratories Limited System for delivering therapeutic agents into living cells and cells nuclei
US8680062B2 (en) 2004-07-06 2014-03-25 Deliversir Ltd. System for delivering therapeutic agents into living cells and cells nuclei
US20090156471A1 (en) * 2004-07-15 2009-06-18 Ramot At Tel Aviv University Ltd. Use of anti-amyloid agents for treating and typing pathogen infections
US8080417B2 (en) 2004-09-16 2011-12-20 Gamida-Cell Ltd. Methods of ex vivo hematopoietic stem cell expansion by co-culture with mesenchymal cells
US8000900B2 (en) 2004-09-21 2011-08-16 Microsoft Corporation Association-based predictions of pathogen characteristics
US8039240B2 (en) 2004-09-29 2011-10-18 Yissum Reseach Development Company Of The Hebrew University Of Jerusalem Recombinant human T2 RNase and uses thereof
EP2816117A2 (en) 2004-09-29 2014-12-24 Collplant Ltd. Collagen producing plants and methods of generating and using same
EP3088528A1 (en) 2004-09-29 2016-11-02 Collplant Ltd. Collagen producing plants and methods of generating and using same
US20080131419A1 (en) * 2004-09-29 2008-06-05 Yissum Research Development Company Of The Hebrew University Of Jerusalem Recombinant Human T2 Rnase and Uses Thereof
US7781402B2 (en) 2004-10-12 2010-08-24 Closed Loop Therapies Ltd. Methods and implantable devices for treating supraventricular arrhythmias
US20060079941A1 (en) * 2004-10-12 2006-04-13 Eli Ovsyshcher Methods and implantable devices for treating supraventricular arrhythmias
US20110040248A1 (en) * 2004-10-12 2011-02-17 Closed Loop Therapies Bv Methods and implantable devices for treating supraventricular arrhythmias
US20060095241A1 (en) * 2004-10-29 2006-05-04 Microsoft Corporation Systems and methods that utilize machine learning algorithms to facilitate assembly of aids vaccine cocktails
US8478535B2 (en) 2004-10-29 2013-07-02 Microsoft Corporation Systems and methods that utilize machine learning algorithms to facilitate assembly of aids vaccine cocktails
US20060190226A1 (en) * 2004-10-29 2006-08-24 Microsoft Corporation Systems and methods that utilize machine learning algorithms to facilitate assembly of aids vaccine cocktails
EP2174668A2 (en) 2004-11-14 2010-04-14 Vascular Biogenics Ltd. Promoters exhibiting endothelial cell specificity and methods of using same for regulation of angiogenesis
US20060134680A1 (en) * 2004-12-22 2006-06-22 Alexander Kotlyar Homogeneous populations of nucleic acids, methods of synthesyzing same and uses thereof
US8375327B2 (en) 2005-01-16 2013-02-12 Zlango Ltd. Iconic communication
US20080082678A1 (en) * 2005-01-16 2008-04-03 Zlango Ltd. Communications Network System and Methods for Using Same
US20090013087A1 (en) * 2005-01-18 2009-01-08 Zlango Ltd. Communications Network System and Methods For Using Same
US8019818B2 (en) 2005-01-18 2011-09-13 Zlango Ltd. Communications network system and methods for using same
US10335783B2 (en) 2005-01-31 2019-07-02 Realbio Technologies, Ltd. Multistep reaction lateral flow capillary device
EP2316441A1 (en) 2005-02-17 2011-05-04 Hadasit Medical Research Services And Development Bisphosphonates for treating endometriosis
WO2006090388A2 (en) 2005-02-25 2006-08-31 The State Of Israel, Ministry Of Agriculture & Rural Development, Agricultural Research Organization, (A.R.O.), Volcani Center Fruit cell culture extract for treating inflammation
US20060211064A1 (en) * 2005-03-18 2006-09-21 Hyesook Kim Detection of hypertension using glucuronidated metabolic products
US7695927B2 (en) 2005-03-18 2010-04-13 Detroit R & D Detection of hypertension using glucuronidated metabolic products
US20090068207A1 (en) * 2005-04-15 2009-03-12 Vascular Biogenics Ltd. Compositions Containing Beta 2-Glycoprotein I-Derived Peptides for the Prevention and/or Treatment of Vascular Disease
US20060234203A1 (en) * 2005-04-19 2006-10-19 Nanocyte Inc. Methods, compositions and devices utilizing stinging cells/capsules for conditioning a tissue prior to delivery of an active agent
US8834862B2 (en) 2005-04-19 2014-09-16 Nanocyte Inc. Methods, compositions and devices utilizing stinging cells/capsules for conditioning a tissue prior to delivery of an active agent
US11359185B2 (en) 2005-04-28 2022-06-14 Ventana Medical Systems, Inc. Antibody conjugates
US9315789B2 (en) 2005-04-28 2016-04-19 Ventana Medical Systems, Inc. Antibody conjugates
US8658389B2 (en) 2005-04-28 2014-02-25 Ventana Medical Systems, Inc. Antibody conjugates
US20090176253A1 (en) * 2005-04-28 2009-07-09 Christopher Bieniarz Antibody conjugates
US20090181398A1 (en) * 2005-04-28 2009-07-16 Christina Bauer Nanoparticle conjugates
US20060246523A1 (en) * 2005-04-28 2006-11-02 Christopher Bieniarz Antibody conjugates
US20060246524A1 (en) * 2005-04-28 2006-11-02 Christina Bauer Nanoparticle conjugates
US9567568B2 (en) 2005-05-04 2017-02-14 Enlivex Therapeutics Ltd. Method of preparing apoptotic monocytes
EP2279726A2 (en) 2005-05-26 2011-02-02 Biorest Ltd. Compositions and methods using same for delivering agents into a target organ protected by a blood barrier
WO2006134602A2 (en) 2005-06-16 2006-12-21 Ramot At Tel Aviv University Ltd. Isolated cells and populations comprising same for the treatment of cns diseases
EP2465924A2 (en) 2005-06-16 2012-06-20 Ramot at Tel-Aviv University Ltd. Isolated cells and populations comprising same for the treament of cns diseases
US20070225242A1 (en) * 2005-06-21 2007-09-27 The Board Of Trustees Of The Leland Stanford Junior University Method and composition for treating and preventing tumor metastasis in vivo
US8067573B2 (en) 2005-07-07 2011-11-29 Yissum Research Development Company Of The Hebrew University Of Jerusalem Nucleic acid agents for downregulating H19 and methods of using same
EP2487182A2 (en) 2005-07-07 2012-08-15 FULCRUM SP Ltd. SP1 polypeptides, modified SP1 polypeptides and uses thereof
US8067574B2 (en) 2005-07-07 2011-11-29 Yissum Research Development Company Of The Hebrew University Of Jerusalem Nucleic acid agents for downregulating H19, and methods of using same
US20090143321A1 (en) * 2005-07-07 2009-06-04 Avraham Hochberg Nucleic acid agents for downregulating h19 and methods of using same
EP2484768A2 (en) 2005-07-18 2012-08-08 Protalix Ltd. Mucosal or enteral administration of biologically active macromolecules
EP2441840A1 (en) 2005-07-18 2012-04-18 Protalix Ltd. Mucosal or enteral administration of biologically active macromolecules
EP2889041A1 (en) 2005-07-26 2015-07-01 Rutgers, The State University of New Jersey Kit of reagents for tuberculosis assay
US20100068135A1 (en) * 2005-08-08 2010-03-18 Onconon, Llc Antibody compositions, methods for treating neoplastic disease and methods for regulating fertility
US8642330B2 (en) 2005-08-08 2014-02-04 Onconon, Llc Antibody compositions, methods for treating neoplastic disease and methods for regulating fertility
WO2007020638A2 (en) 2005-08-15 2007-02-22 Evogene Ltd. Methods of increasing abiotic stress tolerance and/or biomass in plants and plants generated thereby
EP2995194A1 (en) 2005-08-15 2016-03-16 Evogene Ltd. Methods of increasing abiotic stress tolerance and/or biomass in plants and plants generated thereby
US9487796B2 (en) 2005-08-15 2016-11-08 Evogene Ltd. Methods of increasing abiotic stress tolerance and/or biomass in plants and plants generated thereby
US20090089898A1 (en) * 2005-08-15 2009-04-02 Hagai Karchi Methods of increasing abiotic stress tolerance and/or biomass in plants and plants generated thereby
US7910800B2 (en) 2005-08-15 2011-03-22 Evogene Ltd. Methods of increasing abiotic stress tolerance and/or biomass in plants and plants generated thereby
WO2007023491A2 (en) 2005-08-24 2007-03-01 Yeda Research And Development Co. Ltd. Universal donor-derived tolerogenic cells for inducing non-syngeneic transplantation tolerance
EP2514315A2 (en) 2005-08-24 2012-10-24 Yeda Research and Development Co. Ltd. Universal donor-derived tolerogenic cells for inducing non-syngeneic transplantation tolerance
EP3354723A1 (en) 2005-08-29 2018-08-01 Technion Research & Development Foundation Ltd. Media for culturing stem cells
WO2007031996A1 (en) 2005-09-12 2007-03-22 Rappaport Family Institute For Research In The Medical Sciences Compositions and methods for diagnosing and treating an inflammation
WO2007034487A1 (en) 2005-09-22 2007-03-29 Yissum Research Development Company Of The Hebrew University Of Jerusalem Nucleic acid constructs, pharmaceutical compositions and methods of using same for treating cancer
US20090221681A1 (en) * 2005-09-22 2009-09-03 Yissum Research Development Company Of The Hebrew University Of Jerusalem Nucleic acid constructs, pharmaceutical compositions and methods of using same for treating cancer
US8034914B2 (en) 2005-09-22 2011-10-11 Yissum Research Development Company Of The Hebrew University Of Jerusalem Nucleic acid constructs, pharmaceutical compositions and methods of using same for treating cancer
US20070087437A1 (en) * 2005-10-14 2007-04-19 Jifan Hu Methods for rejuvenating cells in vitro and in vivo
EP2716654A1 (en) 2005-10-24 2014-04-09 Evogene Ltd. Isolated polypeptides, polynucleotides encoding same, transgenic plants expressing same and methods of using same
US20100136652A1 (en) * 2005-11-23 2010-06-03 Christopher Bieniarz Molecular Conjugate
US8686122B2 (en) 2005-11-23 2014-04-01 Ventana Medical Systems, Inc. Molecular conjugate
US9310373B2 (en) 2005-11-23 2016-04-12 Ventana Medical Systems, Inc. Molecular conjugate
US20070117153A1 (en) * 2005-11-23 2007-05-24 Christopher Bieniarz Molecular conjugate
EP2390312A1 (en) 2005-11-29 2011-11-30 Gamida Cell Ltd. Methods of improving stem cell homing and engraftment
US8846393B2 (en) 2005-11-29 2014-09-30 Gamida-Cell Ltd. Methods of improving stem cell homing and engraftment
US20110116972A1 (en) * 2005-12-12 2011-05-19 Mats Holmquist Microfluidic assays and microfluidic devices
US20070134739A1 (en) * 2005-12-12 2007-06-14 Gyros Patent Ab Microfluidic assays and microfluidic devices
EP2237037A1 (en) 2005-12-12 2010-10-06 Gyros Patent Ab Microfluidic device and use thereof
US8775526B2 (en) 2006-01-16 2014-07-08 Zlango Ltd. Iconic communication
US20070190610A1 (en) * 2006-02-03 2007-08-16 Fuad Fares Long-acting EPO polypeptides and derivatives thereof and methods thereof
US10221228B2 (en) 2006-02-03 2019-03-05 Opko Biologics Ltd. Long-acting polypeptides and methods of producing and administering same
US8426166B2 (en) 2006-02-03 2013-04-23 Prolor Biotech Inc. Long-acting polypeptides and methods of producing same
US8450269B2 (en) 2006-02-03 2013-05-28 Prolor Biotech Ltd. Long-acting growth hormone and methods of producing same
EP2853541A1 (en) 2006-02-03 2015-04-01 OPKO Biologics Ltd. Long-acting polypeptides and uses thereof
US8465948B2 (en) 2006-02-03 2013-06-18 Prolor Biotech Ltd. Long-acting veterinary polypeptides and methods of producing and administering same
EP2853536A1 (en) 2006-02-03 2015-04-01 OPKO Biologics Ltd. Long-acting erythropoietin polypeptides and uses thereof
US8999670B2 (en) 2006-02-03 2015-04-07 Opko Biologics Ltd. Long-acting polypeptides and methods of producing same
US10119132B2 (en) 2006-02-03 2018-11-06 Opko Biologics Ltd. Long-acting coagulation factors and methods of producing same
US8946155B2 (en) 2006-02-03 2015-02-03 Opko Biologics Ltd. Long-acting polypeptides and methods of producing and administering same
US10144921B2 (en) 2006-02-03 2018-12-04 Opko Biologics Ltd. Long-acting coagulation factors and methods of producing same
EP2532674A1 (en) 2006-02-03 2012-12-12 Modigene Inc Long-acting polypeptides and methods of producing and administering same
WO2007094985A2 (en) 2006-02-03 2007-08-23 Modigene Inc Long-acting polypeptides and methods of producing and administering same
EP2532675A1 (en) 2006-02-03 2012-12-12 Modigene Inc Long-acting polypeptides and methods of producing and administering same
US9249407B2 (en) 2006-02-03 2016-02-02 Opko Biologics Ltd. Long-acting coagulation factors and methods of producing same
US9828417B2 (en) 2006-02-03 2017-11-28 Opko Biologics Ltd. Long-acting polypeptides and methods of producing and administering same
US9884901B2 (en) 2006-02-03 2018-02-06 Opko Biologics Ltd. Long-acting polypeptides and methods of producing and administering same
EP2471807A1 (en) 2006-02-03 2012-07-04 Modigene Inc Long-acting polypeptides and methods of producing and administering same
US10351615B2 (en) 2006-02-03 2019-07-16 Opko Biologics Ltd. Methods of treatment with long-acting growth hormone
US7553940B2 (en) 2006-02-03 2009-06-30 Modigene Inc Long-acting EPO polypeptides and derivatives thereof and methods thereof
US7553941B2 (en) 2006-02-03 2009-06-30 Modigene Inc Long-acting polypeptides and methods of producing same
US8323636B2 (en) 2006-02-03 2012-12-04 Prolor Biotech Ltd. Long-acting interferons and derivatives thereof and methods thereof
US20070190611A1 (en) * 2006-02-03 2007-08-16 Fuad Fares Long-acting polypeptides and methods of producing same
US10030060B2 (en) 2006-02-03 2018-07-24 Opko Biologics Ltd. Long-acting polypeptides and methods of producing same
US9896494B2 (en) 2006-02-03 2018-02-20 Opko Biologics Ltd. Long-acting polypeptides and methods of producing same
US8759292B2 (en) 2006-02-03 2014-06-24 Prolor Biotech, Llc Long-acting coagulation factors and methods of producing same
US11066658B2 (en) 2006-02-03 2021-07-20 Opko Biologics Ltd. Long-acting coagulation factors and methods of producing same
US20070184530A1 (en) * 2006-02-03 2007-08-09 Fuad Fares Long-acting veterinary polypeptides and methods of producing and administering same
US9908924B2 (en) 2006-02-03 2018-03-06 Opko Biologics Ltd. Long-acting polypeptides and methods of producing and administering same
US9458444B2 (en) 2006-02-03 2016-10-04 Opko Biologics Ltd. Long-acting coagulation factors and methods of producing same
US10640758B2 (en) 2006-02-03 2020-05-05 Opko Biologics Ltd. Long-acting coagulation factors and methods of producing same
EP3202779A2 (en) 2006-02-03 2017-08-09 OPKO Biologics Ltd. Long-acting hgh polypeptides and uses thereof
EP3663312A1 (en) 2006-02-03 2020-06-10 OPKO Biologics Ltd. Long-acting polypeptides and uses thereof
WO2007091254A1 (en) 2006-02-06 2007-08-16 Rappaport Family Institute For Research In The Medical Sciences Methods and kit for diagnosing t1dm
US9057092B2 (en) 2006-03-06 2015-06-16 Zetiq Technologies Ltd. Methods and compositions for identifying a cell phenotype
US10018622B2 (en) 2006-03-06 2018-07-10 Zetiq Technologies Ltd. Methods and kits for differential staining of abnormal urinary system cells
EP3091071A1 (en) 2006-03-23 2016-11-09 Pluristem Ltd. Methods for cell expansion and uses of cells and conditioned media produced thereby for therapy
EP2626417A1 (en) 2006-03-23 2013-08-14 Pluristem Ltd. Methods for cell expansion and uses of cells and conditioned media produced thereby for therapy
EP2548951A1 (en) 2006-03-23 2013-01-23 Pluristem Ltd. Methods for cell expansion and uses of cells and conditioned media produced thereby for therapy
EP2366775A1 (en) 2006-03-23 2011-09-21 Pluristem Ltd. Methods for cell expansion and uses of cells and conditioned media produced thereby for therapy
WO2007110869A2 (en) 2006-03-28 2007-10-04 Tel Hashomer Medical Research Infrastructure And Services Ltd. Methods and kits for determining predisposition to warfarin resistance
US20100055033A1 (en) * 2006-04-07 2010-03-04 The Government Of The United States Of America As Represented By The Secretary Antibody compositions and methods for treatment of neoplastic disease
US8071323B2 (en) 2006-04-07 2011-12-06 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Human monoclonal antibodies that bind human insulin like growth factors and their use
US20110150874A1 (en) * 2006-05-19 2011-06-23 Teva Pharmaceutical Industries Ltd. Fusion proteins, uses thereof and processes for producing same
US20070281883A1 (en) * 2006-06-05 2007-12-06 Hanna Rosenfeld Development of follicle stimulating hormone agonists and antagonists in fish
WO2008010228A2 (en) 2006-07-20 2008-01-24 Yeda Research And Development Co. Ltd. Photosyntheticorganisms and compositions and methods of generating same
WO2008026198A2 (en) 2006-08-28 2008-03-06 Yeda Research And Development Co. Ltd. Methods of generating glial and neuronal cells and use of same for the treatment of medical conditions of the cns
US20080199895A1 (en) * 2006-10-05 2008-08-21 Yeda Research And Development Co. Ltd. Highly purified and stabilized Na,K-ATPase isoforms and methods of producing same
WO2008041183A2 (en) 2006-10-05 2008-04-10 Technion Research & Development Foundation Ltd. Microtubes and methods of producing same
US20090293146A1 (en) * 2006-12-20 2009-11-26 Evogene Ltd. Polynucleotides and polypeptides involved in plant fiber development and methods of using same
EP2383345A1 (en) 2006-12-20 2011-11-02 Evogene Ltd. Polynucleotides and polypeptides involved in plant fiber development and methods of using same
US9631000B2 (en) 2006-12-20 2017-04-25 Evogene Ltd. Polynucleotides and polypeptides involved in plant fiber development and methods of using same
US8168857B2 (en) 2006-12-20 2012-05-01 Evogene Ltd. Polynucleotides and polypeptides involved in plant fiber development and methods of using same
US20100105759A1 (en) * 2007-01-16 2010-04-29 Abraham Hochberg H19 silencing nucleic acid agents for treating rheumatoid arthritis
US7928083B2 (en) 2007-01-16 2011-04-19 Yissum Research Development Company Of The Hebrew University Of Jerusalem H19 silencing nucleic acid agents for treating rheumatoid arthritis
US20100196403A1 (en) * 2007-01-29 2010-08-05 Jacob Hochman Antibody conjugates for circumventing multi-drug resistance
WO2008093341A2 (en) 2007-01-31 2008-08-07 Technion Research & Development Foundation Ltd. Electrospun scaffolds and methods of generating and using same
WO2008093342A2 (en) 2007-02-01 2008-08-07 Technion Research & Development Foundation Ltd. Albumin fibers and fabrics and methods of generating and using same
EP2478924A1 (en) 2007-02-01 2012-07-25 Technion Research & Development Foundation Albumin fibers and fabrics and methods of generating and using same
EP2839839A1 (en) 2007-02-28 2015-02-25 Yeda Research And Development Company Limited Nuclear targeting sequences
EP2514766A2 (en) 2007-03-29 2012-10-24 Technion Research & Development Foundation Ltd. Antibodies, methods and kits for diagnosing and treating melanoma
WO2008120202A2 (en) 2007-03-29 2008-10-09 Technion Research & Development Foundation Ltd. Antibodies, methods and kits for diagnosing and treating melanoma
WO2008120216A1 (en) 2007-04-02 2008-10-09 Ramot At Tel Aviv University Ltd. Methods of detecting cancer cells and use of same for diagnosing and monitoring treatment of the disease
US9487793B2 (en) 2007-04-09 2016-11-08 Evogene Ltd. Polynucleotides, polypeptides and methods for increasing oil content, growth rate and biomass of plants
US8513488B2 (en) 2007-04-09 2013-08-20 Evogene Ltd. Polynucleotides, polypeptides and methods for increasing oil content, growth rate and biomass of plants
US20100092386A1 (en) * 2007-04-23 2010-04-15 David Segev System for delivering therapeutic agents into living cells and cells nuclei
US8293209B2 (en) 2007-04-23 2012-10-23 Segev Laboratories Limited System for delivering therapeutic agents into living cells and cells nuclei
US9156865B2 (en) 2007-04-23 2015-10-13 Deliversir Ltd System for delivering therapeutic agents into living cells and cells nuclei
US9556210B2 (en) 2007-04-23 2017-01-31 Sabag-Rfa Ltd. System for delivering therapeutic agents into living cells and cells nuclei
WO2008132753A2 (en) 2007-05-01 2008-11-06 Tel Hashomer Medical Research Infrastructure And Services Ltd. Methods and kits for detecting fetal cells in the maternal blood
EP3032259A1 (en) 2007-05-01 2016-06-15 Tel Hashomer Medical Research Infrastructure and Services Ltd. Methods for detecting trophoblast cells in maternal blood based on cytokeratin-7
EP3360571A1 (en) 2007-05-03 2018-08-15 Agency For Science, Technology And Research (A*star) Antibodies binding to an intracellular prl-1 or prl-3 polypeptide
EP2529754A1 (en) 2007-05-03 2012-12-05 Agency For Science, Technology And Research (A*star) Antibodies binding to an intracellular PRL-1 or PRL-3 polypeptide
EP3366762A1 (en) 2007-05-07 2018-08-29 Protalix Ltd. Large scale disposable bioreactor
EP2500428A2 (en) 2007-07-11 2012-09-19 Yeda Research and Development Co. Ltd. Nucleic acid construct systems capable of diagnosing or treating a cell state
EP2527441A2 (en) 2007-07-15 2012-11-28 Technion Research & Development Foundation Compositions and methods for treating tumors, fibrosis, and pulmonary alveolar proteinosis
WO2009010968A2 (en) 2007-07-15 2009-01-22 Yitzchak Hillman Disease treatment via antimicrobial peptides or their inhibitors
EP3075854A1 (en) 2007-07-15 2016-10-05 Technion Research & Development Foundation Ltd. Compositions and methods for treating tumors, fibrosis, and pulmonary alveolar proteinosis
US9518267B2 (en) 2007-07-24 2016-12-13 Evogene Ltd. Polynucleotides, polypeptides encoded thereby, and methods of using same for increasing abiotic stress tolerance and/or biomass and/or yield in plants expressing same
US8686227B2 (en) 2007-07-24 2014-04-01 Evogene Ltd. Polynucleotides, polypeptides encoded thereby, and methods of using same for increasing abiotic stress tolerance and/or biomass and/or yield in plants expressing same
EP2910638A2 (en) 2007-07-24 2015-08-26 Evogene Ltd. Polynucleotides, polypeptides encoded thereby, and methods of using same for increasing abiotic stress tolerance and/or biomass and/or yield in plants expressing same
US8658167B2 (en) 2007-08-02 2014-02-25 Gilead Biologics, Inc. Methods and compositions for treatment and diagnosis of fibrosis, tumor invasion, angiogenesis, and metastasis
US20090104201A1 (en) * 2007-08-02 2009-04-23 Victoria Smith Methods and compositions for treatment and diagnosis of fibrosis, tumor invasion, angiogenesis, and metastasis
US20090053224A1 (en) * 2007-08-02 2009-02-26 Arresto Biosciences Lox and loxl2 inhibitors and uses thereof
US10494443B2 (en) 2007-08-02 2019-12-03 Gilead Biologics, Inc. LOX and LOXL2 inhibitors and uses thereof
US8461303B2 (en) 2007-08-02 2013-06-11 Gilead Biologics, Inc. LOX and LOXL2 inhibitors and uses thereof
US8679485B2 (en) 2007-08-02 2014-03-25 Gilead Biologics, Inc. Methods and compositions for treatment and diagnosis of fibrosis, tumor invasion, angiogenesis, and metastasis
US9176139B2 (en) 2007-08-02 2015-11-03 Gilead Biologics, Inc. LOX and LOXL2 inhibitors and uses thereof
EP2581445A1 (en) 2007-08-15 2013-04-17 Yeda Research And Development Co. Ltd. Regulators of MMP-9 and uses thereof
WO2009034574A2 (en) 2007-09-12 2009-03-19 Yeda Research And Development Co. Ltd. Methods of treating tumors in immune-privileged sites
EP3103463A1 (en) 2007-09-19 2016-12-14 Pluristem Ltd. Adherent cells from adipose or placenta tissues and use thereof in therapy
EP2591789A2 (en) 2007-09-19 2013-05-15 Pluristem Ltd. Adherent cells from adipose or placenta tissues and use thereof in therapy
EP2781223A1 (en) 2007-10-19 2014-09-24 Rappaport Family Institute for Research in the Medical Sciences Compositions comprising semaphorins for the treatment of angiogenesis related diseases
EP2599790A1 (en) 2007-11-26 2013-06-05 Yissum Research Development Company of The Hebrew University of Jerusalem Compositions comprising fibrous polypeptides and polysachharides
EP2071021A2 (en) 2007-12-12 2009-06-17 University of South Florida Bone marrow-derived neuronal cells
US8426682B2 (en) 2007-12-27 2013-04-23 Evogene Ltd. Isolated polypeptides, polynucleotides useful for modifying water user efficiency, fertilizer use efficiency, biotic/abiotic stress tolerance, yield and biomass in plants
US9670501B2 (en) 2007-12-27 2017-06-06 Evogene Ltd. Isolated polypeptides, polynucleotides useful for modifying water user efficiency, fertilizer use efficiency, biotic/abiotic stress tolerance, yield and biomass in plants
WO2009083958A2 (en) 2007-12-27 2009-07-09 Evogene Ltd. Isolated polypeptides, polynucleotides useful for modifying water user efficiency, fertilizer use efficiency, biotic/abiotic stress tolerance, yield and biomass in plants
US20110052501A1 (en) * 2008-01-31 2011-03-03 Liat Dassa Polypeptides and polynucleotides, and uses thereof as a drug target for producing drugs and biologics
WO2009104174A2 (en) 2008-02-21 2009-08-27 Technion Research & Development Foundation Ltd . A method of attaching a cell-of-interest to a microtube
US20110033473A1 (en) * 2008-04-09 2011-02-10 Yoram Reiter Anti influenza antibodies and uses thereof
US20110020357A1 (en) * 2008-04-09 2011-01-27 Technion Research & Development Foundation Ltd. Anti human immunodeficiency antibodies and uses thereof
US8747855B2 (en) 2008-04-09 2014-06-10 Technion Research & Development Foundation Limited Anti human immunodeficiency antibodies and uses thereof
US9132587B2 (en) 2008-04-10 2015-09-15 Stratasys Ltd. System and method for three dimensional model printing
US20110147993A1 (en) * 2008-04-10 2011-06-23 Objet Geometries Ltd. System and method for three dimensional model printing
EP3020410A1 (en) 2008-04-18 2016-05-18 Collplant Ltd. Methods of generating and using procollagen
EP2936976A1 (en) 2008-04-21 2015-10-28 Danziger Innovations Ltd. Plant viral expression vectors and use of same for generating genotypic variations in plant genomes
EP2116618A1 (en) 2008-05-09 2009-11-11 Agency for Science, Technology And Research Diagnosis and treatment of Kawasaki disease
US8847008B2 (en) 2008-05-22 2014-09-30 Evogene Ltd. Isolated polynucleotides and polypeptides and methods of using same for increasing plant utility
EP2641606A1 (en) 2008-05-27 2013-09-25 Pluristem Ltd. Methods of treating inflammatory colon diseases
EP3514229A1 (en) 2008-05-28 2019-07-24 Ramot at Tel-Aviv University Ltd. Mesenchymal stem cells for the treatment of cns diseases
EP2620493A1 (en) 2008-05-28 2013-07-31 Ramot at Tel Aviv University Ltd. Mesenchymal stem cells for the treatment of CNS diseases
US11280785B2 (en) 2008-06-29 2022-03-22 Realbio Technologies Ltd. Liquid-transfer device particularly useful as a capturing device in a biological assay process
US9952211B2 (en) 2008-06-29 2018-04-24 Realbio Technologies Ltd. Liquid-transfer device particularly useful as a capturing device in a biological assay process
EP2657342A1 (en) 2008-08-08 2013-10-30 Genisphere Inc. DNA dendrimers protected against nuclease degradation are useful as vectors for the delivery of siRNA
WO2010016806A1 (en) 2008-08-08 2010-02-11 Agency For Science, Technology And Research (A*Star) Vhz for diagnosis and treatment of cancers
WO2010017544A2 (en) 2008-08-08 2010-02-11 Genisphere, Inc. Long-acting dna dendrimers and methods thereof
EP3072972A2 (en) 2008-08-18 2016-09-28 Evogene Ltd. Isolated polypeptides and polynucleotides useful for increasing nitrogen use efficiency, abiotic stress tolerance, yield and biomass in plants
EP3616504A2 (en) 2008-08-18 2020-03-04 Evogene Ltd. Isolated polypeptides and polynucleotides useful for increasing nitrogen use efficiency, abiotic stress tolerance, yield and biomass in plants
US9018445B2 (en) 2008-08-18 2015-04-28 Evogene Ltd. Use of CAD genes to increase nitrogen use efficiency and low nitrogen tolerance to a plant
EP3115451A1 (en) 2008-09-02 2017-01-11 Pluristem Ltd. Adherent cells from placenta tissue and use thereof in therapy
US20100081177A1 (en) * 2008-09-05 2010-04-01 TransAlgae Ltd Decreasing RUBISCO content of algae and cyanobacteria cultivated in high carbon dioxide
US8367392B2 (en) 2008-09-05 2013-02-05 Transalgae Ltd. Genetic transformation of algal and cyanobacteria cells by microporation
WO2010029545A2 (en) 2008-09-11 2010-03-18 Ben Gurion University Of The Negev Research And Development Authority Compositions and methods for treating s. pneumoniae infection
WO2010031006A1 (en) 2008-09-12 2010-03-18 Cryopraxis Criobiologia Ltda. Ischemic tissue cell therapy
EP3670524A1 (en) 2008-09-24 2020-06-24 Tel HaShomer Medical Research Infrastructure and Services Ltd. Peptides and compositions for prevention of cell adhesion and methods of using same
EP2789626A2 (en) 2008-09-24 2014-10-15 Tel Hashomer Medical Research Infrastructure and Services Ltd. Peptides and compositions for prevention of cell adhesion and methods of using same
WO2010035261A2 (en) 2008-09-29 2010-04-01 Ben Gurion University Of The Negev Research And Development Authority Amyloid beta-peptides and methods of use thereof
WO2010049897A2 (en) 2008-10-30 2010-05-06 Evogene Ltd. Isolated polynucleotides and polypeptides and methods of using same for increasing plant yield, biomass, growth rate, vigor, oil content, abiotic stress tolerance of plants and nitrogen use efficieny
US20110197315A1 (en) * 2008-10-30 2011-08-11 Evogene Ltd. Isolated polynucleotides and polypeptides and methods of using same for increasing plant yield
US8921658B2 (en) 2008-10-30 2014-12-30 Evogene Ltd. Isolated polynucleotides encoding a MAP65 polypeptide and methods of using same for increasing plant yield
WO2010055525A1 (en) 2008-11-17 2010-05-20 Technion Research & Development Foundation Ltd. Method for predicting a patient's responsiveness to anti-folate therapy
WO2010058396A1 (en) 2008-11-19 2010-05-27 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. A cd44vra antibody and diagnostic and therapeutic methods using same
WO2010061383A1 (en) 2008-11-26 2010-06-03 Biodalia Microbiological Technologies Ltd. A method of in-situ enrichment of foods with fructan
WO2010064231A1 (en) 2008-12-02 2010-06-10 Tel Hashomer Medical Research Infrastructure And Services Ltd. Methods of analyzing a-i rna editing and nucleic acid constructs capable of same
WO2010064247A1 (en) 2008-12-03 2010-06-10 Tel Hashomer Medical Research Infrastructure And Services Ltd. Methods and kits for determining predisposition to cancer
EP2633854A1 (en) 2008-12-05 2013-09-04 Yeda Research And Development Co. Ltd. miRNA-9 or miRNA-9* for use in treating MND
WO2010071610A1 (en) 2008-12-19 2010-06-24 Agency For Science, Technology And Research (A*Star) Severe chikungunya biomarkers
WO2010076756A2 (en) 2008-12-29 2010-07-08 Evogene Ltd. Polynucleotides, polypeptides encoded thereby, and methods of using same for increasing abiotic stress tolerance, biomass and/or yield in plants expressing same
WO2010076788A2 (en) 2008-12-29 2010-07-08 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Methods of predicting responsiveness to interferon treatment and treating hepatitis c infection
WO2010076642A1 (en) 2008-12-29 2010-07-08 Tel Hashomer Medical Research, Infrastructure And Services Ltd Peptides and compositions for prevention of cell adhesion and methods of using same
EP2808402A2 (en) 2008-12-29 2014-12-03 Yissum Research Development Company of the Hebrew University of Jerusalem Ltd. Methods of predicting responsiveness to interferon treatment
WO2010076794A1 (en) 2008-12-31 2010-07-08 Technion Research & Development Foundation Ltd. Method of denitrifying brine and systems capable of same
US9107935B2 (en) 2009-01-06 2015-08-18 Gilead Biologics, Inc. Chemotherapeutic methods and compositions
US9289447B2 (en) 2009-01-06 2016-03-22 Gilead Biologics, Inc. Chemotherapeutic methods and compositions
WO2010086856A2 (en) 2009-02-01 2010-08-05 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Methods of generating tissue using devitalized, acellular scaffold matrices derived from micro-organs
US10093896B2 (en) 2009-02-01 2018-10-09 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Methods of generating tissue using devitalized, acellular scaffold matrices derived from micro-organs
WO2010086867A2 (en) 2009-02-02 2010-08-05 Ramot At Tel Aviv University Ltd. Peptides, pharmaceutical compositions comprising same and uses thereof
WO2010089707A1 (en) 2009-02-04 2010-08-12 Yeda Research And Development Co. Ltd. Methods and kits for determining sensitivity or resistance of prostate cancer to radiation therapy
WO2010097793A2 (en) 2009-02-26 2010-09-02 Tel Hashomer Medical Research Infrastructure And Services Ltd. Isolated populations of renal stem cells and methods of isolating and using same
EP2465920A2 (en) 2009-02-26 2012-06-20 Tel HaShomer Medical Research Infrastructure and Services Ltd. Isolated populations of renal stem cells and methods of isolating and using same
WO2010097794A1 (en) 2009-02-26 2010-09-02 Tel Hashomer Medical Research Infrastructure And Services Ltd. Methods of reprogramming renal cells
WO2010100595A2 (en) 2009-03-02 2010-09-10 Evogene Ltd. Isolated polynucleotides and polypeptides, and methods of using same for increasing plant yield and/or agricultural characteristics
EP3000889A2 (en) 2009-03-02 2016-03-30 Evogene Ltd. Isolated polynucleotides and polypeptides, and methods of using same for increasing plant yield and/or agricultural characteristics
US8937220B2 (en) 2009-03-02 2015-01-20 Evogene Ltd. Isolated polynucleotides and polypeptides, and methods of using same for increasing plant yield, biomass, vigor and/or growth rate of a plant
EP3026057A2 (en) 2009-03-09 2016-06-01 Ramot at Tel Aviv University Ltd. Compositions for prevention and treatment of neurodegenerative diseases
WO2010103517A1 (en) 2009-03-12 2010-09-16 Rappaport Family Institute For Research In The Medical Sciences Soluble compositions for the treatment of cxcr3-ligand associated diseases
WO2010113096A1 (en) 2009-03-30 2010-10-07 Tel Hashomer Medical Research Infrastructure And Services Ltd. Methods of predicting clinical course and treating multiple sclerosis
WO2010113146A1 (en) 2009-04-01 2010-10-07 The Medical Research, Infrastructure, And Health Services Fund Of The Tel Aviv Medical Center A method of regulating proliferation and differentiation of keratinocyes
WO2010116375A1 (en) 2009-04-08 2010-10-14 Yeda Research And Development Co. Ltd. Isolated peptides for regulating apoptosis
EP2990421A1 (en) 2009-04-30 2016-03-02 Tel HaShomer Medical Research Infrastructure and Services Ltd. Anti ceacam1 antibodies and methods of using same
US9182403B2 (en) 2009-05-19 2015-11-10 Zetiq Technologies Ltd. Kits for and methods of differential staining of cervical cancer cells and/or tissues
WO2010137013A1 (en) 2009-05-27 2010-12-02 Ramot At Tel Aviv University Ltd. Crystallized photosystem i units from the pea plant and their use in solid state devices
WO2010137021A2 (en) 2009-05-27 2010-12-02 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Method of generating connective tissue
WO2010137017A2 (en) 2009-05-27 2010-12-02 Yeda Research And Development Co. Ltd. Proteasome inhibitors and uses thereof
WO2010137020A1 (en) 2009-05-28 2010-12-02 Yeda Research And Development Co. Ltd. Methods of treating inflammation
EP3626051A2 (en) 2009-06-10 2020-03-25 Evogene Ltd. Isolated polynucleotides and polypeptides, and methods of using same for increasing nitrogen use efficiency, yield, growth rate, vigor, biomass, oil content, and/or abiotic stress tolerance
EP3238534A2 (en) 2009-06-10 2017-11-01 Evogene Ltd. Isolated polynucleotides and polypeptides, and methods of using same for increasing nitrogen use efficiency, yield, growth rate, vigor, biomass, oil content, and/or abiotic stress tolerance
US9096865B2 (en) 2009-06-10 2015-08-04 Evogene Ltd. Isolated polynucleotides and polypeptides, and methods of using same for increasing nitrogen use efficiency, yield, growth rate, vigor, biomass, oil content, and/or abiotic stress tolerance
WO2010150259A1 (en) 2009-06-24 2010-12-29 Fund For Medical Research Development Of Infrastructure And Health Services -Rambam Medical Center Methods and kits for isolating placental derived microparticles and use of same for diagnosis of fetal disorders
WO2011004361A2 (en) 2009-07-09 2011-01-13 Prolor Biotech Inc. Long-acting coagulation factors and methods of producing same
US10538755B2 (en) 2009-07-09 2020-01-21 Opko Biologics Ltd. Long-acting coagulation factors and methods of producing same
EP3130346A1 (en) 2009-07-09 2017-02-15 OPKO Biologics Ltd. Long-acting factor vii coagulation factors
US9663778B2 (en) 2009-07-09 2017-05-30 OPKO Biologies Ltd. Long-acting coagulation factors and methods of producing same
WO2011004379A1 (en) 2009-07-10 2011-01-13 Tel Hashomer Medical Research Infrastructure And Services Ltd. Compositions and methods for treating cancer
WO2011010309A1 (en) 2009-07-21 2011-01-27 Tel Hashomer Medical Research Infrastructure And Services Ltd. A method of diagnosing cancer
US9574210B2 (en) 2009-07-31 2017-02-21 Ramot At Tel-Aviv University Ltd. Cell-targeting nanoparticles comprising polynucleotide agents and uses thereof
WO2011013130A2 (en) 2009-07-31 2011-02-03 Ramot At Tel-Aviv University Ltd. Cell-targeting nanoparticles comprising polynucleotide agents and uses thereof
US10179113B2 (en) 2009-07-31 2019-01-15 Ramot At Tel-Aviv University Ltd. Cell-targeting nanoparticles comprising polynucleotide agents and uses thereof
WO2011021194A2 (en) 2009-08-17 2011-02-24 Technion Research & Development Foundation Ltd. Pericyte progenitor cells and methods of generating and using same
WO2011021171A1 (en) 2009-08-21 2011-02-24 Beeologics, Llc Preventing and curing beneficial insect diseases via plant transcribed molecules
US8927700B2 (en) 2009-08-21 2015-01-06 Gilead Biologics, Inc. Catalytic domains from lysyl oxidase and LOXL2
US8512990B2 (en) 2009-08-21 2013-08-20 Gilead Biologics, Inc. Catalytic domains from lysyl oxidase and LOXL2
US20110207144A1 (en) * 2009-08-21 2011-08-25 Derek Marshall In vitro screening assays
WO2011024172A2 (en) 2009-08-27 2011-03-03 Technion Research & Development Foundation Ltd. Liposomal compositions and uses of same
WO2011030336A1 (en) 2009-09-08 2011-03-17 Ramot At Tel-Aviv University Ltd. Methods of diagnosing amyotrophic lateral sclerosis (als)
WO2011030332A2 (en) 2009-09-08 2011-03-17 Yeda Research And Development Co. Ltd. Methods for hematopoietic precursor mobilization
WO2011030329A1 (en) 2009-09-10 2011-03-17 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Method of treating tumors
WO2011033506A2 (en) 2009-09-17 2011-03-24 Yeda Research And Development Co. Ltd. Isolated pon1 polypeptides, polynucleotides encoding same and uses thereof in treating or preventing organophosphate exposure associated damage
WO2011033511A1 (en) 2009-09-17 2011-03-24 Ramot At Tel-Aviv University Ltd. Peptides for the treatment of oxidative stress related disorders
US20110081706A1 (en) * 2009-10-02 2011-04-07 TransAlgae Ltd Method and system for efficient harvesting of microalgae and cyanobacteria
WO2011045796A1 (en) 2009-10-14 2011-04-21 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Compositions for controlling varroa mites in bees
US10801028B2 (en) 2009-10-14 2020-10-13 Beeologics Inc. Compositions for controlling Varroa mites in bees
EP3272869A1 (en) 2009-10-14 2018-01-24 Yissum Research Development Company of The Hebrew University of Jerusalem Ltd. Compositions for controlling varroa mites in bees
WO2011046570A1 (en) 2009-10-16 2011-04-21 The University Of Medicine And Dentistry Of New Jersey Method for treating chronic nerve tissue injury using a cell therapy strategy
WO2011048600A1 (en) 2009-10-21 2011-04-28 Danziger Innovations Ltd. Generating genotypic variations in plant genomes by gamete infection
WO2011055366A1 (en) 2009-11-08 2011-05-12 Medical Research & Development Fund For Health Services Bnai Zion Medical Center, The State Of Israel Mo-1 conditional knock-out non-human animal and uses thereof
WO2011058557A1 (en) 2009-11-12 2011-05-19 Ramot At Tel-Aviv University Ltd. Compositions comprising pedf and uses of same in the treatment and prevention of ovary-related syndromes
WO2011058555A1 (en) 2009-11-12 2011-05-19 Yeda Research And Development Co. Ltd. A method of editing dna in a cell and constructs capable of same
EP3633025A1 (en) 2009-11-12 2020-04-08 Technion Research & Development Foundation Ltd. Culture media, cell cultures and methods of culturing pluripotent stem cells in an undifferentiated state
EP4166652A1 (en) 2009-11-12 2023-04-19 Technion Research & Development Foundation Ltd. Culture media, cell cultures and methods of culturing pluripotent stem cells in an undifferentiated state
WO2011061736A1 (en) 2009-11-17 2011-05-26 Protalix Ltd. Alkaline alpha galactosidase for the treatment of fabry disease
WO2011064773A1 (en) 2009-11-24 2011-06-03 Collplant Ltd. Method of generating collagen fibers
EP2977445A2 (en) 2009-11-30 2016-01-27 Pluristem Ltd. Adherent cells from placenta and use of same in disease treatment
WO2011064669A2 (en) 2009-11-30 2011-06-03 Pluristem Ltd. Adherent cells from placenta and use of same in disease treatment
EP2806023A2 (en) 2009-11-30 2014-11-26 Pluristem Ltd. Adherent cells from placenta and use of same in disease treatment
WO2011067745A2 (en) 2009-12-06 2011-06-09 Rosetta Green Ltd. Compositions and methods for enhancing plants resistance to abiotic stress
US9562235B2 (en) 2009-12-06 2017-02-07 A.B. Seeds Ltd. MicroRNA compositions and methods for enhancing plant resistance to abiotic stress
WO2011072091A1 (en) 2009-12-09 2011-06-16 Quark Pharmaceuticals, Inc. Methods and compositions for treating diseases, disorders or injury of the cns
EP2862929A1 (en) 2009-12-09 2015-04-22 Quark Pharmaceuticals, Inc. Compositions and methods for treating diseases, disorders or injury of the CNS
WO2011080674A2 (en) 2009-12-28 2011-07-07 Evogene Ltd. Isolated polynucleotides and polypeptides and methods of using same for increasing plant yield, biomass, growth rate, vigor, oil content, abiotic stress tolerance of plants and nitrogen use efficiency
EP3056569A2 (en) 2009-12-28 2016-08-17 Evogene Ltd. Isolated polynucleotides and polypeptides and methods of using same for increasing plant yield, biomass, growth rate, vigor, oil content, abiotic stress tolerance of plants and nitrogen use efficiency
US9493785B2 (en) 2009-12-28 2016-11-15 Evogene Ltd. Isolated polynucleotides and polypeptides and methods of using same for increasing plant yield, biomass, growth rate, vigor, oil content, abiotic stress tolerance of plants and nitrogen use efficiency
EP3184109A1 (en) 2009-12-29 2017-06-28 Gamida-Cell Ltd. Methods for enhancing natural killer cell proliferation and activity
EP3785712A1 (en) 2009-12-29 2021-03-03 Gamida-Cell Ltd. Methods for enhancing natural killer cell proliferation and activity
WO2011080740A1 (en) 2009-12-29 2011-07-07 Gamida-Cell Ltd. Methods for enhancing natural killer cell proliferation and activity
EP3159405A1 (en) 2010-01-05 2017-04-26 Vascular Biogenics Ltd. Methods for use of a specific anti-angiogenic adenoviral agent
WO2011086509A1 (en) 2010-01-12 2011-07-21 Vascular Biogenics Ltd. Methods of producing adenovirus vectors and viral preparations generated thereby
WO2011092700A1 (en) 2010-01-27 2011-08-04 Yeda Research And Development Co. Ltd. Antibodies that inhibit metalloproteins
EP3216805A1 (en) 2010-01-27 2017-09-13 Yeda Research and Development Co. Ltd Antibodies that inhibit metalloproteins
US8680246B2 (en) 2010-02-04 2014-03-25 Gilead Biologics, Inc. Antibodies that bind to lysyl oxidase-like 2 (LOXL2)
WO2011099006A2 (en) 2010-02-11 2011-08-18 Yeda Research And Development Co. Ltd. Enzymatic systems for carbon fixation and methods of generating same
WO2011104708A2 (en) 2010-02-24 2011-09-01 Ben Gurion University Of The Negev Research And Development Authority Methods for inhibiting necrosis
WO2011107939A1 (en) 2010-03-01 2011-09-09 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Methods of predicting efficacy of an anti-vegfa treatment for solid tumors
WO2011107994A1 (en) 2010-03-04 2011-09-09 Yeda Research And Development Co. Ltd. Methods of measuring protein stability
WO2011111034A1 (en) 2010-03-08 2011-09-15 Yeda Research And Development Co. Ltd. Recombinant protein production in heterologous systems
US9121022B2 (en) 2010-03-08 2015-09-01 Monsanto Technology Llc Method for controlling herbicide-resistant plants
US9988634B2 (en) 2010-03-08 2018-06-05 Monsanto Technology Llc Polynucleotide molecules for gene regulation in plants
US11812738B2 (en) 2010-03-08 2023-11-14 Monsanto Technology Llc Polynucleotide molecules for gene regulation in plants
WO2011111050A2 (en) 2010-03-11 2011-09-15 Jacob Edrei Methods of generating hydrogen
WO2011125015A2 (en) 2010-04-05 2011-10-13 Bar-Ilan University Protease-activatable pore-forming polypeptides
US9458438B2 (en) 2010-04-12 2016-10-04 Ben Gurion University Of The Negev Research And Development Authority Sulfotransferase of a red microalga and uses thereof
WO2011128897A1 (en) 2010-04-12 2011-10-20 Technion Research & Development Foundation Ltd. Populations of pancreatic progenitor cells and methods of isolating and using same
WO2011132182A1 (en) 2010-04-18 2011-10-27 Yeda Research And Development Co. Ltd. MOLECULES AND METHODS OF USING SAME FOR TREATING ErbB/ErbB LIGANDS ASSOCIATED DISEASES
WO2011135527A2 (en) 2010-04-28 2011-11-03 Evogene Ltd. Isolated polynucleotides and polypeptides, and methods of using same for increasing plant yield and/or agricultural characteristics
US9328353B2 (en) 2010-04-28 2016-05-03 Evogene Ltd. Isolated polynucleotides and polypeptides for increasing plant yield and/or agricultural characteristics
WO2011138778A2 (en) 2010-05-04 2011-11-10 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Methods of identifying inhibitors of polypeptides-of-interest
WO2011138785A2 (en) 2010-05-05 2011-11-10 Rappaport Family Institute For Research In The Medical Sciences Use of ccl1 in therapy
WO2011138776A2 (en) 2010-05-06 2011-11-10 Hervana Ltd. Biologic female contraceptives
WO2011141914A1 (en) 2010-05-13 2011-11-17 Tel Hashomer Medical Research Infrastructure And Services Ltd. Isolated populations of adult renal cells and methods of isolating and using same
WO2011147563A1 (en) 2010-05-25 2011-12-01 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Method for electrochemically detecting binding reactions
EP2390664A1 (en) 2010-05-25 2011-11-30 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Method for electrochemical detection of binding reactions
US8945852B2 (en) 2010-05-25 2015-02-03 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e. V. Method for electrochemical detection of binding reactions
US8945943B2 (en) 2010-05-26 2015-02-03 The Board Of Trustees Of The University Of Illinois Personal glucose meters for detection and quantification of a broad range of analytes
WO2011150186A1 (en) * 2010-05-26 2011-12-01 The Board Of Trustees Of The University Of Illinois Personal glucose meters for detection and quantification of a broad range of analytes
WO2011151833A1 (en) 2010-06-03 2011-12-08 Ramot At Tel-Aviv University Ltd. Methods of treating diabetes and compositions capable of same
WO2011154940A1 (en) 2010-06-07 2011-12-15 Osnat Ashur-Fabian Methods and kits for diagnosing conditions related to hypoxia
WO2011158243A2 (en) 2010-06-16 2011-12-22 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Method of diagnosing and treating cancer
WO2011158242A2 (en) 2010-06-16 2011-12-22 Futuragene Israel Ltd. Pest -resistant plants containing a combination of a spider toxin and a chitinase
WO2012007945A2 (en) 2010-07-12 2012-01-19 The State Of Israel, Ministry Of Agriculture & Rural Development, Agricultural Research Organization, (A.R.O.), Volcani Center Isolated polynucleotides and methods and plants using same for regulating plant acidity
WO2012007951A1 (en) 2010-07-15 2012-01-19 Technion Research & Development Foundation Ltd. Isolated high affinity entities with t-cell receptor like specificity towards native complexes of mhc class ii and glutamic acid decarboxylase (gad) autoantigenic peptides
WO2012007919A2 (en) 2010-07-15 2012-01-19 Technion Research & Development Foundation Ltd. Nucleic acid construct for increasing abiotic stress tolerance in plants
WO2012007950A2 (en) 2010-07-15 2012-01-19 Technion Research & Development Foundation Ltd. Isolated high affinity entities with t-cell receptor like specificity towards native complexes of mhc class ii and diabetes-associated autoantigenic peptides
WO2012011113A2 (en) 2010-07-22 2012-01-26 Shai Yarkoni Regulatory immune cells with enhanced targeted cell death effect
WO2012014208A2 (en) 2010-07-27 2012-02-02 Yeda Research And Development Co. Ltd. Methods and systems for assessing clonality of cell cultures
WO2012014207A2 (en) 2010-07-27 2012-02-02 Technion Research & Development Foundation Ltd. Method for generating induced pluripotent stem cells from keratinocytes derived from plucked hair follicles
WO2012014205A1 (en) 2010-07-27 2012-02-02 Technion Research & Development Foundation Ltd. Isolated mesenchymal progenitor cells and extracellular matrix produced thereby
WO2012017439A2 (en) 2010-08-04 2012-02-09 Ramot At Tel-Aviv University Ltd. Methods of treating autoimmune diseases of the central nervous system (cns) and neurodegenerative diseases
WO2012025914A1 (en) 2010-08-22 2012-03-01 Ramot At Tel-Aviv University Ltd. Induced pluripotent stem cells derived from human pancreatic beta cells
WO2012025925A1 (en) 2010-08-24 2012-03-01 Rappaport Family Institute For Research In The Medical Sciences Methods of improving transplantation using sdf-1alpha
US10457954B2 (en) 2010-08-30 2019-10-29 Evogene Ltd. Isolated polynucleotides and polypeptides, and methods of using same for increasing nitrogen use efficiency, yield, growth rate, vigor, biomass, oil content, and/or abiotic stress tolerance
WO2012032521A2 (en) 2010-09-07 2012-03-15 Technion Research & Development Foundation Ltd. Novel methods and culture media for culturing pluripotent stem cells
WO2012032519A2 (en) 2010-09-07 2012-03-15 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Methods of diagnosing parkinson's disease
WO2012032510A1 (en) 2010-09-07 2012-03-15 Yeda Research And Development Co. Ltd. Primers for amplifying dna and methods of selecting same
WO2012032520A1 (en) 2010-09-07 2012-03-15 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Readthrough acetylcholinesterase (ache-r) for treating or preventing parkinson's disease
WO2012032525A2 (en) 2010-09-08 2012-03-15 Yeda Research And Development Co. Ltd. An immunosuppressive drug combination for a stable and long term engraftment
WO2012032526A2 (en) 2010-09-08 2012-03-15 Yeda Research And Development Co. Ltd. Use of anti third party central memory t cells for anti-leukemia/lymphoma treatment
WO2012035539A1 (en) 2010-09-15 2012-03-22 Ramot At Tel-Aviv University Ltd. Methods of expanding and redifferentiating islet beta cells
WO2012038956A1 (en) 2010-09-20 2012-03-29 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Method of treating neurodegenerative diseases
EP3075396A1 (en) 2010-10-17 2016-10-05 Yeda Research and Development Co. Ltd. Methods and compositions for the treatment of insulin-associated medical conditions
WO2012052872A2 (en) 2010-10-17 2012-04-26 Yeda Research And Development Co. Ltd. Methods and compositions for the treatment of insulin-associated medical conditions
WO2012052878A1 (en) 2010-10-19 2012-04-26 Vascular Biogenics Ltd. Isolated polynucleotides and nucleic acid constructs for directing expression of a gene-of-interest in cells
WO2012056452A2 (en) 2010-10-27 2012-05-03 Nanocyte (Israel) Ltd. Pharmaceutical compositions and delivery devices comprising stinging cells or capsules
WO2012056455A1 (en) 2010-10-28 2012-05-03 Yeda Research And Development Co. Ltd. Methods of generating antibodies to metalloenzymes
WO2012059922A2 (en) 2010-11-03 2012-05-10 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Transgenic plants with improved saccharification yields and methods of generating same
WO2012059925A2 (en) 2010-11-04 2012-05-10 Ben-Gurion University Of The Negev Research And Development Authority Acyl-coa: diacylglycerol acyltransferase 1-like gene (ptdgat1) and uses thereof
US9096645B2 (en) 2010-11-15 2015-08-04 Ramot At Tel-Aviv University Ltd. Dipeptide analogs for treating conditions associated with amyloid fibril formation
US9630989B2 (en) 2010-11-15 2017-04-25 Ramot At Tel-Aviv University Ltd. Dipeptide analogs for treating conditions associated with amyloid fibril formation
WO2012066495A2 (en) 2010-11-17 2012-05-24 Ben Gurion University Of The Negev Research And Development Authority T-cell therapy to neurodegenerative diseases
WO2012073238A1 (en) 2010-12-02 2012-06-07 Technion Research & Development Foundation Ltd. Methods of generating corneal cells and cell populations comprising same
EP2463382A1 (en) 2010-12-07 2012-06-13 Enterologics, Inc. Method for identifying E. Coli M-17
WO2012081029A1 (en) 2010-12-15 2012-06-21 Kadimastem Ltd. Insulin producing cells derived from pluripotent stem cells
US9551006B2 (en) 2010-12-22 2017-01-24 Evogene Ltd. Isolated polynucleotides and polypeptides, and methods of using same for improving plant properties
WO2012090205A2 (en) 2010-12-28 2012-07-05 Kamedis Ltd. Plant extracts for the treatment and prevention of infections
WO2012098537A1 (en) 2011-01-20 2012-07-26 Protalix Ltd. Nucleic acid construct for expression of alpha-galactosidase in plants and plant cells
WO2012104851A1 (en) 2011-01-31 2012-08-09 Yeda Research And Development Co. Ltd. Methods of diagnosing disease using overlap extension pcr
WO2012114339A1 (en) 2011-02-23 2012-08-30 Rappaport Family Institute For Research In The Medical Sciences High affinity molecules capable of binding a type a plexin receptor and uses of same
WO2012117406A2 (en) 2011-03-02 2012-09-07 Futuragene Israel Ltd. Bacterial resistant transgenic plants
WO2012117373A1 (en) 2011-03-03 2012-09-07 Ramot At Tel-Aviv University Ltd. Genetically modified muscle cells which express neurotrophic factors
WO2012120500A2 (en) 2011-03-06 2012-09-13 Merck Serono S.A. Low fucose cell lines and uses thereof
WO2012120518A1 (en) 2011-03-08 2012-09-13 Ramot At Tel-Aviv University Ltd. Compositions and methods for diagnosing and treating phenylketonuria (pku)
WO2012123938A1 (en) 2011-03-17 2012-09-20 Tel Hashomer Medical Research Infrastructure And Services Ltd. Quinolone analogs for treating autoimmune diseases
WO2012123949A1 (en) 2011-03-17 2012-09-20 Ramot At Tel-Aviv University Ltd. Bi- and monospecific, asymmetric antibodies and methods of generating the same
WO2012127320A1 (en) 2011-03-22 2012-09-27 Pluristem Ltd. Methods for treating radiation or chemical injury
EP3260533A1 (en) 2011-03-22 2017-12-27 Pluristem Ltd. Methods for treating radiation or chemical injury
WO2012127475A1 (en) 2011-03-24 2012-09-27 Neurim Pharmaceuticals (1991) Ltd. Neuroprotective peptides
WO2012131680A2 (en) 2011-03-28 2012-10-04 Yeda Research And Development Co. Ltd. Compositions and methods for treating inflammation
WO2012137202A1 (en) 2011-04-05 2012-10-11 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Composition comprising an iron indicator attached to a microparticle and uses of same for quantifying non-transferrin bound iron (ntbi) and cellular labile iron (lci)
WO2012137207A1 (en) 2011-04-06 2012-10-11 Ramot At Tel-Aviv University Ltd. Methods of monitoring and analyzing metabolic activity profiles diagnostic and therapeutic uses of same
US9676846B2 (en) 2011-04-12 2017-06-13 The United States Of America As Represented By The Secretary, Department Of Health And Human Services Human monoclonal antibodies that bind insulin-like growth factor (IGF) I and II
US9150644B2 (en) 2011-04-12 2015-10-06 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Human monoclonal antibodies that bind insulin-like growth factor (IGF) I and II
WO2012140519A2 (en) 2011-04-15 2012-10-18 Pluristem Ltd. Methods and systems for harvesting cells
US10760088B2 (en) 2011-05-03 2020-09-01 Evogene Ltd. Isolated polynucleotides and polypeptides and methods of using same for increasing plant yield, biomass, growth rate, vigor, oil content, abiotic stress tolerance of plants and nitrogen use efficiency
WO2012150600A2 (en) 2011-05-04 2012-11-08 Ramot At Tel-Aviv University Ltd. Regulation of amyloid beta molecular composition for the treatment of alzheimer's disease
WO2012153333A1 (en) 2011-05-09 2012-11-15 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Regeneration and repair of mesenchymal tissue using amelogenin
WO2012153336A2 (en) 2011-05-12 2012-11-15 Rakuto Bio Technologies Ltd. Methods and device for lightening skin complexion
WO2012156976A1 (en) 2011-05-16 2012-11-22 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Methods of producing artemisinin in non-host plants and vectors for use in same
EP3263127A1 (en) 2011-05-23 2018-01-03 Yeda Research and Development Co. Ltd Use of akt phosphorylation as a biomarker for prognosing neurodegenerative diseases and treating same
WO2012160526A2 (en) 2011-05-23 2012-11-29 Ofir Menashe Formulations of microorganism comprising particles and uses of same
WO2012164380A2 (en) 2011-05-31 2012-12-06 Hutchison Biofilm Medical Solutions Limited Dispersion and detachment of cell aggregates
EP3527581A2 (en) 2011-05-31 2019-08-21 Hutchison Biofilm Medical Solutions Limited Dispersion and detachment of cell aggregates
WO2012164565A1 (en) 2011-06-01 2012-12-06 Yeda Research And Development Co. Ltd. Compositions and methods for downregulating prokaryotic genes
US10166295B2 (en) 2011-06-02 2019-01-01 Opko Biologics Ltd. Pegylated OXM variants
WO2012172555A1 (en) 2011-06-14 2012-12-20 Yeda Research And Development Co. Ltd. Combination therapy to prevent dcis formation and progression to breast cancer
WO2012176203A1 (en) 2011-06-23 2012-12-27 Kaiima Bio Agritech Ltd. Common wheat, plants or parts thereof having partially or fully multiplied genome, hybrids and products thereof and methods of generating and using same
WO2013011507A1 (en) 2011-07-20 2013-01-24 Kaiima Bio Agritech Ltd. Maize plants having a partially or fully multiplied genome and uses thereof
EP2550982A1 (en) 2011-07-27 2013-01-30 Technion Research & Development Foundation Ltd. Devices for surgical applications
EP3482765A1 (en) 2011-08-02 2019-05-15 OPKO Biologics Ltd. Long-acting growth hormone and methods of producing same
WO2013018098A2 (en) 2011-08-02 2013-02-07 Prolor Biotech Ltd. Long-acting growth hormone and methods of producing same
EP3524679A1 (en) 2011-08-04 2019-08-14 Yeda Research and Development Co., Ltd. Micro-rna mir-19 and compositions comprising same for the treatment of medical conditions in which low adrenaline or noradrenaline level is therapeutically beneficial
WO2013018060A2 (en) 2011-08-04 2013-02-07 Yeda Research And Development Co. Ltd. Micro-rnas and compositions comprising same for the treatment and diagnosis of serotonin-, adrenalin-, noradrenalin-, glutamate-, and corticotropin-releasing hormone- associated medical conditions
EP3208338A1 (en) 2011-08-04 2017-08-23 Yeda Research and Development Co., Ltd. Micro-rna mir-15 and compositions comprising same for the treatment of corticotropin-releasing hormone- associated medical conditions
WO2013021389A2 (en) 2011-08-09 2013-02-14 Yeda Research And Development Co.Ltd. Downregulation of mir-7 for promotion of beta cell differentiation and insulin production
WO2013024481A1 (en) 2011-08-14 2013-02-21 Kaiima Bio Agritech Ltd. Durum wheat plants having a partially or fully multiplied genome and uses thereof
WO2013035070A1 (en) 2011-09-07 2013-03-14 Yeda Research And Development Co. Ltd. Olfactory signature and odorant mixture having the same
WO2013035099A1 (en) 2011-09-08 2013-03-14 Yeda Research And Development Co. Ltd. Anti third party central memory t cells, methods of producing same and use of same in transplantation and disease treatment
WO2013035071A1 (en) 2011-09-08 2013-03-14 Yeda Research And Development Co. Ltd. Novel risk biomarkers for lung cancer
US10760086B2 (en) 2011-09-13 2020-09-01 Monsanto Technology Llc Methods and compositions for weed control
US9416363B2 (en) 2011-09-13 2016-08-16 Monsanto Technology Llc Methods and compositions for weed control
US10806146B2 (en) 2011-09-13 2020-10-20 Monsanto Technology Llc Methods and compositions for weed control
US10808249B2 (en) 2011-09-13 2020-10-20 Monsanto Technology Llc Methods and compositions for weed control
US9422558B2 (en) 2011-09-13 2016-08-23 Monsanto Technology Llc Methods and compositions for weed control
US10829828B2 (en) 2011-09-13 2020-11-10 Monsanto Technology Llc Methods and compositions for weed control
US9422557B2 (en) 2011-09-13 2016-08-23 Monsanto Technology Llc Methods and compositions for weed control
US11891453B2 (en) 2011-10-11 2024-02-06 Famewave Ltd. Antibodies to carcinoembryonic antigen-related cell adhesion molecule (CEACAM)
EP3360899A1 (en) 2011-10-11 2018-08-15 Tel HaShomer Medical Research Infrastructure and Services Ltd. Antibodies to carcinoembryonic antigen-related cell adhesion molecule (ceacam)
US9771431B2 (en) 2011-10-11 2017-09-26 Ccam Biotherapeutics Ltd. Antibodies to carcinoembryonic antigen-related cell adhesion molecule (CEACAM)
WO2013054331A1 (en) 2011-10-11 2013-04-18 Tel Hashomer Medical Research Infrastructure And Services Ltd. Antibodies to carcinoembryonic antigen-related cell adhesion molecule (ceacam)
WO2013056377A1 (en) 2011-10-21 2013-04-25 Augurex Life Sciences Corporation Antigens derived from citrullinated 14-3-3 and uses thereof in the diagnosis of rheumatoid arthritis
WO2013061328A2 (en) 2011-10-27 2013-05-02 Yeda Research And Development Co. Ltd. Method of treating cancer
WO2013067076A2 (en) 2011-11-03 2013-05-10 Quark Pharmaceuticals, Inc. Methods and compositions for neuroprotection
WO2013070821A1 (en) 2011-11-08 2013-05-16 Quark Pharmaceuticals, Inc. Methods and compositions for treating diseases, disorders or injury of the nervous system
WO2013076729A1 (en) 2011-11-23 2013-05-30 Danziger Dan Flower Farm Otomeria plants
WO2013076730A1 (en) 2011-11-27 2013-05-30 Yeda Research And Development Co. Ltd. Methods of regulating angiogenesis and compositions capable of same
WO2013084190A1 (en) 2011-12-08 2013-06-13 Yeda Research And Development Co. Ltd. Mammalian fetal pulmonary cells and therapeutic use of same
EP3034087A1 (en) 2011-12-08 2016-06-22 Yeda Research and Development Co. Ltd. Mammalian fetal pulmonary cells and therapeutic use of same
WO2013093921A1 (en) 2011-12-20 2013-06-27 Collplant Ltd. Collagen coated synthetic polymer fibers
US9726581B2 (en) 2011-12-22 2017-08-08 Realbio Technologies Ltd. Sequential lateral flow capillary device for analyte determination
WO2013093920A2 (en) 2011-12-22 2013-06-27 Yeda Research And Development Co. Ltd. A combination therapy for a stable and long term engraftment
US10598572B2 (en) 2011-12-22 2020-03-24 Realbio Technologies, Ltd. Sequential lateral capillary flow device for analyte determination
WO2013098820A1 (en) 2011-12-28 2013-07-04 Kaiima Bio Agritech Ltd. Cultivated sorghum plant having a partially or fully multiplied genome and uses of same
WO2013098813A1 (en) 2012-01-01 2013-07-04 Qbi Enterprises Ltd. Endo180-targeted particles for selective delivery of therapeutic and diagnostic agents
WO2013114363A2 (en) 2012-01-30 2013-08-08 Yeda Research And Development Co.Ltd. Antimicrobial agents
WO2013114374A1 (en) 2012-02-01 2013-08-08 Protalix Ltd. Dnase i polypeptides, polynucleotides encoding same, methods of producing dnase i and uses thereof in therapy
WO2013114373A1 (en) 2012-02-01 2013-08-08 Protalix Ltd. Inhalable liquid formulations of dnase i
WO2013114371A1 (en) 2012-02-01 2013-08-08 Protalix Ltd. Dry powder formulations of dnase i
US10184131B2 (en) 2012-02-06 2019-01-22 A.B. Seeds Ltd. Isolated polynucleotides expressing or modulating microRNAs or targets of same, transgenic plants comprising same and uses thereof
US10047345B2 (en) 2012-02-13 2018-08-14 Gamida-Cell Ltd. Culturing of mesenchymal stem cells with FGF4 and nicotinamide
WO2013121426A1 (en) 2012-02-13 2013-08-22 Gamida-Cell Ltd. Culturing of mesenchymal stem cells
WO2013121427A1 (en) 2012-02-13 2013-08-22 Gamida-Cell Ltd. Mesenchymal stem cells conditioned medium and methods of generating and using the same
EP3326642A1 (en) 2012-02-14 2018-05-30 OPKO Biologics Ltd. Long-acting coagulation factors and uses thereof
WO2013121416A1 (en) 2012-02-14 2013-08-22 Prolor Biotech Inc. Long-acting coagulation factors and methods of producing same
EP3791890A1 (en) 2012-02-14 2021-03-17 OPKO Biologics Ltd. Long-acting coagulation factors and uses thereof
WO2013121405A1 (en) 2012-02-19 2013-08-22 Protalix Ltd. Oral unit dosage forms and uses of same for the treatment of gaucher disease
EP3401393A1 (en) 2012-02-22 2018-11-14 Exostem Biotec Ltd Micrornas for the generation of astrocytes
EP3401394A1 (en) 2012-02-22 2018-11-14 Exostem Biotec Ltd Generation of neural stem cells
WO2013124816A2 (en) 2012-02-22 2013-08-29 Brainstem Biotec Ltd. Generation of neural stem cells and motor neurons
WO2013124817A2 (en) 2012-02-22 2013-08-29 Brainstem Biotec Ltd. MicroRNAS FOR THE GENERATION OF ASTROCYTES
WO2013128454A1 (en) 2012-03-01 2013-09-06 The State Of Israel, Ministry Of Agriculture & Rural Development, Agricultural Research Organization, (A.R.O.), Volcani Center Male sterile garlic plants, hybrid offspring of same and methods of generating and using same
EP3483184A1 (en) 2012-03-07 2019-05-15 Yeda Research and Development Co. Ltd Compositions for inhibition of quiescinsulfhydryl oxidase (qsox1) and uses of same
WO2013132495A1 (en) 2012-03-07 2013-09-12 Yeda Research And Development Co. Ltd. Compositions for inhibition of quiescin sulfhydryl oxidase (qsox1) and uses of same
WO2013136335A1 (en) 2012-03-15 2013-09-19 Yeda Research And Development Co. Ltd. Isolated pon1 polypeptides, polynucleotides encoding same and uses thereof in treating or preventing organophosphate exposure associated damage
WO2013140389A1 (en) 2012-03-22 2013-09-26 Ramot At Tel-Aviv University Ltd. Plif multimeric peptides and uses thereof
WO2013153553A2 (en) 2012-04-13 2013-10-17 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Compositions for controlling varroa mites in bees
US9925143B2 (en) 2012-04-18 2018-03-27 Ramot At Tel-Aviv University Ltd. Lipidated glycosaminoglycan particles for the delivery of nucleic acids
US9522945B2 (en) 2012-04-19 2016-12-20 Opko Biologics Ltd. Long-acting oxyntomodulin variants and methods of producing same
WO2013160895A1 (en) 2012-04-24 2013-10-31 Biokine Therapeutics Ltd. Peptides and use thereof in the treatment of large cell lung cancer
WO2013168164A1 (en) 2012-05-09 2013-11-14 Yeda Research And Development Co. Ltd. Variants of tace pro-domain as tnf-a inhibitor and their medical use
US8865158B2 (en) 2012-05-22 2014-10-21 Ramot At Tel-Aviv University Ltd. Bacteriophages for reducing toxicity of bacteria
WO2013174003A1 (en) 2012-05-24 2013-11-28 Mountgate Group Limited Compositions and methods related to prevention and treatment of rabies infection
US10240162B2 (en) 2012-05-24 2019-03-26 A.B. Seeds Ltd. Compositions and methods for silencing gene expression
WO2013175480A1 (en) 2012-05-24 2013-11-28 A.B. Seeds Ltd. Compositions and methods for silencing gene expression
EP3508497A1 (en) 2012-05-24 2019-07-10 Mountgate Group Limited Compositions and methods related to prevention and treatment of rabies infection
US10934555B2 (en) 2012-05-24 2021-03-02 Monsanto Technology Llc Compositions and methods for silencing gene expression
US10240161B2 (en) 2012-05-24 2019-03-26 A.B. Seeds Ltd. Compositions and methods for silencing gene expression
US9290564B2 (en) 2012-05-24 2016-03-22 Mountgate Group Limited Compositions and methods related to the prevention and treatment of rabies infection
WO2013183048A1 (en) 2012-06-03 2013-12-12 Ben-Gurion University Of The Negev Research And Development Authority Functionalized titanium binding peptides and implants coated with same
WO2013183052A1 (en) 2012-06-04 2013-12-12 Prolor Biotech Inc. Pegylated oxm variants
US10537646B2 (en) 2012-06-04 2020-01-21 Opko Biologics Ltd. Pegylated OXM variants
US9821070B2 (en) 2012-06-04 2017-11-21 Opko Biologics Ltd. Pegylated OXM variants
WO2014006621A1 (en) 2012-07-03 2014-01-09 Nanospun Technologies Ltd. Methods and devices for adsorption and biodegradation of petroleum
US9567569B2 (en) 2012-07-23 2017-02-14 Gamida Cell Ltd. Methods of culturing and expanding mesenchymal stem cells
US9175266B2 (en) 2012-07-23 2015-11-03 Gamida Cell Ltd. Enhancement of natural killer (NK) cell proliferation and activity
WO2014020599A1 (en) 2012-07-29 2014-02-06 Yeda Research And Development Co. Ltd. Use of the reductive glycine pathway for generating formatotrophic and autotrophic microorganisms
EP3594331A1 (en) 2012-07-29 2020-01-15 Yeda Research and Development Co. Ltd. Use of the reductive glycine pathway for generating formatotrophic and autotrophic microorganisms
WO2014020608A1 (en) 2012-07-31 2014-02-06 Yeda Research And Development Co. Ltd. Methods of diagnosing and treating motor neuron diseases
WO2014024183A1 (en) 2012-08-06 2014-02-13 Brainstorm Cell Therapeutics Ltd. Methods of generating mesenchymal stem cells which secrete neurotrophic factors
WO2014033723A1 (en) 2012-09-03 2014-03-06 A.B. Seeds Ltd. Method of improving abiotic stress tolerance of plants and plants generated thereby
WO2014041544A1 (en) 2012-09-12 2014-03-20 Ramot At Tel-Aviv University Ltd. Immunoparticles and methods of generating and using same
WO2014057490A1 (en) 2012-10-09 2014-04-17 Ramot At Tel-Aviv University Ltd. Methods and kits for predicting prognosis of cancer using soluble mortalin in blood
US9822134B2 (en) 2012-10-22 2017-11-21 Sabag-Rfa Ltd. System for delivering therapeutic agents into living cells and cells nuclei
EP3584259A1 (en) 2012-10-24 2019-12-25 Yeda Research and Development Co., Ltd. Combinations of epidermal growth factor receptor targeting antibodies for treating cancer
WO2014064682A1 (en) 2012-10-24 2014-05-01 Yeda Research And Development Co. Ltd. Combinations of epidermal growth factor receptor targeting antibodies for treating cancer
WO2014068553A1 (en) 2012-10-29 2014-05-08 Yeda Research And Development Co. Ltd. Aptamers, multimeric aptamers and uses thereof
US9808534B2 (en) 2012-11-20 2017-11-07 Opko Biologics Ltd. Method of increasing the hydrodynamic volume of polypeptides by attaching to gonadotrophin carboxy terminal peptides
WO2014083567A2 (en) 2012-11-29 2014-06-05 Yeda Research And Development Co. Ltd. Methods of preventing tumor metastasis, treating and prognosing cancer and identifying agents which are putative metastasis inhibitors
US10683505B2 (en) 2013-01-01 2020-06-16 Monsanto Technology Llc Methods of introducing dsRNA to plant seeds for modulating gene expression
WO2014106838A2 (en) 2013-01-01 2014-07-10 A.B. Seeds Ltd. Methods of introducing dsrna to plant seeds for modulating gene expression
US10041068B2 (en) 2013-01-01 2018-08-07 A. B. Seeds Ltd. Isolated dsRNA molecules and methods of using same for silencing target molecules of interest
WO2014106837A2 (en) 2013-01-01 2014-07-10 A. B. Seeds Ltd. ISOLATED dsRNA MOLECULES AND METHODS OF USING SAME FOR SILENCING TARGET MOLECULES OF INTEREST
WO2014108850A2 (en) 2013-01-09 2014-07-17 Yeda Research And Development Co. Ltd. High throughput transcriptome analysis
WO2014108854A1 (en) 2013-01-09 2014-07-17 Fusimab Ltd. Monospecific anti-hgf and anti-ang2 antibodies and bispecific anti-hgf/anti-ang2 antibodies
US10815477B2 (en) 2013-01-17 2020-10-27 Novellusdx Ltd. Methods and systems for identifying patient specific driver mutations
EP3431985A1 (en) 2013-01-17 2019-01-23 Novellusdx Ltd. Methods and systems for identifying patient specific driver mutations
US10047356B2 (en) 2013-01-17 2018-08-14 Novellusdx Ltd. Methods and systems for identifying patient specific driver mutations
WO2014111936A1 (en) 2013-01-17 2014-07-24 Novellusdx Ltd. Methods and systems for identifying patient specific driver mutations
WO2014118785A1 (en) 2013-02-04 2014-08-07 Ramot At Tel-Aviv University Ltd. Generation of cytotoxic tumor specific cell lines and uses thereof
WO2014136117A1 (en) 2013-03-06 2014-09-12 Protalix Ltd. USE OF PLANT CELLS EXPRESSING A TNFalpha POLYPEPTIDE INHIBITOR IN THERAPY
WO2014136114A1 (en) 2013-03-06 2014-09-12 Protalix Ltd. TNF alpha INHIBITOR POLYPEPTIDES, POLYNUCLEOTIDES ENCODING SAME, CELLS EXPRESSING SAME AND METHODS OF PRODUCING SAME
WO2014136113A1 (en) 2013-03-06 2014-09-12 Protalix Ltd. Chimeric polypeptides, polynucleotides encoding same, cells expressing same and methods of producing same
US10609930B2 (en) 2013-03-13 2020-04-07 Monsanto Technology Llc Methods and compositions for weed control
US10612019B2 (en) 2013-03-13 2020-04-07 Monsanto Technology Llc Methods and compositions for weed control
US10568328B2 (en) 2013-03-15 2020-02-25 Monsanto Technology Llc Methods and compositions for weed control
WO2014147622A1 (en) 2013-03-21 2014-09-25 Collplant Ltd. Compositions comprising collagen and prp for tissue regeneration
WO2014155376A1 (en) 2013-03-24 2014-10-02 Biokine Therapeutics Ltd. Methods of treating myeloid leukemia
WO2014174511A1 (en) 2013-04-21 2014-10-30 Yeda Research And Development Co. Ltd. Agents for downregulation of the activity and/or amount of bcl-xl and/or bcl-w
WO2014174470A1 (en) 2013-04-23 2014-10-30 Yeda Research And Development Co. Ltd. Isolated naive pluripotent stem cells and methods of generating same
WO2014174520A1 (en) 2013-04-25 2014-10-30 Yeda Research And Development Co. Ltd. Use of inhibitory peptides for the treatment of inflammatory diseases
WO2014188423A1 (en) 2013-05-21 2014-11-27 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Treatment of mast cell related pathologies
EP3626310A1 (en) 2013-05-27 2020-03-25 Rakuto Bio Technologies Ltd. Enzymatic system containing cosmetic compositions
WO2014191995A2 (en) 2013-05-27 2014-12-04 Rakuto Bio Technologies Ltd. Enzymatic system-containing cosmetic compositions
WO2014207744A1 (en) 2013-06-24 2014-12-31 Ramot At Tel-Aviv University Ltd. Omentum based scaffold and delivery system
US9850496B2 (en) 2013-07-19 2017-12-26 Monsanto Technology Llc Compositions and methods for controlling Leptinotarsa
US11377667B2 (en) 2013-07-19 2022-07-05 Monsanto Technology Llc Compositions and methods for controlling Leptinotarsa
US9856495B2 (en) 2013-07-19 2018-01-02 Monsanto Technology Llc Compositions and methods for controlling Leptinotarsa
US10597676B2 (en) 2013-07-19 2020-03-24 Monsanto Technology Llc Compositions and methods for controlling Leptinotarsa
US9777288B2 (en) 2013-07-19 2017-10-03 Monsanto Technology Llc Compositions and methods for controlling leptinotarsa
WO2015015489A1 (en) 2013-07-30 2015-02-05 Biolinerx Ltd. Antibody for treating diabetes and autoimmune diseases
US9938316B2 (en) 2013-08-29 2018-04-10 Yeda Research And Development Co. Ltd. Selective inhibitors of α2 isoform of Na,K-ATPase and use thereof for reduction of intra-ocular pressure and as cardiotonic agents
WO2015033337A1 (en) 2013-09-03 2015-03-12 Technion Research & Development Foundation Limited. A flap for de-novo tissue regeneration
WO2015033343A1 (en) 2013-09-03 2015-03-12 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Compositions and methods for expressing recombinant polypeptides
WO2015033344A1 (en) 2013-09-05 2015-03-12 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Methods and kits for inhibiting pathogenicity of group a streptococcus (gas) or group g streptococcus (ggs)
WO2015037009A1 (en) 2013-09-16 2015-03-19 Plexicure Ltd. Isolated proteins capable of binding plexin-a4 and methods of producing and using same
WO2015040609A1 (en) 2013-09-17 2015-03-26 Yeda Research And Development Co. Ltd. Erk-derived peptides and uses thereof
WO2015049677A1 (en) 2013-10-01 2015-04-09 Kadimastem Ltd. Directed differentiation of astrocytes from human pluripotent stem cells for use in drug screening and the treatment of amyotrophic lateral sclerosis (als)
US11197915B2 (en) 2013-10-21 2021-12-14 Opko Biologics Ltd. Long-acting polypeptides and methods of producing and administering same
EP3763733A1 (en) 2013-10-21 2021-01-13 OPKO Biologics Ltd. Long-acting polypeptides and methods of producing and administering same
WO2015059695A1 (en) 2013-10-21 2015-04-30 Opko Biologics Ltd. Long-acting polypeptides and methods of producing and administering same
US10767156B2 (en) 2013-10-24 2020-09-08 Yeda Research And Development Co., Ltd. Polynucleotides encoding BREX system polypeptides and methods of using same
WO2015059690A1 (en) 2013-10-24 2015-04-30 Yeda Research And Development Co. Ltd. Polynucleotides encoding brex system polypeptides and methods of using s ame
WO2015063768A1 (en) 2013-10-31 2015-05-07 Biokine Therapeutics Ltd. Methods of treating acute myeloid leukemia with a flt3 mutation
US10100306B2 (en) 2013-11-04 2018-10-16 Monsanto Technology Llc Compositions and methods for controlling arthropod parasite and pest infestations
US10927374B2 (en) 2013-11-04 2021-02-23 Monsanto Technology Llc Compositions and methods for controlling arthropod parasite and pest infestations
US9540642B2 (en) 2013-11-04 2017-01-10 The United States Of America, As Represented By The Secretary Of Agriculture Compositions and methods for controlling arthropod parasite and pest infestations
WO2015079411A1 (en) 2013-11-28 2015-06-04 Tel Hashomer Medical Research Infrastructure And Services Ltd. Rna polymerase i inhibitors and uses thereof
WO2015079413A2 (en) 2013-11-28 2015-06-04 Yeda Research And Development Co. Ltd. Synaptojanin-2 inhibitors and uses thereof
WO2015087327A1 (en) 2013-12-10 2015-06-18 Yeda Research And Development Co. Ltd. Use of enzymes which catalyze pyruvate synthesis from formate and acetyl-coa and bacteria expressing same
US10557138B2 (en) 2013-12-10 2020-02-11 Beeologics, Inc. Compositions and methods for virus control in Varroa mite and bees
US10334848B2 (en) 2014-01-15 2019-07-02 Monsanto Technology Llc Methods and compositions for weed control using EPSPS polynucleotides
WO2015114633A1 (en) 2014-01-30 2015-08-06 Yissum Research And Development Company Of The Hebrew University Of Jerusalem Ltd. Actin binding peptides and compositions comprising same for inhibiting angiogenes is and treating medical conditions associated with same
WO2015114638A2 (en) 2014-02-03 2015-08-06 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Method of eliminating stem cells
WO2015118537A2 (en) 2014-02-05 2015-08-13 Yeda Research And Development Co. Ltd. Micro-rnas and compositions comprising same for the treatment and diagnosis of serotonin-, adrenalin-, noradrenalin-, glutamate-, and corticotropin-releasing hormone- associated medical conditions
WO2015118538A1 (en) 2014-02-06 2015-08-13 Yeda Research And Development Co. Ltd. Anti cd84 antibodies, compositions comprising same and uses thereof
WO2015118547A1 (en) 2014-02-10 2015-08-13 Protalix Ltd. Method of maintaining disease stability in a subject having gaucher's disease
WO2015121859A1 (en) 2014-02-11 2015-08-20 Brainstorm Cell Therapeutics Ltd. Method of qualifying cells
WO2015132784A1 (en) 2014-03-03 2015-09-11 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Method and device for detection of pseudomonas aeruginosa
US10183066B2 (en) 2014-03-28 2019-01-22 Fraunhofer-Gesellschaft Zur Foerderung Der Angewandten Forschung E.V Multi-component-multistage malaria vaccines
EP2923709A1 (en) 2014-03-28 2015-09-30 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Multi-component-multistage malaria vaccine
WO2015144874A1 (en) 2014-03-28 2015-10-01 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Multi-component-multistage malaria vaccines
US11091770B2 (en) 2014-04-01 2021-08-17 Monsanto Technology Llc Compositions and methods for controlling insect pests
US11433163B2 (en) 2014-04-10 2022-09-06 Bonus Therapeutics Ltd. Bone repair compositions
EP4306659A2 (en) 2014-04-14 2024-01-17 Yissum Research and Development Company of the Hebrew University of Jerusalem Ltd. A method and kit for determining the tissue or cell origin of dna
EP3643795A1 (en) 2014-04-14 2020-04-29 Yissum Research and Development Company of the Hebrew University of Jerusalem Ltd. A method for determining the death of cells or tissue by dna methylation analysis
WO2015159292A2 (en) 2014-04-14 2015-10-22 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. A method and kit for determining the tissue or cell origin of dna
WO2015159293A2 (en) 2014-04-14 2015-10-22 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. A method and kit for determining the tissue or cell origin of dna
EP4026917A1 (en) 2014-04-14 2022-07-13 Yissum Research and Development Company of the Hebrew University of Jerusalem Ltd. A method and kit for determining the death of cells or tissue or the tissue or cell origin of dna by dna methylation analysis
WO2015159295A1 (en) 2014-04-17 2015-10-22 Yeda Research And Development Co. Ltd. Methods and kits for analyzing dna binding moieties attached to dna
US11427647B2 (en) 2014-04-27 2022-08-30 Famewave Ltd. Polynucleotides encoding humanized antibodies against CEACAM1
US10550196B2 (en) 2014-04-27 2020-02-04 Famewave Ltd. Humanized antibodies against CEACAM1
US11866509B2 (en) 2014-04-27 2024-01-09 Famewave Ltd. Humanized antibodies against CEACAM1
WO2015166492A2 (en) 2014-04-28 2015-11-05 Yeda Research And Development Co. Ltd. Microbiome response to agents
WO2015170320A2 (en) 2014-05-04 2015-11-12 Forrest Innovations Ltd. Compositions and methods of using same for controlling pathogenically infected mosquitoes
WO2015170322A2 (en) 2014-05-04 2015-11-12 Forrest Innovations Ltd. Compositions and methods of using same for increasing resistance of infected mosquitoes
WO2015170323A2 (en) 2014-05-04 2015-11-12 Forrest Innovations Ltd. Compositions and methods of using same for reducing resistance to mosquito larvicides
WO2015170324A2 (en) 2014-05-04 2015-11-12 Forrest Innovations Ltd. Compositions for mosquito control and uses of same
WO2015170325A2 (en) 2014-05-04 2015-11-12 Forrest Innovations Ltd. Compositions and methods for reducing pathogen-induced citrus greening
WO2015177800A2 (en) 2014-05-22 2015-11-26 Yeda Research And Development Co. Ltd. Recombinant microorganisms capable of carbon fixation
WO2015186129A1 (en) 2014-06-02 2015-12-10 Technion Research & Development Foundation Limited. Compositions and methods of selectively inhibiting irp1 and treating inflammation
WO2015186128A1 (en) 2014-06-02 2015-12-10 Kadimastem Ltd. Methods of inducing myelination and maturation of oligodendrocytes
US10988764B2 (en) 2014-06-23 2021-04-27 Monsanto Technology Llc Compositions and methods for regulating gene expression via RNA interference
WO2015198320A1 (en) 2014-06-24 2015-12-30 Insight Biopharmaceuticals Ltd. Methods of purifying antibodies
WO2015198334A2 (en) 2014-06-25 2015-12-30 Tel Hashomer Medical Research Infrastructure And Services Ltd. Identification of cancer stem cells and use of same for diagnosis and treatment
US11807857B2 (en) 2014-06-25 2023-11-07 Monsanto Technology Llc Methods and compositions for delivering nucleic acids to plant cells and regulating gene expression
US10583084B2 (en) 2014-06-26 2020-03-10 Ramot At Tel-Aviv University Ltd. Liposomal formulations for delivery of nucleic acids
WO2016005985A2 (en) 2014-07-09 2016-01-14 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Method for reprogramming cells
US11560417B2 (en) 2014-07-15 2023-01-24 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Isolated polypeptides of CD44 and uses thereof
WO2016009436A1 (en) 2014-07-15 2016-01-21 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Isolated polypeptides of cd44 and uses thereof
US10611819B2 (en) 2014-07-15 2020-04-07 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Isolated polypeptides of CD44 and uses thereof
US10550439B2 (en) 2014-07-21 2020-02-04 Novellusdx Ltd. Methods for determining drug response of patient specific mutations
US11015229B2 (en) 2014-07-21 2021-05-25 Novellusdx Ltd. Methods and systems for determining oncogenic index of patient specific mutations
US10378012B2 (en) 2014-07-29 2019-08-13 Monsanto Technology Llc Compositions and methods for controlling insect pests
US11124792B2 (en) 2014-07-29 2021-09-21 Monsanto Technology Llc Compositions and methods for controlling insect pests
WO2016016894A1 (en) 2014-07-30 2016-02-04 Yeda Research And Development Co. Ltd. Media for culturing pluripotent stem cells
EP3699930A2 (en) 2014-08-14 2020-08-26 MeMed Diagnostics Ltd. Computational analysis of biological data using manifold and a hyperplane
WO2016024278A1 (en) 2014-08-14 2016-02-18 Memed Diagnostics Ltd. Computational analysis of biological data using manifold and a hyperplane
WO2016030899A1 (en) 2014-08-28 2016-03-03 Yeda Research And Development Co. Ltd. Methods of treating amyotrophic lateral scleroses
WO2016038609A1 (en) 2014-09-08 2016-03-17 Yeda Research And Development Co. Ltd. Anti-her3 antibodies and uses of same
US10213501B2 (en) 2014-09-08 2019-02-26 Fraunhofer-Gesellschaft Zur Foerderung Der Angewandten Forschung E.V. Three-component-multistage malaria vaccine
EP2992895A1 (en) 2014-09-08 2016-03-09 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Three-component-multistage malaria vaccine
WO2016038610A1 (en) 2014-09-08 2016-03-17 Yeda Research And Development Co. Ltd. Compositions and methods for treating cancer resistant to a tyrosine kinase inhibitor (tki)
WO2016038616A1 (en) 2014-09-14 2016-03-17 Yeda Research And Development Co. Ltd. Nmda receptor antagonists for treating gaucher disease
WO2016042561A2 (en) 2014-09-21 2016-03-24 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Downregulating mir-132 for the treatment of lipid related disorders
EP3739062A1 (en) 2014-10-20 2020-11-18 Gen-Probe Incorporated Red blood cell lysis solution
DE102015220401A1 (en) 2014-10-20 2016-05-19 Gen-Probe Incorporated Erythrocyte lysis solution
WO2016064887A1 (en) 2014-10-20 2016-04-28 Gen-Probe Incorporated Red blood cell lysis solution
US11624052B2 (en) 2014-11-13 2023-04-11 Enzootic Holdings Ltd. Functional sex-reversal of decapod crustacean females
WO2016075697A1 (en) 2014-11-13 2016-05-19 Enzootic Holdings Ltd. Functional sex-reversal of decapod crustacean females
WO2016079736A2 (en) 2014-11-17 2016-05-26 Yeda Research And Development Co. Ltd. Methods of treating diseases related to mitochondrial function
WO2016079731A2 (en) 2014-11-17 2016-05-26 Yeda Research And Development Co. Ltd. Method of analyzing microbiome
WO2016079739A2 (en) 2014-11-20 2016-05-26 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Compositions and methods for producing polypeptides with a modified glycosylation pattern in plant cells
US11697819B2 (en) 2014-11-20 2023-07-11 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd Compositions and methods for producing polypeptides with a modified glycosylation pattern in plant cells
WO2016084088A1 (en) 2014-11-26 2016-06-02 Ramot At Tel-Aviv University Ltd. Targeted elimination of bacterial genes
WO2016084084A1 (en) 2014-11-27 2016-06-02 Danziger Innovations Ltd. Nucleic acid constructs for genome editing
WO2016092555A2 (en) 2014-12-11 2016-06-16 Yeda Research And Development Co. Ltd. Isolated phosphotriesterase polypeptides, polynucleotides encoding same and uses thereof in treating or preventing organophosphate exposure associated damage
WO2016103269A1 (en) 2014-12-23 2016-06-30 Ramot At Tel-Aviv University Ltd. Populations of neural progenitor cells and methods of producing and using same
US11891622B2 (en) 2014-12-30 2024-02-06 Cell Cure Neurosciences Ltd. RPE cell populations and methods of generating same
WO2016108219A1 (en) 2014-12-30 2016-07-07 Cell Cure Neurosciences Ltd. Methods of treating retinal diseases
WO2016108240A1 (en) 2014-12-30 2016-07-07 Cell Cure Neurosciences Ltd. Assessing retinal pigment epithelial cell populations
EP3674397A1 (en) 2014-12-30 2020-07-01 Cell Cure Neurosciences Ltd. Rpe cell populations and methods of generating same
EP3916085A1 (en) 2014-12-30 2021-12-01 Cell Cure Neurosciences Ltd. Assessing retinal pigment epithelial cell populations
WO2016108239A1 (en) 2014-12-30 2016-07-07 Cell Cure Neurosciences Ltd. Rpe cell populations and methods of generating same
WO2016108244A1 (en) 2015-01-04 2016-07-07 Protalix Ltd. Modified dnase and uses thereof
WO2016116935A1 (en) 2015-01-21 2016-07-28 Yeda Research And Development Co. Ltd. Use of rasa2 as a prognostic and therapeutic marker for melanoma
US10968449B2 (en) 2015-01-22 2021-04-06 Monsanto Technology Llc Compositions and methods for controlling Leptinotarsa
WO2016135732A1 (en) 2015-02-26 2016-09-01 Yeda Research And Development Co. Ltd. Method of promoting hair growth
WO2016142948A1 (en) 2015-03-11 2016-09-15 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Decoy oligonucleotides for the treatment of diseases
WO2016147194A1 (en) 2015-03-19 2016-09-22 Yeda Research And Development Co. Ltd. Anti amphiregulin antibodies, compositions comprising same and uses thereof
WO2016160618A2 (en) 2015-03-27 2016-10-06 University Of Southern California Car t-cell therapy directed to lhr for the treatment of solid tumors
EP4218771A1 (en) 2015-03-27 2023-08-02 Yeda Research and Development Co. Ltd Methods of treating motor neuron diseases
WO2016157190A1 (en) 2015-03-31 2016-10-06 Yeda Research And Development Co. Ltd. Glutamate oxaloacetate transaminase 1 (got1), preparations and methods of generating same and uses thereof
WO2016157192A1 (en) 2015-04-01 2016-10-06 The State Of Israel, Ministry Of Agriculture & Rural Development, Agricultural Research Organization (Aro) (Volcani Center) Erodium crassifolium l'her plant extracts and uses thereof
WO2016162870A1 (en) 2015-04-07 2016-10-13 Ilana Nathan Compositions for treating and/or preventing cell or tissue necrosis specifically targeting cathepsin c and/or cela1 and/or cela3a and/or structurally related enzymes thereto
EP4005569A2 (en) 2015-04-07 2022-06-01 ELA Pharma Ltd Compositions for treating and/or preventing cell or tissue necrosis specifically targeting cathepsin c and/or cela1 and/or cela3a and/or structurally related enzymes thereto
US10577412B2 (en) 2015-04-12 2020-03-03 Fraunhofer-Gesellschaft Zur Foerderung Der Angewandten Forschung E.V. Anti-plasmodium parasite antibodies
WO2016174674A1 (en) 2015-04-27 2016-11-03 The Medical Research, Infrastructure and Health Services Fund of the Tel Aviv Medical Center Egr1 targeting molecules for the treatment of inflammatory and hyperproliferative conditions
WO2016174673A1 (en) 2015-04-29 2016-11-03 The State Of Israel, Ministry Of Agriculture & Rural Development, Agricultural Research Organization (Aro) (Volcani Center) Anti-phytopathogenic compositions
US10674732B2 (en) 2015-04-29 2020-06-09 The State Of Israel, Ministry Of Agriculture & Rural Development Agricultural Research Organization Anti-phytopathogenic compositions
WO2016174652A1 (en) 2015-04-30 2016-11-03 Technion Research & Development Foundation Limited Chimeric antigen receptors and methods of their use
WO2016178207A1 (en) 2015-05-04 2016-11-10 Ramot At Tel-Aviv University Ltd. Methods and kits for fragmenting dna
WO2016181393A1 (en) 2015-05-11 2016-11-17 Yeda Research And Development Co. Ltd. Citrin inhibitors for the treatment of cancer
WO2016185471A1 (en) 2015-05-17 2016-11-24 The Medical Research, Infrastructure and Health Services Fund of the Tel Aviv Medical Center Compositions and methods for treating cancer
WO2016185457A1 (en) 2015-05-19 2016-11-24 Yeda Research And Development Co. Ltd. Methods of promoting lymphangiogenesis
WO2016185481A2 (en) 2015-05-20 2016-11-24 Yeda Research And Development Co. Ltd. Method of targeting senescent cells
WO2016185469A1 (en) 2015-05-21 2016-11-24 Yeda Research And Development Co. Ltd. Bacterial populations for promoting health
WO2016193969A2 (en) 2015-05-29 2016-12-08 Opko Biologics Ltd. Pegylated oxyntomodulin variants
US10883103B2 (en) 2015-06-02 2021-01-05 Monsanto Technology Llc Compositions and methods for delivery of a polynucleotide into a plant
US10655136B2 (en) 2015-06-03 2020-05-19 Monsanto Technology Llc Methods and compositions for introducing nucleic acids into plants
WO2016197064A1 (en) 2015-06-04 2016-12-08 Epstein Alan L Lym-1 and lym-2 targeted car cell immunotherapy
WO2016199141A2 (en) 2015-06-08 2016-12-15 Adicet Bio Inc. Affinity entities comprising a tcr-like antibody binding domain with high affinity and fine specificity and uses of same
WO2016199140A1 (en) 2015-06-08 2016-12-15 Adicet Bio Inc. T cell receptor like antibodies having fine specificity
EP4039270A1 (en) 2015-06-08 2022-08-10 Adicet Bio Inc. Affinity entities comprising a tcr-like antibody binding domain with high affinity and fine specificity and uses of same
EP4026563A1 (en) 2015-06-18 2022-07-13 Yeda Research and Development Co. Ltd Conditioning protocols and use of same for tissue regeneration
WO2016203476A1 (en) 2015-06-18 2016-12-22 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Methods and compositions for diagnosing and treating urothelial cancer
WO2016203477A1 (en) 2015-06-18 2016-12-22 Yeda Research And Development Co. Ltd. Conditioning protocols and use of same for tissue regeneration
US10960058B2 (en) 2015-06-19 2021-03-30 Opko Biologics Ltd. Long-acting coagulation factors and methods of producing same
WO2016203482A2 (en) 2015-06-19 2016-12-22 Opko Biologics Ltd. Long-acting coagulation factors and methods of producing same
EP3988113A1 (en) 2015-06-19 2022-04-27 OPKO Biologics Ltd. Long-acting coagulation factors and methods of producing same
WO2017009853A1 (en) 2015-07-16 2017-01-19 Yeda Research And Development Co. Ltd. Genetically modified anti-third party central memory t cells and use of same in immunotherapy
EP3744340A2 (en) 2015-07-16 2020-12-02 Biokine Therapeutics Ltd. Compositions and methods for treating cancer
WO2017009842A2 (en) 2015-07-16 2017-01-19 Biokine Therapeutics Ltd. Compositions and methods for treating cancer
EP3943098A2 (en) 2015-07-16 2022-01-26 Biokine Therapeutics Ltd. Compositions and methods for treating cancer
WO2017009852A1 (en) 2015-07-16 2017-01-19 Yeda Research And Development Co. Ltd. Use of anti third party central memory t cells
US11077128B2 (en) 2015-07-19 2021-08-03 Yeda Research And Development Co. Ltd. Selective inhibitors of Alpha2-containing isoforms of Na,K-ATPase and use thereof for reduction of intraocular pressure
US10668094B2 (en) 2015-07-19 2020-06-02 Yeda Research And Development Co. Ltd. Selective inhibitors of Alpha2-containing isoforms of Na,K-ATPase and use thereof for reduction of intraocular pressure
WO2017013661A1 (en) 2015-07-22 2017-01-26 Phytopharma International Ltd. Bee-ingestible compositions, methods of using same for producing honey and honey produced thereby
EP3862425A1 (en) 2015-07-29 2021-08-11 Hadasit Medical Research Services and Development Ltd. Large scale production of retinal pigment epithelial cells
US11230696B2 (en) 2015-07-29 2022-01-25 Hadasit Medical Research Services And Development Ltd. Large scale production of retinal pigment epithelial cells
WO2017017686A1 (en) 2015-07-29 2017-02-02 Hadasit Medical Research Services And Development Ltd. Large scale production of retinal pigment epithelial cells
WO2017021963A1 (en) 2015-08-03 2017-02-09 Biokine Therapeutics Ltd. Cxcr4 binding agents for treatment of diseases
WO2017021961A1 (en) 2015-08-04 2017-02-09 Yeda Research And Development Co. Ltd. Methods of screening for riboswitches and attenuators
US11090337B2 (en) 2015-08-05 2021-08-17 Cell Cure Neurosciences Ltd Preparation of photoreceptors for the treatment of retinal diseases
WO2017021973A1 (en) 2015-08-05 2017-02-09 Cell Cure Neurosciences Ltd. Preparation of retinal pigment epithelium cells
US11066642B2 (en) 2015-08-05 2021-07-20 Cell Cure Neurosciences Ltd Preparation of retinal pigment epithelium cells
EP4155391A1 (en) 2015-08-05 2023-03-29 Cell Cure Neurosciences Ltd. Preparation of retinal pigment epithelium cells
WO2017021972A1 (en) 2015-08-05 2017-02-09 Cell Cure Neurosciences Ltd. Preparation of photoreceptors for the treatment of retinal diseases
WO2017025963A1 (en) 2015-08-10 2017-02-16 The Medical Research, Infrastructure and Health Services Fund of the Tel Aviv Medical Center Methods and pharmaceutical compositions for improving wound healing using cd24
WO2017025967A1 (en) 2015-08-13 2017-02-16 Forrest Innovations Ltd. Formulations and compositions for delivery of nucleic acids to plant cells
WO2017033188A1 (en) 2015-08-24 2017-03-02 Yeda Research And Development Co. Ltd. Algal oil and biofuel and methods of producing same
US10765706B2 (en) 2015-09-03 2020-09-08 University Of South Florida Method of stem cell delivery into the brain during chronic disease using blood brain barrier permeabilizers
WO2017042814A1 (en) 2015-09-10 2017-03-16 Yeda Research And Development Co. Ltd. Use of perforin positive immature dendritic cells in disease treatment
WO2017072757A1 (en) 2015-10-25 2017-05-04 Yeda Research And Development Co. Ltd. Antibodies targeting quiescin sulfhydryl oxidase (qsox1) and uses of same
WO2017072763A1 (en) 2015-10-26 2017-05-04 Cell Cure Neurosciences Ltd. Preparation of retinal pigment epithelium cells
WO2017072773A1 (en) 2015-10-27 2017-05-04 Ilana Nathan Compositions comprising cannabidiol and second therapeutic agents for the treatment of cancer
WO2017072772A1 (en) 2015-10-29 2017-05-04 Yeda Research And Development Co. Ltd. A method of inducing cardiomyocytes proliferation and treating heart diseases
WO2017077539A1 (en) 2015-11-03 2017-05-11 Ariel-University Research And Development Company Ltd. Compositions for regeneration and repair of neural tissue
WO2017081689A1 (en) 2015-11-11 2017-05-18 Ramot At Tel-Aviv University Ltd. Methods of detecting 5-hydroxymethylcytosine and diagnosing of cancer
EP4231015A1 (en) 2015-11-30 2023-08-23 Kadimastem Ltd. Methods for differentiating and purifying pancreatic endocrine cells
WO2017094001A1 (en) 2015-11-30 2017-06-08 Kadimastem Ltd Methods for differentiating and purifying pancreatic endocrine cells
EP3176183A1 (en) 2015-12-02 2017-06-07 Yeda Research and Development Co. Ltd Compositions and methods for treating cancer not resistant to a tyrosine kinase inhibitor (tki)
EP4059507A1 (en) 2015-12-16 2022-09-21 Ramot at Tel-Aviv University Ltd. Particles comprising decellularized omentum
US10561706B2 (en) 2015-12-28 2020-02-18 B. G. Negev Technologies And Applications Isolated polypeptide and compositions comprising same
WO2017118985A1 (en) 2016-01-06 2017-07-13 Yeda Research And Development Co. Ltd. Compositions and methods for treating malignant, autoimmune and inflammatory diseases
WO2017122203A1 (en) 2016-01-11 2017-07-20 Technion Research & Development Foundation Limited Methods of determining prognosis of sepsis and treating same
WO2017125931A1 (en) 2016-01-21 2017-07-27 The State Of Israel, Ministry Of Agriculture & Rural Development, Agricultural Research Organization (Aro) (Volcani Center) Parthenocarpic plants and methods of producing same
US10964443B2 (en) 2016-01-28 2021-03-30 Sp Nano Ltd. Conductive yarn
US10954313B2 (en) 2016-01-28 2021-03-23 Sp Nano Ltd. Composition comprising SP1 and carbon based nanoparticles and uses thereof
WO2017130205A1 (en) 2016-01-31 2017-08-03 Hadasit Medical Research Services And Development Ltd. Autosomal-identical pluripotent stem cell populations having non-identical sex chromosomal composition and uses thereof
WO2017134671A1 (en) 2016-02-04 2017-08-10 Yeda Research And Development Co. Ltd. Peptides and use of same in the treatment of diseases, disorders or conditions associated with a mutant p53
US11230578B2 (en) 2016-02-04 2022-01-25 Yeda Research And Development Co. Ltd. Peptides and use of same in the treatment of diseases, disorders or conditions associated with a mutant P53
EP3708675A1 (en) 2016-02-14 2020-09-16 Yeda Research and Development Co. Ltd. Microbiome-based diagnosis, prediction and treatment of relapsing obesity
WO2017138007A1 (en) 2016-02-14 2017-08-17 Yeda Research And Development Co. Ltd. At The Weizmann Institute Of Science Microbiome-based diagnosis, prediction and treatment of relapsing obesity
WO2017138008A2 (en) 2016-02-14 2017-08-17 Yeda Research And Development Co. Ltd. Methods of modulating protein exocytosis and uses of same in therapy
WO2017141253A1 (en) 2016-02-16 2017-08-24 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Non-protein phenylalanine analogues for inhibiting cyanobacteria and plant growth
WO2017145162A1 (en) 2016-02-23 2017-08-31 Chaya Brodie Generation of cancer stem cells and use thereof
US10906987B2 (en) 2016-03-01 2021-02-02 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Antibodies specific to human poliovirus receptor (PVR)
EP3907292A1 (en) 2016-03-03 2021-11-10 Memed Diagnostics Ltd. Analyzing rna for diagnosing infection type
WO2017149547A1 (en) 2016-03-03 2017-09-08 Memed Diagnostics Ltd. Analyzing rna for diagnosing infection type
WO2017153982A1 (en) 2016-03-06 2017-09-14 Yeda Research And Development Co. Ltd. Method for modulating myelination
WO2017158610A1 (en) 2016-03-17 2017-09-21 Yeda Research And Development Co. Ltd. Methods of isolating barrel-like proteases and identifying peptides processed thereby
US10421785B2 (en) 2016-04-11 2019-09-24 Bar-Ilan University Delta receptor agonist peptides and use thereof
WO2017189746A1 (en) 2016-04-27 2017-11-02 Gen-Probe Incorporated Blood cell lysis reagent
DE202017007129U1 (en) 2016-04-27 2019-08-29 Gen-Probe Incorporated Lysis reagent for blood cells
DE202017007130U1 (en) 2016-04-27 2019-08-29 Gen-Probe Inc. Lysis reagent for blood cells
EP3736332A1 (en) 2016-04-27 2020-11-11 Gen-Probe Incorporated Blood cell lysis reagent
WO2017203520A1 (en) 2016-05-22 2017-11-30 Yeda Research And Development Co. Ltd. Methods of using pulmonary cells for transplantation and induction of tolerance
WO2017203532A1 (en) 2016-05-25 2017-11-30 Yeda Research And Development Co. Ltd. At The Weizmann Institute Of Science Agents for use treating drug resistant tumors and triple negative breast cancer
WO2017208247A1 (en) 2016-06-02 2017-12-07 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Assay for the removal of methyl-cytosine residues from dna
WO2017212476A1 (en) 2016-06-05 2017-12-14 Tel Hashomer Medical Research Infrastructure And Services Ltd. Novel molecules for the treatment of inflammation
WO2017212494A1 (en) 2016-06-09 2017-12-14 Opko Biologics Ltd. Long-acting oxyntomodulin formulation and methods of producing and administering same
WO2017221225A1 (en) 2016-06-19 2017-12-28 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Screening for chemotherapy resistance in human haploid cells
US11859232B2 (en) 2016-06-19 2024-01-02 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Screening for chemotherapy resistance in human haploid cells
WO2018002924A1 (en) 2016-06-27 2018-01-04 Yeda Research And Development Co. Ltd. Veto cells generated from memory t cells
WO2018011796A1 (en) 2016-07-10 2018-01-18 Memed Diagnostics Ltd. Early diagnosis of infections
WO2018011795A1 (en) 2016-07-10 2018-01-18 Memed Diagnostics Ltd. Protein signatures for distinguishing between bacterial and viral infections
EP4184167A1 (en) 2016-07-10 2023-05-24 MeMed Diagnostics Ltd. Early diagnosis of infections
EP4141448A1 (en) 2016-07-10 2023-03-01 MeMed Diagnostics Ltd. Protein signatures for distinguishing between bacterial and viral infections
WO2018011804A1 (en) 2016-07-11 2018-01-18 Bonus Therapeutics Ltd. Cell compositions for tissue regeneration
WO2018011805A2 (en) 2016-07-11 2018-01-18 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Systems and methods for growing cells in vitro
WO2018011799A1 (en) 2016-07-11 2018-01-18 Opko Biologics Ltd. Long-acting coagulation factor vii and methods of producing same
EP4303228A2 (en) 2016-07-11 2024-01-10 OPKO Biologics Ltd. Long-acting coagulation factor vii and methods of producing same
WO2018011806A1 (en) 2016-07-11 2018-01-18 Yeda Research And Development Co. Ltd. Combination therapy to increase endogenous nitric oxide (no) synthesis
WO2018020489A1 (en) 2016-07-24 2018-02-01 Yeda Research And Development Co. Ltd. Methods and kits for analyzing dna binding moieties attached to dna
WO2018029682A1 (en) 2016-08-08 2018-02-15 Ramot At Tel-Aviv University Ltd. Bacterial systems for analyzing ubiquitylated polypeptides
EP4033248A1 (en) 2016-08-10 2022-07-27 MeMed Diagnostics Ltd. System and method for analysis of biological data
WO2018029690A1 (en) 2016-08-10 2018-02-15 Memed Diagnostics Ltd. System and method for analysis of biological data
US11129852B2 (en) 2016-08-14 2021-09-28 Ramot At Tel Aviv University Ltd. Mesenchymal cell-derived exosomes to treat neurological disorders
WO2018033911A1 (en) 2016-08-14 2018-02-22 Ramot At Tel-Aviv University Ltd. Mesenchymal cell-derived exosomes to treat neurological disorders
WO2018033929A1 (en) 2016-08-18 2018-02-22 Yeda Research And Development Co. Ltd. Diagnostic and therapeutic uses of exosomes
WO2018037416A1 (en) 2016-08-25 2018-03-01 Yeda Research And Development Co. Ltd. Methods and compositions for treating autoimmune diseases
US10716864B2 (en) 2016-09-07 2020-07-21 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Anti-NKP46 antibodies, toxin conjugates, and therapeutic use of same
WO2018047154A1 (en) 2016-09-07 2018-03-15 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Anti-nkp46 antibodies and therapeutic use of same
WO2018051347A1 (en) 2016-09-14 2018-03-22 Yeda Research And Development Co. Ltd. Crisp-seq, an integrated method for massively parallel single cell rna-seq and crispr pooled screens
WO2018069885A1 (en) 2016-10-13 2018-04-19 Technion Research & Development Foundation Limited Use of caspase-3 inhibitors and caspase-3 activators in the manufacture of medicament for treating cancer and wound healing
WO2018073823A2 (en) 2016-10-18 2018-04-26 Yeda Research And Development Co. Ltd. Treatment of a circadian rhythm disorder
WO2018087759A1 (en) 2016-11-10 2018-05-17 Yeda Research And Development Co. Ltd. Phosphotriesterases for treating or preventing organophosphate exposure associated damage
WO2018096547A1 (en) 2016-11-28 2018-05-31 Yeda Research And Development Co. Ltd. Isolated polynucleotides and polypeptides and methods of using same for expressing an expression product of interest
WO2018100574A1 (en) 2016-11-30 2018-06-07 Yeda Research And Development Co. Ltd. Methods of treating liver toxicity and disorders
WO2018100511A1 (en) 2016-12-01 2018-06-07 Ramot At Tel-Aviv University Ltd. Combined treatment for nerve injuries
WO2018134824A1 (en) 2017-01-18 2018-07-26 Yeda Research And Development Co. Ltd. Genetically modified veto cells and use of same in immunotherapy
WO2018142416A1 (en) 2017-02-06 2018-08-09 Yeda Research And Development Co. Ltd. Isolated cells genetically modified to express a disarm system having an anti-phage activity and methods of producing same
WO2018158775A1 (en) 2017-03-02 2018-09-07 Yeda Research And Development Co. Ltd. Methods of culturing t cells and uses of same
WO2018167780A1 (en) 2017-03-12 2018-09-20 Yeda Research And Development Co. Ltd. Methods of prognosing and treating cancer
WO2018167778A1 (en) 2017-03-12 2018-09-20 Yeda Research And Development Co. Ltd. Methods of diagnosing and prognosing cancer
WO2018170494A1 (en) 2017-03-16 2018-09-20 Bio Time, Inc. Methods for measuring therapeutic effects of retinal disease therapies
WO2018185760A1 (en) 2017-04-05 2018-10-11 Yeda Research And Development Co. Ltd. Ex-vivo culture system and methods of using same
EP4317971A2 (en) 2017-04-05 2024-02-07 Yeda Research and Development Co. Ltd Ex-vivo culture system and methods of using same
EP3821888A1 (en) 2017-05-07 2021-05-19 Yeda Research and Development Co. Ltd Lxr agonists for treating psychiatric stress disorders
WO2018207178A1 (en) 2017-05-07 2018-11-15 Yeda Research And Development Co. Ltd. Methods of treating psychiatric stress disorders
WO2018207184A2 (en) 2017-05-10 2018-11-15 Ariel Scientific Innovations Ltd. Methods of purifying antibodies
WO2018216006A1 (en) 2017-05-21 2018-11-29 The Medical Research, Infrastructure and Health Services Fund of the Tel Aviv Medical Center Combination of markers for diagnosing cancer
WO2018216011A1 (en) 2017-05-23 2018-11-29 Technion Research & Development Foundation Limited Agents which inhibit gads dimerization and methods of use thereof
WO2018220581A1 (en) 2017-05-31 2018-12-06 Tropic Biosciences UK Limited Compositions and methods for increasing shelf-life of banana
WO2018220579A1 (en) 2017-05-31 2018-12-06 Tropic Biosciences UK Limited Compositions and methods for increasing extractability of solids from coffee beans
WO2018220582A1 (en) 2017-05-31 2018-12-06 Tropic Biosciences UK Limited Methods of selecting cells comprising genome editing events
WO2018229764A1 (en) 2017-06-13 2018-12-20 Yeda Research And Development Co. Ltd. Treatment of advanced or progressive multiple sclerosis
WO2019012542A1 (en) 2017-07-13 2019-01-17 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Detecting tissue-specific dna
WO2019012544A1 (en) 2017-07-13 2019-01-17 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Dual-probe digital droplet pcr strategy for specific detection of tissue-specific circulating dna molecules
WO2019012543A1 (en) 2017-07-13 2019-01-17 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Dna targets as tissue-specific methylation markers
WO2019021284A1 (en) 2017-07-24 2019-01-31 Yeda Research And Development Co. Ltd. Combination therapy for the treatment of cancer
WO2019035128A1 (en) 2017-08-14 2019-02-21 Yeda Research And Development Co. Ltd. Immunotherapy against transferrin receptor 1 (tfr1)-tropic arenaviruses
WO2019038771A1 (en) 2017-08-23 2019-02-28 Technion Research & Development Foundation Limited Compositions and methods for improving alcohol tolerance in yeast
US11555199B2 (en) 2017-09-19 2023-01-17 Tropic Biosciences UK Limited Modifying the specificity of plant non-coding RNA molecules for silencing gene expression
EP4170029A2 (en) 2017-09-19 2023-04-26 Tropic Biosciences UK Limited Modifying the specifity of plant non-coding rna molecules for silencing gene expression
WO2019094595A2 (en) 2017-11-09 2019-05-16 Pinteon Therapeutics Inc. Methods and compositions for the generation and use of humanized conformation-specific phosphorylated tau antibodies
WO2019097514A1 (en) 2017-11-14 2019-05-23 Yeda Research And Development Co. Ltd. Hematopoietic stem cells with improved properties
WO2019106671A1 (en) 2017-11-29 2019-06-06 Ramot At Tel-Aviv University Ltd. Methods of preventing or treating neurogenic shock
WO2019106667A1 (en) 2017-11-29 2019-06-06 Weedout Ltd. Compositions, kits and methods for controlling weed of the amaranthus genus
WO2019106680A1 (en) 2017-12-03 2019-06-06 Yeda Research And Development Co. Ltd. Treatment of an ischemic heart disease
WO2019116376A1 (en) 2017-12-17 2019-06-20 Yeda Research And Development Co. Ltd. Cop9 signalosome (csn) complex modulators and uses thereof
WO2019130313A1 (en) 2017-12-28 2019-07-04 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Method to reproduce circadian rhythms on a microfluidic chip
WO2019145964A1 (en) 2018-01-29 2019-08-01 Yeda Research And Development Co. Ltd. Combination of a mek inhibitor and a cdk4/6 inhibitor for the treatment of sarcoma
WO2019150373A1 (en) 2018-01-31 2019-08-08 Yeda Research And Development Co. Ltd. Endoplasmic reticulum targeting signal
WO2019155465A1 (en) 2018-02-08 2019-08-15 Yeda Research And Development Co. Ltd. Methods of identifying and using agents for treating diseases associated with intestinal barrier dysfunction
WO2019155459A1 (en) 2018-02-08 2019-08-15 Yeda Research And Development Co. Ltd. Inhibitors of the 20s proteasome
US11571433B2 (en) 2018-02-23 2023-02-07 Carmel Haifa University Economic Corporation Ltd. Methods for treating memory impairment and cognitive dysfunction
WO2019167047A1 (en) 2018-02-28 2019-09-06 The Medical Research, Infrastructure and Health Services Fund of the Tel Aviv Medical Center Methods of diagnosing and treating bladder cancer
WO2019175869A1 (en) 2018-03-12 2019-09-19 Yeda Research And Development Co. Ltd Treatment of a heart disease
WO2019186569A1 (en) 2018-03-29 2019-10-03 Yeda Research And Development Co. Ltd. Use of electric field gradients to control gene expression
WO2019186570A1 (en) 2018-03-29 2019-10-03 Yeda Research And Development Co. Ltd. Methods of disrupting a biofilm and/or preventing formation of same
US11648260B2 (en) 2018-03-29 2023-05-16 Technion Research And Development Foundation Limitted Vesicles comprising a PTEN inhibitor and uses of same
WO2019211750A1 (en) 2018-05-01 2019-11-07 Tropic Biosciences UK Limited Compositions and methods for reducing caffeine content in coffee beans
WO2019220437A1 (en) 2018-05-15 2019-11-21 Yeda Research And Development Co. Ltd. Vaccination with cancer neoantigens
WO2019220441A1 (en) 2018-05-15 2019-11-21 Hadasit Medical Research Services And Development Ltd. Compositions and methods for treating cancer resistant to an anti-cancer agent
WO2019229745A1 (en) 2018-05-27 2019-12-05 Biolinerx Ltd. Agi-134 combined with a checkpoint inhibitor for the treatment of solid tumors
WO2019234750A1 (en) 2018-06-07 2019-12-12 The State Of Israel, Ministry Of Agriculture & Rural Development, Agricultural Research Organization (Aro) (Volcani Center) Methods of regenerating and transforming cannabis
WO2019234754A1 (en) 2018-06-07 2019-12-12 The State Of Israel, Ministry Of Agriculture & Rural Development, Agricultural Research Organization (Aro) (Volcani Center) Nucleic acid constructs and methods of using same
WO2020003311A1 (en) 2018-06-25 2020-01-02 Yeda Research And Development Co. Ltd. Systems and methods for increasing efficiency of genome editing
WO2020008412A1 (en) 2018-07-04 2020-01-09 Ukko Inc. Methods of de-epitoping wheat proteins and use of same for the treatment of celiac disease
WO2020012467A2 (en) 2018-07-08 2020-01-16 Yeda Research And Development Co. Ltd. Person-specific assessment of probiotics responsiveness
WO2020012486A1 (en) 2018-07-11 2020-01-16 Kahr Medical Ltd. SIRPalpha-4-1BBL VARIANT FUSION PROTEIN AND METHODS OF USE THEREOF
WO2020012478A2 (en) 2018-07-11 2020-01-16 Immunity Pharma Ltd. Peptide compounds and therapeutic uses of same
WO2020026241A1 (en) 2018-07-31 2020-02-06 Collplant Ltd. Tobacco transgenic event and methods for detection and use thereof
WO2020035863A1 (en) 2018-08-14 2020-02-20 Yeda Research And Development Co. Ltd. Chimeric quiescin sulfhydryl oxidase (qsox1) antibodies and uses of same
WO2020039440A1 (en) 2018-08-24 2020-02-27 Yeda Research And Development Co. Ltd. Methods of modulating m2 macrophage polarization and use of same in therapy
WO2020058979A2 (en) 2018-09-20 2020-03-26 Yeda Research And Development Co. Ltd. Methods of treating amyotrophic lateral sclerosis
WO2020065647A1 (en) 2018-09-25 2020-04-02 Biolinerx Ltd. Methods of selecting treatment for cxcr4-associated cancer
WO2020089892A1 (en) 2018-10-28 2020-05-07 Yeda Research And Development Co. Ltd. Prevention of age related clonal hematopoiesis and diseases associated therewith
WO2020105050A2 (en) 2018-11-21 2020-05-28 Yeda Research And Development Co. Ltd. Method of treating cancer and compositions for same
WO2020152686A1 (en) 2019-01-23 2020-07-30 Yeda Research And Development Co. Ltd. Culture media for pluripotent stem cells
WO2020161724A1 (en) 2019-02-10 2020-08-13 Yeda Research And Development Co. Ltd. Anti-matrix metalloproteinase 7 (mmp-7) inhibitory antibody and uses thereof
WO2020165907A1 (en) 2019-02-14 2020-08-20 Yeda Research And Development Co. Ltd. Spt5 inhibitors and uses thereof
WO2020170239A1 (en) 2019-02-21 2020-08-27 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Methods of generating organoids for high throughput screening of drugs
WO2020170240A1 (en) 2019-02-21 2020-08-27 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Method for reduction drug-induced nephrotoxicity
WO2020178822A1 (en) 2019-03-05 2020-09-10 The State Of Israel, Ministry Of Agriculture & Rural Development, Agricultural Research Organization (Aro) (Volcani Center) Genome-edited birds
WO2020183419A1 (en) 2019-03-14 2020-09-17 Tropic Biosciences UK Limited Introducing silencing activity to dysfunctional rna molecules and modifying their specificity against a gene of interest
WO2020183414A2 (en) 2019-03-14 2020-09-17 Tropic Biosciences UK Limited Modifying the specificity of non-coding rna molecules for silencing genes in eukaryotic cells
WO2020183416A1 (en) 2019-03-14 2020-09-17 Tropic Biosciences UK Limited PRODUCTION OF dsRNA IN PLANT CELLS FOR PEST PROTECTION VIA GENE SILENCING
WO2020188572A1 (en) 2019-03-19 2020-09-24 Yeda Research And Development Co. Ltd. Bistable type ii opsins and uses thereof
WO2020194317A1 (en) 2019-03-28 2020-10-01 Yeda Research And Development Co. Ltd. Method of treating lipid-related disorders
WO2020202142A2 (en) 2019-03-31 2020-10-08 Yeda Research And Development Co. Ltd. Anti-viral and anti-tumoral compounds
WO2020222241A1 (en) 2019-05-02 2020-11-05 Yeda Research And Development Co. Ltd. Compositions comprising the propeptide of lysyl oxidase and uses thereof
WO2020230133A1 (en) 2019-05-13 2020-11-19 Yeda Research And Development Co. Ltd. Cell-free mirna biomarkers for prognosis and diagnosis of neurodegenerative diseases
WO2020234875A2 (en) 2019-05-19 2020-11-26 Yeda Research And Development Co. Ltd. Identification of recurrent mutated neopeptides
WO2020234888A1 (en) 2019-05-22 2020-11-26 Hadasit Medical Research Services And Development Ltd. Methods of culturing human pluripotent cells
WO2020237491A1 (en) 2019-05-28 2020-12-03 Shanghaitech University Composition and methods to treat ectodermal dysplasia 2, clouston type
WO2020250232A1 (en) 2019-06-12 2020-12-17 Hadasit Medical Research Services And Development Ltd. Methods of generating oligodendrocytes
WO2020255124A1 (en) 2019-06-16 2020-12-24 Yeda Research And Development Co. Ltd. Method for stabilizing intracellular rna
WO2020261281A1 (en) 2019-06-27 2020-12-30 Ramot At Tel-Aviv University Ltd. Semaphorin 3a antibodies and uses thereof
WO2021001784A1 (en) 2019-07-04 2021-01-07 Ukko Inc. De-epitoped alpha gliadin and use of same for the management of celiac disease and gluten sensitivity
WO2021005599A1 (en) 2019-07-11 2021-01-14 Kahr Medical Ltd. Heterodimers and methods of use thereof
WO2021009763A1 (en) 2019-07-16 2021-01-21 Yeda Research And Development Co. Ltd. Methods of treating pain
WO2021009740A1 (en) 2019-07-16 2021-01-21 Ramot At Tel-Aviv University Ltd. Compositions and methods for the treatment of tuberculosis
WO2021019526A1 (en) 2019-07-29 2021-02-04 Yeda Research And Development Co. Ltd. Methods of treating and diagnosing lung cancer
WO2021019536A1 (en) 2019-07-30 2021-02-04 The State Of Israel, Ministry Of Agriculture & Rural Development, Agricultural Research Organization (Aro) (Volcani Center) Methods of controlling cannabinoid synthesis in plants or cells and plants and cells produced thereby
WO2021028909A1 (en) 2019-08-12 2021-02-18 Yeda Research And Development Co. Ltd. Dna repair blood test for predicting response of lung cancer patients to immunotherapy
WO2021033176A1 (en) 2019-08-22 2021-02-25 Ariel Scientific Innovations Ltd. Scaled-up methods for purifying antibodies
WO2021038569A1 (en) 2019-08-27 2021-03-04 Yeda Research And Development Co. Ltd. Treatment of bacterial vaginosis
WO2021048852A1 (en) 2019-09-11 2021-03-18 Yeda Research And Development Co. Ltd. Methods of treating breast cancer
WO2021059269A1 (en) 2019-09-25 2021-04-01 Yeda Research And Development Co. Ltd. Assembly of protein complexes on a chip
WO2021084540A1 (en) 2019-10-30 2021-05-06 Yeda Research And Development Co. Ltd. Inhibitors of mmej pathway for prevention and treatment of pre-myeloid and myeloid malignancies
WO2021084526A1 (en) 2019-10-31 2021-05-06 Yeda Research And Development Co. Ltd. Engineered autotrophic bacteria for co2 conversion to organic materials
WO2021095031A2 (en) 2019-11-11 2021-05-20 Ibi-Ag Innovative Bio Insecticides Ltd. Insect control nanobodies and uses thereof
WO2021100034A1 (en) 2019-11-19 2021-05-27 Protalix Ltd. Removal of constructs from transformed cells
WO2021100041A1 (en) 2019-11-20 2021-05-27 Yeda Research And Development Co. Ltd. Treating alzheimer's disease
WO2021130753A1 (en) 2019-12-22 2021-07-01 Yeda Research And Development Co. Ltd. Diagnosis of frontotemporal dementia
WO2021130752A1 (en) 2019-12-22 2021-07-01 Yeda Research And Development Co. Ltd. Systems and methods for identifying cells that have undergone genome editing
WO2021137222A1 (en) 2019-12-31 2021-07-08 Ichilov Tech Ltd. Methods of treating atopic dermatitis
WO2021137231A1 (en) 2019-12-31 2021-07-08 Kahr Medical Ltd. Methods of culturing t cells with a 4-1bbl fusion polypeptide and uses of same
WO2021137230A1 (en) 2019-12-31 2021-07-08 Kahr Medical Ltd. Methods of culturing t cells and uses of same
WO2021144798A1 (en) 2020-01-15 2021-07-22 Immunity Pharma Ltd. Peptide compounds and methods of treating diseases using same
WO2021149053A1 (en) 2020-01-22 2021-07-29 Yeda Research And Development Co. Ltd. Multispecific antibodies for use in treating diseases
WO2021152584A1 (en) 2020-01-28 2021-08-05 Ariel Scientific Innovations Ltd. Methods of analyzing cell membranes
WO2021152587A1 (en) 2020-01-30 2021-08-05 Yeda Research And Development Co. Ltd. Treating acute liver disease with tlr-mik inhibitors
WO2021152592A1 (en) 2020-01-30 2021-08-05 Yeda Research And Development Co. Ltd. Methods of treating cancer
WO2021152590A1 (en) 2020-01-30 2021-08-05 Yeda Research And Development Co. Ltd. Articles of manufacture comprising anti pd-l1 antibodies and their use in therapy
WO2021152586A1 (en) 2020-01-30 2021-08-05 Yeda Research And Development Co. Ltd. Methods of analyzing microbiome, immunoglobulin profile and physiological state
WO2021156878A2 (en) 2020-02-09 2021-08-12 Nlc Pharma Ltd Rapid detection test for sars-cov-2
WO2021161310A1 (en) 2020-02-10 2021-08-19 Yeda Research And Development Co. Ltd. Method for analyzing cell clusters
WO2021173674A1 (en) 2020-02-26 2021-09-02 A2 Biotherapeutics, Inc. Polypeptides targeting mage-a3 peptide-mhc complexes and methods of use thereof
WO2021186431A1 (en) 2020-03-16 2021-09-23 Yeda Research And Development Co. Ltd. Peptide analogs and use of same in treating diseases, disorders or conditions associated with a mutant p53 protein
WO2021199039A1 (en) 2020-03-29 2021-10-07 Yeda Research And Development Co. Ltd. Variants of beta-glucocerebrosidase for use in treating gaucher disease
WO2021199047A1 (en) 2020-03-31 2021-10-07 Biomuse Ltd. Bacteria for the prevention and treatment of smoke-induced lung damage
WO2021205444A1 (en) 2020-04-06 2021-10-14 Yeda Research And Development Co. Ltd. Methods of diagnosing cancer and predicting responsiveness to therapy
WO2021205459A1 (en) 2020-04-07 2021-10-14 Ramot At Tel-Aviv University Ltd. Cannabidiol-containing compositions and uses thereof
WO2021209995A1 (en) 2020-04-13 2021-10-21 Exoprother Medical Ltd. Cell-derived vesicles comprising wild-type p53 protein for antiviral therapy
EP3895697A1 (en) 2020-04-16 2021-10-20 Ichilov Tech Ltd. Cell-derived particles presenting heterologous cd24 and use thereof in therapy
WO2021210002A1 (en) 2020-04-16 2021-10-21 Ichilov Tech Ltd. Cell-derived particles presenting heterologous cd24 and use thereof in therapy
WO2021229577A1 (en) 2020-05-12 2021-11-18 Collplant Ltd. Collagen as a delivery tool for metal-based anti-viral agents
WO2021234698A1 (en) 2020-05-20 2021-11-25 Yeda Research And Development Co. Ltd. Indexing spatial information for a single-cell downstream applications
WO2021260675A1 (en) 2020-06-24 2021-12-30 Yeda Research And Development Co. Ltd. Agents for sensitizing solid tumors to treatment
WO2022034575A1 (en) 2020-08-09 2022-02-17 Yeda Research And Development Co. Ltd. Mage-a1 specific t cell receptor and uses thereof
WO2022034588A1 (en) 2020-08-10 2022-02-17 Yeda Research And Development Co. Ltd. Compositions for diagnosis and treatment of coronavirus infections
WO2022038536A1 (en) 2020-08-18 2022-02-24 International Rice Research Institute Methods of increasing outcrossing rates in gramineae
WO2022059015A1 (en) 2020-09-21 2022-03-24 Yeda Research And Development Co. Ltd. Method for modulating weight
WO2022064494A2 (en) 2020-09-23 2022-03-31 Yeda Research And Development Co. Ltd. Methods and compositions for treating coronaviral infections
WO2022070194A1 (en) 2020-10-01 2022-04-07 Yeda Research And Development Co. Ltd. Method of diagnosing breast cancer
WO2022074646A1 (en) 2020-10-05 2022-04-14 Protalix Ltd. Dicer-like knock-out plant cells
WO2022074656A1 (en) 2020-10-07 2022-04-14 Protalix Ltd. Long-acting dnase
WO2022079719A1 (en) 2020-10-15 2022-04-21 Yeda Research And Development Co. Ltd. Method of treating myeloid malignancies
WO2022091100A1 (en) 2020-10-29 2022-05-05 Yeda Research And Development Co. Ltd. Polynucleotides for rna editing and methods of using same
WO2022097157A2 (en) 2020-11-09 2022-05-12 1E Therapeutics, Ltd. Catalytic sequence based methods of treating or preventing bacterial infections
WO2022115498A1 (en) 2020-11-26 2022-06-02 Ukko Inc. Modified high molecular weight glutenin subunit and uses thereof
WO2022130384A1 (en) 2020-12-17 2022-06-23 Yeda Research And Development Co. Ltd. Controlling ubiquitination of mlkl for treatment of disease
US11879140B2 (en) 2020-12-28 2024-01-23 1E Therapeutics Ltd. P21 mRNA targeting DNAzymes
WO2022144882A2 (en) 2020-12-28 2022-07-07 1E Therapeutics, Ltd. P21 mrna target areas for silencing
WO2022144883A2 (en) 2020-12-28 2022-07-07 1E Therapeutics, Ltd. P21 mrna targeting dnazymes
WO2022149142A2 (en) 2021-01-10 2022-07-14 Supermeat The Essence Of Meat Ltd. Pluripotent stem cell aggregates and microtissues obtained therefrom for the cultured meat industry
WO2022153286A1 (en) 2021-01-14 2022-07-21 Yeda Research And Development Co. Ltd. Methods of producing vitamin d
WO2022157774A1 (en) 2021-01-21 2022-07-28 Yeda Research And Development Co. Ltd. Antibodies, peptides and combinations of same for the treatment or prevention of coronavirus infection
WO2022175952A1 (en) 2021-02-18 2022-08-25 Yeda Research And Development Co. Ltd. Method of generating vaccines
WO2022175951A1 (en) 2021-02-18 2022-08-25 Yeda Research And Development Co. Ltd. Genetically modified bacteria for generating vaccines
WO2022195589A2 (en) 2021-03-16 2022-09-22 Yeda Research And Development Co. Ltd. Methods and devices for ex-utero mouse embryonic development
WO2022208369A1 (en) 2021-03-30 2022-10-06 Biomx Ltd. Pseudomonas bacteriophage and uses thereof
WO2022215080A1 (en) 2021-04-08 2022-10-13 Yeda Research And Development Co. Ltd. A combined use of ketamine and retigabine (ezogabine) for the treatment of psychiatric disorders
WO2022238947A1 (en) 2021-05-12 2022-11-17 Biomx Ltd. Staphylococcus bacteriophage and uses thereof
WO2022254430A1 (en) 2021-05-30 2022-12-08 Yeda Research And Development Co. Ltd. Anti-microbial peptide (amp) signatures for diagnostics, stratification, and treatment of microbiome-associated disease
WO2022259242A1 (en) 2021-06-06 2022-12-15 Yeda Research And Development Co. Ltd. Combined treatment for cancer
WO2022264132A1 (en) 2021-06-13 2022-12-22 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Method for reprogramming human cells
NL2028466B1 (en) 2021-06-16 2022-12-21 Sakata Holland B V Methods of sorting matthiola seeds
WO2022264076A1 (en) 2021-06-16 2022-12-22 Seedx Technologies Inc. Methods of sorting matthiola seeds
WO2023275255A1 (en) 2021-07-02 2023-01-05 Tropic Biosciences UK Limited Delay or prevention of browning in banana fruit
WO2023003809A1 (en) 2021-07-18 2023-01-26 Gamida-Cell Ltd. Therapeutic nk cell populations
WO2023002492A1 (en) 2021-07-22 2023-01-26 Yeda Research And Development Co. Ltd. Codon optimization of nucleic acids
EP4130028A1 (en) 2021-08-03 2023-02-08 Rhazes Therapeutics Ltd Engineered tcr complex and methods of using same
WO2023012584A2 (en) 2021-08-03 2023-02-09 Genicity Limited Engineered tcr complex and methods of using same
WO2023018621A1 (en) 2021-08-10 2023-02-16 Gamida-Cell Ltd. Engineered nk cells, methods of their production and uses thereof
GB202112865D0 (en) 2021-09-09 2021-10-27 Tropic Biosciences Uk Ltd Resistance to black sigatoka disease in banana
GB202112866D0 (en) 2021-09-09 2021-10-27 Tropic Biosciences Uk Ltd Resistance to fusarium wilt in a banana
WO2023042202A1 (en) 2021-09-14 2023-03-23 Yeda Research And Development Co. Ltd. Multispecific antibodies for use in treating diseases
WO2023105526A1 (en) 2021-12-08 2023-06-15 Yeda Research And Development Co. Ltd. Multipotent lung progenitor cells for lung regeneration
WO2023209708A1 (en) 2022-04-25 2023-11-02 Yeda Research And Development Co. Ltd. Compositions for altering cyclic adp-ribose secondary messenger signalling

Also Published As

Publication number Publication date
AT320145B (en) 1975-01-27
SE398557B (en) 1977-12-27
IL38371A0 (en) 1972-02-29
FI54034C (en) 1978-09-11
DE2164768B2 (en) 1976-01-22
JPS58117455A (en) 1983-07-13
JPS5834783B1 (en) 1983-07-28
NL154599B (en) 1977-09-15
GB1348938A (en) 1974-03-27
BR7108553D0 (en) 1973-07-03
CA964560A (en) 1975-03-18
JPS58117456A (en) 1983-07-13
AU3698671A (en) 1973-06-21
EG11604A (en) 1977-08-15
FI54034B (en) 1978-05-31
DE2164768A1 (en) 1972-07-20
FR2120835A5 (en) 1972-08-18
CH557030A (en) 1974-12-13
IL38371A (en) 1974-06-30
DK150690C (en) 1988-06-06
BE777309A (en) 1972-04-17
ZA718332B (en) 1972-09-27
DK150690B (en) 1987-05-25
IT965020B (en) 1974-01-31
ES398372A1 (en) 1975-06-16
NL7018838A (en) 1972-06-30
AU467394B2 (en) 1975-11-27

Similar Documents

Publication Publication Date Title
US3839153A (en) Process for the detection and determination of specific binding proteins and their corresponding bindable substances
US3791932A (en) Process for the demonstration and determination of reaction components having specific binding affinity for each other
US3850752A (en) Process for the demonstration and determination of low molecular compounds and of proteins capable of binding these compounds specifically
USRE31006E (en) Process for the demonstration and determination of reaction components having specific binding affinity for each other
USRE29169E (en) Process for the demonstration and determination of reaction components having specific binding affinity for each other
US4828985A (en) Antibodies against the complex of a small molecule and its binding protein, their preparation and their use in diagnostic methods
US4434236A (en) Immunoassay wherein labeled antibody is displaced from immobilized analyte-analogue
US4343896A (en) Method and test pack for the demonstration and determination of an antigen or antibody
US4243749A (en) Immunoassay employing an enzyme label
EP0177531B1 (en) Antibodies, manufacture and use
US4427781A (en) Particle agglutination immunoassay with agglutinator for determining haptens; PACIA
EP0140489A1 (en) Method for stabilizing immunologically active substances immobilized on an insoluble carrier and their use in the preparation of reagents for measuring physiologically active substances
JPS60259964A (en) Assay of immunologically active substance in analysis sample
EP0383313A2 (en) Reagent for immunoassay, and kit containing the same
EP0119767B1 (en) Method of measuring ligands
Jones et al. Double-antibody ELISA for detection of trace amounts of pig meat in raw meat mixtures
EP0124366B1 (en) Method of measuring biological ligands
EP0028132A2 (en) Method of passively adsorbing immuno-reactive haptens to solid phases
Schwarz et al. Epitope-selective, monoclonal-antibody-based immunoradiometric assays of predictable specificity for differential measurement of choriogonadotropin and its subunits.
JPH0616044B2 (en) Immunological latex agglutination method
US5382530A (en) Method for the quantitative determination of a free form of substances present in biological fluids
Scherrmann et al. Specific interaction between antidigoxin antibodies and digoxin-like immunoreactive substances in cord serum.
US4713350A (en) Hydrophilic assay reagent containing one member of specific binding pair
EP0028133A2 (en) Method of detecting and quantitating haptens and antigens
EP0100395B1 (en) Reagent for determination of human urine kallikrein